FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2939544187> ?p ?o ?g. }

• W2939544187 endingPage "6410" @default.
• W2939544187 startingPage "6396" @default.
• W2939544187 abstract "Abstract Ribosome-mediated transcription attenuation is a basic posttranscriptional regulation mechanism in bacteria. Liberated attenuator RNAs arising in this process are generally considered nonfunctional. In Sinorhizobium meliloti, the tryptophan (Trp) biosynthesis genes are organized into three operons, trpE(G), ppiD-trpDC-moaC-moeA, and trpFBA-accD-folC, of which only the first one, trpE(G), contains a short ORF (trpL) in the 5′-UTR and is regulated by transcription attenuation. Under conditions of Trp sufficiency, transcription is terminated between trpL and trpE(G), and a small attenuator RNA, rnTrpL, is produced. Here, we show that rnTrpL base-pairs with trpD and destabilizes the polycistronic trpDC mRNA, indicating rnTrpL-mediated downregulation of the trpDC operon in trans. Although all three trp operons are regulated in response to Trp availability, only in the two operons trpE(G) and trpDC the Trp-mediated regulation is controlled by rnTrpL. Together, our data show that the trp attenuator coordinates trpE(G) and trpDC expression posttranscriptionally by two fundamentally different mechanisms: ribosome-mediated transcription attenuation in cis and base-pairing in trans. Also, we present evidence that rnTrpL-mediated regulation of trpDC genes expression in trans is conserved in Agrobacterium and Bradyrhizobium, suggesting that the small attenuator RNAs may have additional conserved functions in the control of bacterial gene expression." @default.
• W2939544187 created "2019-04-25" @default.
• W2939544187 creator A5001242993 @default.
• W2939544187 creator A5012443982 @default.
• W2939544187 creator A5017650735 @default.
• W2939544187 creator A5019457955 @default.
• W2939544187 creator A5033077936 @default.
• W2939544187 creator A5033496733 @default.
• W2939544187 creator A5037220101 @default.
• W2939544187 creator A5046162299 @default.
• W2939544187 creator A5076640513 @default.
• W2939544187 date "2019-04-17" @default.
• W2939544187 modified "2023-10-15" @default.
• W2939544187 title "Transcription attenuation-derived small RNA rnTrpL regulates tryptophan biosynthesis gene expression in trans" @default.
• W2939544187 cites W1561074056 @default.
• W2939544187 cites W1599791669 @default.
• W2939544187 cites W1919999409 @default.
• W2939544187 cites W1921406710 @default.
• W2939544187 cites W1967602156 @default.
• W2939544187 cites W1972777904 @default.
• W2939544187 cites W1974251842 @default.
• W2939544187 cites W1976295198 @default.
• W2939544187 cites W1977448000 @default.
• W2939544187 cites W1982926661 @default.
• W2939544187 cites W1983075043 @default.
• W2939544187 cites W1983314769 @default.
• W2939544187 cites W1992050565 @default.
• W2939544187 cites W1993234114 @default.
• W2939544187 cites W1996974387 @default.
• W2939544187 cites W1999815828 @default.
• W2939544187 cites W2002291873 @default.
• W2939544187 cites W2002473282 @default.
• W2939544187 cites W2005659759 @default.
• W2939544187 cites W2009015416 @default.
• W2939544187 cites W2009026991 @default.
• W2939544187 cites W2013271543 @default.
• W2939544187 cites W2013792518 @default.
• W2939544187 cites W2013880673 @default.
• W2939544187 cites W2027229485 @default.
• W2939544187 cites W2028102516 @default.
• W2939544187 cites W2028622989 @default.
• W2939544187 cites W2031981077 @default.
• W2939544187 cites W2044410490 @default.
• W2939544187 cites W2046374424 @default.
• W2939544187 cites W2049918812 @default.
• W2939544187 cites W2059748132 @default.
• W2939544187 cites W2065637677 @default.
• W2939544187 cites W2084379120 @default.
• W2939544187 cites W2086561953 @default.
• W2939544187 cites W2090900888 @default.
• W2939544187 cites W2095935008 @default.
• W2939544187 cites W2097661679 @default.
• W2939544187 cites W2098508116 @default.
• W2939544187 cites W2104702173 @default.
• W2939544187 cites W2108244474 @default.
• W2939544187 cites W2113108919 @default.
• W2939544187 cites W2123643844 @default.
• W2939544187 cites W2127969464 @default.
• W2939544187 cites W2128613900 @default.
• W2939544187 cites W2131330686 @default.
• W2939544187 cites W2141157874 @default.
• W2939544187 cites W2143407915 @default.
• W2939544187 cites W2144362290 @default.
• W2939544187 cites W2145023650 @default.
• W2939544187 cites W2148118616 @default.
• W2939544187 cites W2151857795 @default.
• W2939544187 cites W2153076508 @default.
• W2939544187 cites W2154531880 @default.
• W2939544187 cites W2156644393 @default.
• W2939544187 cites W2157640072 @default.
• W2939544187 cites W2158557527 @default.
• W2939544187 cites W2160947128 @default.
• W2939544187 cites W2164075295 @default.
• W2939544187 cites W2168420558 @default.
• W2939544187 cites W2197714468 @default.
• W2939544187 cites W2223269434 @default.
• W2939544187 cites W2340274683 @default.
• W2939544187 cites W2554884413 @default.
• W2939544187 cites W2593735764 @default.
• W2939544187 cites W2600054520 @default.
• W2939544187 cites W2605469181 @default.
• W2939544187 cites W2617073147 @default.
• W2939544187 cites W2766275421 @default.
• W2939544187 cites W2772685483 @default.
• W2939544187 cites W2803009165 @default.
• W2939544187 cites W2888846369 @default.
• W2939544187 cites W2906358839 @default.
• W2939544187 doi "https://doi.org/10.1093/nar/gkz274" @default.
• W2939544187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6614838" @default.
• W2939544187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30993322" @default.
• W2939544187 hasPublicationYear "2019" @default.
• W2939544187 type Work @default.
• W2939544187 sameAs 2939544187 @default.
• W2939544187 citedByCount "22" @default.
• W2939544187 countsByYear W29395441872019 @default.
• W2939544187 countsByYear W29395441872020 @default.
• W2939544187 countsByYear W29395441872021 @default.
• W2939544187 countsByYear W29395441872022 @default.

• next