Matches in SemOpenAlex for { <https://semopenalex.org/work/W2939545541> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2939545541 endingPage "81" @default.
- W2939545541 startingPage "70" @default.
- W2939545541 abstract "Artificial sweeteners have been in use by food industries for a long time. Safety concerns raised about artificial sweeteners since they are widely used nowadays. The present work aims to study the possible changes in body weight, blood picture, liver functions, blood glucose and liver glycogen content as well as histopathological changes induced in liver and urinary bladder of male albino rats after administration of two artificial sweeteners (saccharin or aspartame). Male rats were administered saccharin (50 mg/kg b.w.) or aspartame (100 mg/kg b.w.) daily by intragastric gavage for 14 weeks. The results revealed that both saccharin and aspartame provoked highly significant reduction in body weight gain %. Saccharin exerted highly significant reduction in haemoglobin (Hb) level, haematocrit (Hct%) and red blood cells (RBCs) count, while aspartame induced insignificant changes in all haematological parameters. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity levels were significantly increased with saccharin and aspartame. Alkaline phosphatase (ALP) levels in serum showed slightly insignificant increase by saccharim administration, while aspartame caused a significant rise in ALP. Blood glucose level of rats given saccharin significantly dropped, while aspartame caused a significant elevation in blood glucose level. Liver glycogen content of rats given saccharin significantly increased, while aspartame caused a significant reduction in liver glycogen content. Microscopic examination of liver sections showed lymphocytic and macrophages infiltration of the portal traid in rats administered saccharin, while aspartame group showed no histopathological changes except slight hydropic degeneration of hepatocytes. Urinary bladder sections of rats administered saccharin revealed proliferation of the mucosal epithelial cells into papillary invaginated projections with highly vascularized connective tissue core and mononuclear inflammatory cells infiltration, while aspartame group showed no histopahtological alterations. It could be recommended that the use of saccharin as an artificial sweetener should be restricted, while aspartame should not be administered to diabetic. When it is necessary to use artificial sweeteners, fresh fruits and vegetables should be ingested as they act as scavengers for the liberated free radicals and help to delay the postprandial rise in blood glucose level." @default.
- W2939545541 created "2019-04-25" @default.
- W2939545541 creator A5002869528 @default.
- W2939545541 date "2002-07-01" @default.
- W2939545541 modified "2023-09-24" @default.
- W2939545541 title "Physiological Changes Induced by Long Term Administration of Saccharin Compared with Aspartame to Male Albino Rats" @default.
- W2939545541 cites W1234143761 @default.
- W2939545541 cites W1503393361 @default.
- W2939545541 cites W1534365114 @default.
- W2939545541 cites W1831301545 @default.
- W2939545541 cites W1949298326 @default.
- W2939545541 cites W199283095 @default.
- W2939545541 cites W20028283 @default.
- W2939545541 cites W2007721053 @default.
- W2939545541 cites W2027268952 @default.
- W2939545541 cites W2041696384 @default.
- W2939545541 cites W2042451014 @default.
- W2939545541 cites W2087329760 @default.
- W2939545541 cites W2148011531 @default.
- W2939545541 cites W2234571365 @default.
- W2939545541 cites W2263023695 @default.
- W2939545541 cites W2303384341 @default.
- W2939545541 cites W2335809840 @default.
- W2939545541 cites W2345912267 @default.
- W2939545541 cites W3112727996 @default.
- W2939545541 doi "https://doi.org/10.12816/ejhm.2002.18747" @default.
- W2939545541 hasPublicationYear "2002" @default.
- W2939545541 type Work @default.
- W2939545541 sameAs 2939545541 @default.
- W2939545541 citedByCount "4" @default.
- W2939545541 countsByYear W29395455412016 @default.
- W2939545541 countsByYear W29395455412018 @default.
- W2939545541 countsByYear W29395455412019 @default.
- W2939545541 crossrefType "journal-article" @default.
- W2939545541 hasAuthorship W2939545541A5002869528 @default.
- W2939545541 hasConcept C126322002 @default.
- W2939545541 hasConcept C134018914 @default.
- W2939545541 hasConcept C160160445 @default.
- W2939545541 hasConcept C181199279 @default.
- W2939545541 hasConcept C185592680 @default.
- W2939545541 hasConcept C2777108408 @default.
- W2939545541 hasConcept C2777499176 @default.
- W2939545541 hasConcept C2778278337 @default.
- W2939545541 hasConcept C2779147919 @default.
- W2939545541 hasConcept C2911055575 @default.
- W2939545541 hasConcept C55493867 @default.
- W2939545541 hasConcept C71924100 @default.
- W2939545541 hasConcept C77411442 @default.
- W2939545541 hasConceptScore W2939545541C126322002 @default.
- W2939545541 hasConceptScore W2939545541C134018914 @default.
- W2939545541 hasConceptScore W2939545541C160160445 @default.
- W2939545541 hasConceptScore W2939545541C181199279 @default.
- W2939545541 hasConceptScore W2939545541C185592680 @default.
- W2939545541 hasConceptScore W2939545541C2777108408 @default.
- W2939545541 hasConceptScore W2939545541C2777499176 @default.
- W2939545541 hasConceptScore W2939545541C2778278337 @default.
- W2939545541 hasConceptScore W2939545541C2779147919 @default.
- W2939545541 hasConceptScore W2939545541C2911055575 @default.
- W2939545541 hasConceptScore W2939545541C55493867 @default.
- W2939545541 hasConceptScore W2939545541C71924100 @default.
- W2939545541 hasConceptScore W2939545541C77411442 @default.
- W2939545541 hasIssue "1" @default.
- W2939545541 hasLocation W29395455411 @default.
- W2939545541 hasOpenAccess W2939545541 @default.
- W2939545541 hasPrimaryLocation W29395455411 @default.
- W2939545541 hasRelatedWork W1915513917 @default.
- W2939545541 hasRelatedWork W1965503885 @default.
- W2939545541 hasRelatedWork W1970748077 @default.
- W2939545541 hasRelatedWork W1996818013 @default.
- W2939545541 hasRelatedWork W2017385818 @default.
- W2939545541 hasRelatedWork W2021396540 @default.
- W2939545541 hasRelatedWork W2066118537 @default.
- W2939545541 hasRelatedWork W2085574122 @default.
- W2939545541 hasRelatedWork W2086326247 @default.
- W2939545541 hasRelatedWork W2314953165 @default.
- W2939545541 hasRelatedWork W2380477083 @default.
- W2939545541 hasRelatedWork W2416978874 @default.
- W2939545541 hasRelatedWork W2479102382 @default.
- W2939545541 hasRelatedWork W2953901472 @default.
- W2939545541 hasRelatedWork W3025094399 @default.
- W2939545541 hasRelatedWork W3088284687 @default.
- W2939545541 hasRelatedWork W3208439272 @default.
- W2939545541 hasRelatedWork W3214386995 @default.
- W2939545541 hasRelatedWork W2415412410 @default.
- W2939545541 hasRelatedWork W3189937280 @default.
- W2939545541 hasVolume "8" @default.
- W2939545541 isParatext "false" @default.
- W2939545541 isRetracted "false" @default.
- W2939545541 magId "2939545541" @default.
- W2939545541 workType "article" @default.