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- W2939190589 abstract "Methicillin-resistant Staphylococcus aureus (MRSA) infections have become a serious threat to public health because traditional antibiotics are less efficient. Here, we developed a simple and efficient combination of Bi2Te3 nanoparticles (NPs) with β-lactam antibiotics cefotaxime (CTX), which presented significant synergistic antibacterial activity against MRSA. The minimal inhibitory concentration of CTX decreased from 256 to 32 μg/mL in the presence of 8 μg/mL Bi2Te3 NPs. The results of cell membrane potential and cellular K+ content measurements demonstrated that the destruction of membrane functions is a factor in the synergistic mechanism. Furthermore, the induction of cellular reactive oxygen species generation, inhibition of β-lactamases induced by CTX and direct damage to the cell structure constituted other factors of the synergistic mechanism. These observations suggest that reviving the efficacy of ineffective β-lactam antibiotic CTX by Bi2Te3 NPs may be a potentially effective therapeutic strategy to overcome refractory MRSA infections." @default.
- W2939190589 created "2019-04-25" @default.
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- W2939190589 date "2019-07-01" @default.
- W2939190589 modified "2023-10-15" @default.
- W2939190589 title "Synergistic antibacterial mechanism of Bi2Te3 nanoparticles combined with the ineffective β-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus" @default.
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- W2939190589 doi "https://doi.org/10.1016/j.jinorgbio.2019.04.001" @default.
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