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- W2938994872 abstract "Introduction: Previous research focused mainly on individual nutrients or food items. In this study, we assessed the association between overall dietary patterns derived from a semi-quantitative food frequency questionnaire (FFQ) and bone and blood lead levels among middle-aged to elderly men in the VA Normative Aging Study. Methods: We used K-shell-X-ray fluorescence to measure tibia and patella bone lead levels, and graphite furnace atomic absorption spectroscopy to measure blood lead levels. The overall dietary pattern scores were derived from a 135-item FFQ by using factor analysis. Linear mixed effect models were utilized to for the prediction of blood lead levels among 983 subjects with a total 3669 observations from 1984 to 2008. We constructed linear models to determine the effects of dietary patterns on bone lead levels among 703 subjects for patella lead and 702 subjects for tibia lead. Results: Two major dietary patterns were identified: high ‘prudent’ pattern scores characterized by high intakes of fruit, legumes, vegetables, whole grains, poultry, and seafood; and high ‘Western’ pattern scores characterized by high intakes of processed meat, red meat, refined grains, high-fat dairy products, fries, butter, and eggs. After adjusting for age, smoking, education, area-level education and income, subjects in the highest tertile of prudent scores (vs. the lowest tertile) had a 0.51 μg/dL (95% CI: -0.92, -0.09) lower blood lead levels; 4.49 μg/g (95%CI: -7.66, -1.33) lower patella lead; and 2.37 μg/g (95%CI: -4.54, -0.19) lower tibia lead. After multivariate adjustment, men in the highest tertile (vs. the lowest) of Western scores had a 0.60 μg/dL (95% CI: 0.19, 1.02) higher for blood lead; 4.33 μg/g (95% CI: 1.16, 7.51) higher for patella lead; 3.32 μg/g (95% CI: 1.14, 5.51) higher for tibia lead. Conclusion: The findings suggest that lead body burdens are positively associated with Western diet, but inversely associated with prudent diet." @default.
- W2938994872 created "2019-04-25" @default.
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- W2938994872 date "2016-08-17" @default.
- W2938994872 modified "2023-10-16" @default.
- W2938994872 title "Relation of Dietary Patterns to Bone and Blood Lead Levels in the Normative Aging Study" @default.
- W2938994872 doi "https://doi.org/10.1289/isee.2016.4109" @default.
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