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• W2939279096 startingPage "3014" @default.
• W2939279096 abstract "Abstract The transition from recreational drug use to compulsive drug‐seeking habits, the hallmark of addiction, has been shown to depend on a shift in the locus of control over behaviour from the ventral to the dorsolateral striatum. This process has hitherto been considered to depend on the aberrant engagement of dopamine‐dependent plasticity processes within neuronal networks. However, exposure to drugs of abuse also triggers cellular and molecular adaptations in astrocytes within the striatum which could potentially contribute to the intrastriatal transitions observed during the development of drug addiction. Pharmacological interventions aiming to restore the astrocytic mechanisms responsible for maintaining homeostatic glutamate concentrations in the nucleus accumbens, that are altered by chronic exposure to addictive drugs, abolish the propensity to relapse in both preclinical and, to a lesser extent, clinical studies. Exposure to drugs of abuse also alters the function of astrocytes in the dorsolateral striatum, wherein dopaminergic mechanisms control drug‐seeking habits, associated compulsivity and relapse. This suggests that drug‐induced alterations in the glutamatergic homeostasis maintained by astrocytes throughout the entire striatum may interact with dopaminergic mechanisms to promote aberrant plasticity processes that contribute to the maintenance of maladaptive drug‐seeking habits. Capitalising on growing evidence that astrocytes play a fundamental regulatory role in glutamate and dopamine transmission in the striatum, we present an innovative model of a quadripartite synaptic microenvironment within which astrocytes channel functional interactions between the dopaminergic and glutamatergic systems that may represent the primary striatal functional unit that undergoes drug‐induced adaptations eventually leading to addiction." @default.
• W2939279096 created "2019-04-25" @default.
• W2939279096 creator A5044645453 @default.
• W2939279096 creator A5063194083 @default.
• W2939279096 date "2019-05-14" @default.
• W2939279096 modified "2023-09-25" @default.
• W2939279096 title "Beyond drug‐induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine‐dependent intrastriatal functional shifts that underlie the development of drug addiction: A working hypothesis" @default.
• W2939279096 cites W1485485331 @default.
• W2939279096 cites W1535419310 @default.
• W2939279096 cites W1548862642 @default.
• W2939279096 cites W1592375995 @default.
• W2939279096 cites W1646393677 @default.
• W2939279096 cites W178829061 @default.
• W2939279096 cites W1797578063 @default.
• W2939279096 cites W1832520743 @default.
• W2939279096 cites W1853800668 @default.
• W2939279096 cites W1877246726 @default.
• W2939279096 cites W1883241039 @default.
• W2939279096 cites W1903960587 @default.
• W2939279096 cites W1914852136 @default.
• W2939279096 cites W1922497758 @default.
• W2939279096 cites W1951949051 @default.
• W2939279096 cites W1964174737 @default.
• W2939279096 cites W1965254104 @default.
• W2939279096 cites W1970579463 @default.
• W2939279096 cites W1971014321 @default.
• W2939279096 cites W1971125401 @default.
• W2939279096 cites W1973125755 @default.
• W2939279096 cites W1973466311 @default.
• W2939279096 cites W1975331292 @default.
• W2939279096 cites W1977247384 @default.
• W2939279096 cites W1977850361 @default.
• W2939279096 cites W1979441832 @default.
• W2939279096 cites W1979908112 @default.
• W2939279096 cites W1982298072 @default.
• W2939279096 cites W1983283649 @default.
• W2939279096 cites W1985607929 @default.
• W2939279096 cites W1986626488 @default.
• W2939279096 cites W1986911450 @default.
• W2939279096 cites W1987802538 @default.
• W2939279096 cites W1988182239 @default.
• W2939279096 cites W1993067636 @default.
• W2939279096 cites W1994609215 @default.
• W2939279096 cites W1996261857 @default.
• W2939279096 cites W1999989514 @default.
• W2939279096 cites W2000607451 @default.
• W2939279096 cites W2000825098 @default.
• W2939279096 cites W2005904867 @default.
• W2939279096 cites W2008969164 @default.
• W2939279096 cites W2009676531 @default.
• W2939279096 cites W2013262725 @default.
• W2939279096 cites W2013790022 @default.
• W2939279096 cites W2016716128 @default.
• W2939279096 cites W2020107325 @default.
• W2939279096 cites W2020977183 @default.
• W2939279096 cites W2021594631 @default.
• W2939279096 cites W2022391976 @default.
• W2939279096 cites W2022402243 @default.
• W2939279096 cites W2023449530 @default.
• W2939279096 cites W2024124235 @default.
• W2939279096 cites W2024485135 @default.
• W2939279096 cites W2025097191 @default.
• W2939279096 cites W2026626196 @default.
• W2939279096 cites W2032471499 @default.
• W2939279096 cites W2035413054 @default.
• W2939279096 cites W2035590629 @default.
• W2939279096 cites W2036934626 @default.
• W2939279096 cites W2037457092 @default.
• W2939279096 cites W2037639590 @default.
• W2939279096 cites W2037852973 @default.
• W2939279096 cites W2037857011 @default.
• W2939279096 cites W2040937016 @default.
• W2939279096 cites W2041874445 @default.
• W2939279096 cites W2043707260 @default.
• W2939279096 cites W2043765696 @default.
• W2939279096 cites W2045185962 @default.
• W2939279096 cites W2045286159 @default.
• W2939279096 cites W2046127215 @default.
• W2939279096 cites W2047831967 @default.
• W2939279096 cites W2048047693 @default.
• W2939279096 cites W2053170041 @default.
• W2939279096 cites W2054749214 @default.
• W2939279096 cites W2055722215 @default.
• W2939279096 cites W2056251473 @default.
• W2939279096 cites W2057226590 @default.
• W2939279096 cites W2057536623 @default.
• W2939279096 cites W2060938551 @default.
• W2939279096 cites W2061600370 @default.
• W2939279096 cites W2062195428 @default.
• W2939279096 cites W2063753583 @default.
• W2939279096 cites W2067690062 @default.
• W2939279096 cites W2068400560 @default.
• W2939279096 cites W2075247829 @default.
• W2939279096 cites W2078845670 @default.
• W2939279096 cites W2079828968 @default.
• W2939279096 cites W2080055692 @default.
• W2939279096 cites W2080811986 @default.
• W2939279096 cites W2084035844 @default.

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