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- W2939565595 abstract "Virus can induce vitiligo but the mechanism is elusive. Melanoma differentiation-associated gene 5 (MDA5) functions as one of the major sensors of RNA viruses. IFIH1, which encodes the MDA5 protein, has been newly identified as a susceptibility gene in vitiligo. Nevertheless, little is known about the function and mechanism of MDA5 in the onset and progress of vitiligo. We demonstrated here that MDA5 expression increased using immunofluorescence in vitiligo lesions and showed a positive correlation with severity of patients with vitiligo. In addition, as a viral nucleic acid analog, Poly (I:C) can increase the expression of CXCL10, CXCL16 and CCL20 in a MDA5-dependant way. Further more, through knock-down assay using si-RNA, we found poly(I:C)-induced chemokines secretion was due to the activation of MDA5-MAVS-NF-kb pathway. Finally, These chemokines produced by keratinocytes induced migration of autoreactive CD8+ T cells derived from patients with vitiligo, which features the pathology of vitiligo. In summary, we demonstrated that MDA5 mediates CD8+ T-cell skin trafficking under virus infection through the section of chemokines such as CXCL10, CXCL16 and CCL20 in patients with vitiligo. This effect is caused by MDA5-MAVS-NF-kB pathway. This research may provide a new extension of how virus induce the onset and development of vitiligo." @default.
- W2939565595 created "2019-04-25" @default.
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- W2939565595 date "2019-05-01" @default.
- W2939565595 modified "2023-10-16" @default.
- W2939565595 title "808 The function and mechanism of MDA5 in the onset and progress of virus-induced vitiligo" @default.
- W2939565595 doi "https://doi.org/10.1016/j.jid.2019.03.884" @default.
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