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- W2938991085 abstract "Objectives The decision to administer antenatal corticosteroids (ACS) to women who present with threatened preterm birth prior to 25 weeks remains controversial. Recent studies suggest an improvement in survival with administration of ACS prior to 24 weeks, with marginal improvement in morbidities. As such, our objectives were to evaluate the effect of ACS on survival in extreme prematurity, and on morbidities associated with preterm birth. Methods A retrospective chart review was conducted on patients who delivered after threatened preterm birth between gestational ages (GA) of 23-25 weeks at a large tertiary academic centre between Jan 1st 2003 and Dec 31st 2017. Multiple gestation pregnancies, terminations, and patients who declined neonatal resuscitation were excluded. Logistic regression was used to assess the effect of ACS treatment on neonatal mortality and morbidity, while controlling for maternal age, GA, and maternal complications. Results A total of 435 singleton births met criteria, with 422 mothers receiving at least one dose of ACS and 13 receiving no ACS. Neonatal mortality was significantly lower for infants exposed to at least one dose of ACS (OR=0.225, 95% CI=0.067-0.762). Administration of ACS did not show any significant effect on morbidity, but did show a reduction in intraventricular hemorrhage (OR=0.599, 95% CI=0.130–2.758) and necrotizing enterocolitis (OR=0.872, 95% CI=0.147–5.163), and increased odds of chronic lung disease (OR=1.272, 95% CI=0.347–4.661) and pneumothorax (OR=1.124, 95% CI=0.113–11.128). Conclusions Treatment with ACS for infants born at 23 to 25 weeks gestation was associated with a lower rate of neonatal mortality. No significant effect on morbidity was demonstrated." @default.
- W2938991085 created "2019-04-25" @default.
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- W2938991085 date "2019-05-01" @default.
- W2938991085 modified "2023-09-28" @default.
- W2938991085 title "THE EFFECT OF ANTENATAL CORTICOSTEROIDS ON SURVIVAL IN EXTREME PREMATURITY" @default.
- W2938991085 doi "https://doi.org/10.1016/j.jogc.2019.02.199" @default.
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