FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938971239> ?p ?o ?g. }

• W2938971239 endingPage "856" @default.
• W2938971239 startingPage "852" @default.
• W2938971239 abstract "Glucose limitation activates p53, which functions as an adaptive response to maintain cell survival. However, p53 is frequently deleted or mutated in a variety of tumors, while most cancer cells can acclimatize themselves to metabolically unfavorable surrounding, indicating that alternative mechanisms other than p53 transactivation underly adaptive response of cancer cells with p53 deletion or mutation to metabolically hostile environment. Sestrin 2 (SESN2) is a p53 downstream target, which plays a protective role against various stressful stimuli, such as genotoxic, energetic, and oxidative stress. In the current study, we demonstrated that SESN2 transcript was stabilized by glucose limitation at the posttranscriptional level irrespective of p53 status. Importantly, SESN2 also protected cells from metabolic stress triggered by glucose limitation in a p53-independent manner. Our data indicated that stabilization of SESN2 transcript might be an alternative adaptive response to metabolic stress other than p53 activation. Thereby, the current study highlights the significance of stabilization of SESN2 transcript in adaptation of cells with p53 deletion or mutation to metabolic stress." @default.
• W2938971239 created "2019-04-25" @default.
• W2938971239 creator A5001373585 @default.
• W2938971239 creator A5001568413 @default.
• W2938971239 creator A5003753200 @default.
• W2938971239 creator A5016853386 @default.
• W2938971239 creator A5021278890 @default.
• W2938971239 creator A5061112023 @default.
• W2938971239 creator A5069094261 @default.
• W2938971239 creator A5087812098 @default.
• W2938971239 date "2019-06-01" @default.
• W2938971239 modified "2023-10-16" @default.
• W2938971239 title "Sestrin 2 protects against metabolic stress in a p53-independent manner" @default.
• W2938971239 cites W1232556488 @default.
• W2938971239 cites W1971155457 @default.
• W2938971239 cites W1972618720 @default.
• W2938971239 cites W1975701262 @default.
• W2938971239 cites W1981284402 @default.
• W2938971239 cites W1987586434 @default.
• W2938971239 cites W1991510903 @default.
• W2938971239 cites W2012015257 @default.
• W2938971239 cites W2014267867 @default.
• W2938971239 cites W2018720126 @default.
• W2938971239 cites W2019178802 @default.
• W2938971239 cites W2021129711 @default.
• W2938971239 cites W2022660428 @default.
• W2938971239 cites W2028897202 @default.
• W2938971239 cites W2046100445 @default.
• W2938971239 cites W2051233997 @default.
• W2938971239 cites W2057762456 @default.
• W2938971239 cites W2081920342 @default.
• W2938971239 cites W2098014021 @default.
• W2938971239 cites W2117275311 @default.
• W2938971239 cites W2485481679 @default.
• W2938971239 cites W2789488476 @default.
• W2938971239 doi "https://doi.org/10.1016/j.bbrc.2019.04.072" @default.
• W2938971239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31000199" @default.
• W2938971239 hasPublicationYear "2019" @default.
• W2938971239 type Work @default.
• W2938971239 sameAs 2938971239 @default.
• W2938971239 citedByCount "6" @default.
• W2938971239 countsByYear W29389712392020 @default.
• W2938971239 countsByYear W29389712392021 @default.
• W2938971239 countsByYear W29389712392022 @default.
• W2938971239 countsByYear W29389712392023 @default.
• W2938971239 crossrefType "journal-article" @default.
• W2938971239 hasAuthorship W2938971239A5001373585 @default.
• W2938971239 hasAuthorship W2938971239A5001568413 @default.
• W2938971239 hasAuthorship W2938971239A5003753200 @default.
• W2938971239 hasAuthorship W2938971239A5016853386 @default.
• W2938971239 hasAuthorship W2938971239A5021278890 @default.
• W2938971239 hasAuthorship W2938971239A5061112023 @default.
• W2938971239 hasAuthorship W2938971239A5069094261 @default.
• W2938971239 hasAuthorship W2938971239A5087812098 @default.
• W2938971239 hasConcept C104317684 @default.
• W2938971239 hasConcept C121608353 @default.
• W2938971239 hasConcept C1292079 @default.
• W2938971239 hasConcept C139807058 @default.
• W2938971239 hasConcept C143425029 @default.
• W2938971239 hasConcept C150194340 @default.
• W2938971239 hasConcept C169760540 @default.
• W2938971239 hasConcept C2776151105 @default.
• W2938971239 hasConcept C33507282 @default.
• W2938971239 hasConcept C501734568 @default.
• W2938971239 hasConcept C502942594 @default.
• W2938971239 hasConcept C54355233 @default.
• W2938971239 hasConcept C552990157 @default.
• W2938971239 hasConcept C55493867 @default.
• W2938971239 hasConcept C78604142 @default.
• W2938971239 hasConcept C86803240 @default.
• W2938971239 hasConcept C95444343 @default.
• W2938971239 hasConcept C96232424 @default.
• W2938971239 hasConceptScore W2938971239C104317684 @default.
• W2938971239 hasConceptScore W2938971239C121608353 @default.
• W2938971239 hasConceptScore W2938971239C1292079 @default.
• W2938971239 hasConceptScore W2938971239C139807058 @default.
• W2938971239 hasConceptScore W2938971239C143425029 @default.
• W2938971239 hasConceptScore W2938971239C150194340 @default.
• W2938971239 hasConceptScore W2938971239C169760540 @default.
• W2938971239 hasConceptScore W2938971239C2776151105 @default.
• W2938971239 hasConceptScore W2938971239C33507282 @default.
• W2938971239 hasConceptScore W2938971239C501734568 @default.
• W2938971239 hasConceptScore W2938971239C502942594 @default.
• W2938971239 hasConceptScore W2938971239C54355233 @default.
• W2938971239 hasConceptScore W2938971239C552990157 @default.
• W2938971239 hasConceptScore W2938971239C55493867 @default.
• W2938971239 hasConceptScore W2938971239C78604142 @default.
• W2938971239 hasConceptScore W2938971239C86803240 @default.
• W2938971239 hasConceptScore W2938971239C95444343 @default.
• W2938971239 hasConceptScore W2938971239C96232424 @default.
• W2938971239 hasFunder F4320321001 @default.
• W2938971239 hasIssue "4" @default.
• W2938971239 hasLocation W29389712391 @default.
• W2938971239 hasLocation W29389712392 @default.
• W2938971239 hasOpenAccess W2938971239 @default.
• W2938971239 hasPrimaryLocation W29389712391 @default.
• W2938971239 hasRelatedWork W2095001078 @default.
• W2938971239 hasRelatedWork W2148141835 @default.

• next