Matches in SemOpenAlex for { <https://semopenalex.org/work/W2939169849> ?p ?o ?g. }
- W2939169849 endingPage "619" @default.
- W2939169849 startingPage "613" @default.
- W2939169849 abstract "Frailty is associated with functional decline and reduced ability to cope with physiological challenges. The pathophysiological changes in frailty include inflammation, endocrine disturbances, neuromuscular and immune dysfunction. However, comprehensive information on the relationship between biological markers and frailty is scarce. We aimed to determine the relationship between selected biomarkers and frailty among Malaysian older adults. In this cross sectional study, 600 community dwelling older adults were randomly selected from ten different areas in Klang Valley. A total of 382 participants met the inclusion criteria and consented to the study. Out of these, a subsamples of 91 participants were selected for biomarkers analysis. Frailty was defined using Fried’s criteria. Fasting blood glucose, lipid profile, albumin, selected frailty biomarkers including IL-6, TNF- alpha and IGF-1 and vitamin D together with free L-carnitine and acetyl L-carnitine were analysed. The results showed a significantly higher level of serum IL-6 and TNF-α among participants classified as frail as compared to pre-frail and robust (p<0.05). With respect to nutritional biomarkers, binary logistic regression showed that vitamin D deficiency is associated with three times higher risk of frailty (p<0.05). There was no significant relationship between blood L-carnitines and frailty. Further research is required to explore the relationship between L-carnitine and frailty using different parameters involved in L-carnitine homeostasis such as CPTII enzyme and OCTN2 mutation. In conclusion, frailty was associated with increased level of inflammatory markers and vitamin D deficiency. It is empirical to promote healthy lifestyle or disease management to reduce inflammation and increase vitamin D status as one of the frailty prevention action plan among older adults." @default.
- W2939169849 created "2019-04-25" @default.
- W2939169849 creator A5013365342 @default.
- W2939169849 creator A5014407311 @default.
- W2939169849 creator A5073610486 @default.
- W2939169849 creator A5087253380 @default.
- W2939169849 date "2019-03-31" @default.
- W2939169849 modified "2023-10-16" @default.
- W2939169849 title "Blood Inflammatory Markers, Anabolic Hormone, Vitamin D and L-Carnitine Status According to Frailty Status among Older Adults" @default.
- W2939169849 cites W1820460245 @default.
- W2939169849 cites W1964091382 @default.
- W2939169849 cites W1971629816 @default.
- W2939169849 cites W1980696432 @default.
- W2939169849 cites W1988354245 @default.
- W2939169849 cites W1990200872 @default.
- W2939169849 cites W1994086134 @default.
- W2939169849 cites W1995898214 @default.
- W2939169849 cites W1998049880 @default.
- W2939169849 cites W2000514017 @default.
- W2939169849 cites W2000702542 @default.
- W2939169849 cites W2002302995 @default.
- W2939169849 cites W2005458272 @default.
- W2939169849 cites W2005822229 @default.
- W2939169849 cites W2008155571 @default.
- W2939169849 cites W2008210901 @default.
- W2939169849 cites W2020217600 @default.
- W2939169849 cites W2020989348 @default.
- W2939169849 cites W2029690418 @default.
- W2939169849 cites W2037158718 @default.
- W2939169849 cites W2041007000 @default.
- W2939169849 cites W2046119060 @default.
- W2939169849 cites W2047546995 @default.
- W2939169849 cites W2048270339 @default.
- W2939169849 cites W2049509562 @default.
- W2939169849 cites W2064474827 @default.
- W2939169849 cites W2081844354 @default.
- W2939169849 cites W2084593052 @default.
- W2939169849 cites W2085221388 @default.
- W2939169849 cites W2089387667 @default.
- W2939169849 cites W2101338610 @default.
- W2939169849 cites W2106647095 @default.
- W2939169849 cites W2108688205 @default.
- W2939169849 cites W2118540989 @default.
- W2939169849 cites W2122311887 @default.
- W2939169849 cites W2122593814 @default.
- W2939169849 cites W2124300981 @default.
- W2939169849 cites W2124556123 @default.
- W2939169849 cites W2130644795 @default.
- W2939169849 cites W2139199691 @default.
- W2939169849 cites W2155577996 @default.
- W2939169849 cites W2156817458 @default.
- W2939169849 cites W2164059021 @default.
- W2939169849 cites W2165629577 @default.
- W2939169849 cites W2199384772 @default.
- W2939169849 cites W2249595199 @default.
- W2939169849 doi "https://doi.org/10.17576/jsm-2019-4803-14" @default.
- W2939169849 hasPublicationYear "2019" @default.
- W2939169849 type Work @default.
- W2939169849 sameAs 2939169849 @default.
- W2939169849 citedByCount "2" @default.
- W2939169849 countsByYear W29391698492020 @default.
- W2939169849 countsByYear W29391698492022 @default.
- W2939169849 crossrefType "journal-article" @default.
- W2939169849 hasAuthorship W2939169849A5013365342 @default.
- W2939169849 hasAuthorship W2939169849A5014407311 @default.
- W2939169849 hasAuthorship W2939169849A5073610486 @default.
- W2939169849 hasAuthorship W2939169849A5087253380 @default.
- W2939169849 hasBestOaLocation W29391698491 @default.
- W2939169849 hasConcept C1008401 @default.
- W2939169849 hasConcept C124490489 @default.
- W2939169849 hasConcept C126322002 @default.
- W2939169849 hasConcept C134018914 @default.
- W2939169849 hasConcept C2778435403 @default.
- W2939169849 hasConcept C42407357 @default.
- W2939169849 hasConcept C71315377 @default.
- W2939169849 hasConcept C71924100 @default.
- W2939169849 hasConcept C74909509 @default.
- W2939169849 hasConceptScore W2939169849C1008401 @default.
- W2939169849 hasConceptScore W2939169849C124490489 @default.
- W2939169849 hasConceptScore W2939169849C126322002 @default.
- W2939169849 hasConceptScore W2939169849C134018914 @default.
- W2939169849 hasConceptScore W2939169849C2778435403 @default.
- W2939169849 hasConceptScore W2939169849C42407357 @default.
- W2939169849 hasConceptScore W2939169849C71315377 @default.
- W2939169849 hasConceptScore W2939169849C71924100 @default.
- W2939169849 hasConceptScore W2939169849C74909509 @default.
- W2939169849 hasIssue "3" @default.
- W2939169849 hasLocation W29391698491 @default.
- W2939169849 hasLocation W29391698492 @default.
- W2939169849 hasOpenAccess W2939169849 @default.
- W2939169849 hasPrimaryLocation W29391698491 @default.
- W2939169849 hasRelatedWork W1968380023 @default.
- W2939169849 hasRelatedWork W1970861121 @default.
- W2939169849 hasRelatedWork W2067041912 @default.
- W2939169849 hasRelatedWork W2069420617 @default.
- W2939169849 hasRelatedWork W2073769638 @default.
- W2939169849 hasRelatedWork W2098693342 @default.
- W2939169849 hasRelatedWork W2124292257 @default.