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- W2939125857 abstract "Chromen-4-one substituted oxadiazole analogs 1–19 have been synthesized, characterized and evaluated for β-glucuronidase inhibition. All analogs exhibited a variable degree of β-glucuronidase inhibitory activity with IC50 values ranging in between 0.8 ± 0.1–42.3 ± 0.8 μM when compared with the standard d-saccharic acid 1,4 lactone (IC50 = 48.1 ± 1.2 μM). Structure activity relationship has been established for all compounds. Molecular docking studies were performed to predict the binding interaction of the compounds with the active site of enzyme." @default.
- W2939125857 created "2019-04-25" @default.
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- W2939125857 date "2019-04-18" @default.
- W2939125857 modified "2023-09-26" @default.
- W2939125857 title "Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent β-Glucuronidase Inhibitors" @default.
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- W2939125857 doi "https://doi.org/10.3390/molecules24081528" @default.
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