Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938961917> ?p ?o ?g. }
- W2938961917 endingPage "22" @default.
- W2938961917 startingPage "14" @default.
- W2938961917 abstract "Mechanism of PAH mixtures, using granulosa tumour cells, was investigated. Cells were exposed to a mixture of all 16 priority PAHs (M1) or a mixture of five PAHs not classified as human carcinogens (M2). The effect of siAHR, siAHRR and siNFKB2 on the expression of CYP1A1, CYP1B1, GSTM1, ERα, AR and cell proliferation was described. M1 decreased AhR and CYP1A1, while increased AhRR and ARNT expression. M2 also decreased AhR and CYP1A1 but had no effect on AhRR expression. siAHRR reversed the inhibitory effect of M1 on AhR and CYP1A1,while inhibitory effect of M2 was still observed. siNFKB2 reversed inhibitory effect of both mixtures on AhR and CYP1A1 expression and stimulatory effect of M1 on AhRR expression. siAHR reversed stimulatory effect of both mixtures on ERα expression. Stimulatory effect of M1 on cell proliferation was not observed in siAHR, was still observed in siESR1 cells. M2 had no effect on cell proliferation, however stimulatory effect was appeared in siAHR and siESR1cells. In conclusion: M1 by activation of AhRR and NFkB p52, but M2 only by activation of NFκB attenuated AhR signalling and ligand-induced CYP1A1 expression. Interaction between AhR and ER following M1 and M2 exposure is primarily initiated through AhR." @default.
- W2938961917 created "2019-04-25" @default.
- W2938961917 creator A5002064694 @default.
- W2938961917 creator A5005820758 @default.
- W2938961917 creator A5056988673 @default.
- W2938961917 creator A5084306838 @default.
- W2938961917 date "2019-08-01" @default.
- W2938961917 modified "2023-10-17" @default.
- W2938961917 title "Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells" @default.
- W2938961917 cites W1597660082 @default.
- W2938961917 cites W1964109666 @default.
- W2938961917 cites W1980296148 @default.
- W2938961917 cites W1982706435 @default.
- W2938961917 cites W1986321253 @default.
- W2938961917 cites W1989986502 @default.
- W2938961917 cites W1995420714 @default.
- W2938961917 cites W1996162026 @default.
- W2938961917 cites W1996909912 @default.
- W2938961917 cites W2007225446 @default.
- W2938961917 cites W2018951556 @default.
- W2938961917 cites W2030005694 @default.
- W2938961917 cites W2030678473 @default.
- W2938961917 cites W2032217767 @default.
- W2938961917 cites W2045931107 @default.
- W2938961917 cites W2051729077 @default.
- W2938961917 cites W2055084808 @default.
- W2938961917 cites W2059629519 @default.
- W2938961917 cites W2059702269 @default.
- W2938961917 cites W2062318487 @default.
- W2938961917 cites W2066254714 @default.
- W2938961917 cites W2073563548 @default.
- W2938961917 cites W2082809617 @default.
- W2938961917 cites W2085397935 @default.
- W2938961917 cites W2087250942 @default.
- W2938961917 cites W2089069133 @default.
- W2938961917 cites W2097893055 @default.
- W2938961917 cites W2105900029 @default.
- W2938961917 cites W2111893476 @default.
- W2938961917 cites W2112131993 @default.
- W2938961917 cites W2118744236 @default.
- W2938961917 cites W2120473115 @default.
- W2938961917 cites W2123617510 @default.
- W2938961917 cites W2124739658 @default.
- W2938961917 cites W2129026083 @default.
- W2938961917 cites W2132492539 @default.
- W2938961917 cites W2132522883 @default.
- W2938961917 cites W2136536032 @default.
- W2938961917 cites W2137999397 @default.
- W2938961917 cites W2138165502 @default.
- W2938961917 cites W2138913971 @default.
- W2938961917 cites W2144062280 @default.
- W2938961917 cites W2153484289 @default.
- W2938961917 cites W2157811049 @default.
- W2938961917 cites W2159334494 @default.
- W2938961917 cites W2315613727 @default.
- W2938961917 cites W2328386272 @default.
- W2938961917 cites W2508345476 @default.
- W2938961917 cites W2592076970 @default.
- W2938961917 cites W2736074206 @default.
- W2938961917 doi "https://doi.org/10.1016/j.toxlet.2019.04.008" @default.
- W2938961917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30980910" @default.
- W2938961917 hasPublicationYear "2019" @default.
- W2938961917 type Work @default.
- W2938961917 sameAs 2938961917 @default.
- W2938961917 citedByCount "6" @default.
- W2938961917 countsByYear W29389619172020 @default.
- W2938961917 countsByYear W29389619172021 @default.
- W2938961917 countsByYear W29389619172022 @default.
- W2938961917 crossrefType "journal-article" @default.
- W2938961917 hasAuthorship W2938961917A5002064694 @default.
- W2938961917 hasAuthorship W2938961917A5005820758 @default.
- W2938961917 hasAuthorship W2938961917A5056988673 @default.
- W2938961917 hasAuthorship W2938961917A5084306838 @default.
- W2938961917 hasConcept C104317684 @default.
- W2938961917 hasConcept C114246631 @default.
- W2938961917 hasConcept C134018914 @default.
- W2938961917 hasConcept C155701950 @default.
- W2938961917 hasConcept C17077164 @default.
- W2938961917 hasConcept C185592680 @default.
- W2938961917 hasConcept C190283241 @default.
- W2938961917 hasConcept C33594762 @default.
- W2938961917 hasConcept C45815257 @default.
- W2938961917 hasConcept C526171541 @default.
- W2938961917 hasConcept C55493867 @default.
- W2938961917 hasConcept C62112901 @default.
- W2938961917 hasConcept C62231903 @default.
- W2938961917 hasConcept C62478195 @default.
- W2938961917 hasConcept C86339819 @default.
- W2938961917 hasConcept C86803240 @default.
- W2938961917 hasConcept C95444343 @default.
- W2938961917 hasConceptScore W2938961917C104317684 @default.
- W2938961917 hasConceptScore W2938961917C114246631 @default.
- W2938961917 hasConceptScore W2938961917C134018914 @default.
- W2938961917 hasConceptScore W2938961917C155701950 @default.
- W2938961917 hasConceptScore W2938961917C17077164 @default.
- W2938961917 hasConceptScore W2938961917C185592680 @default.
- W2938961917 hasConceptScore W2938961917C190283241 @default.
- W2938961917 hasConceptScore W2938961917C33594762 @default.