Matches in SemOpenAlex for { <https://semopenalex.org/work/W2939604020> ?p ?o ?g. }
- W2939604020 abstract "Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states. Phagocytosis is a highly complex process that is specialized for the uptake and removal of opsonized and non-opsonized targets, such as pathogens, apoptotic cells, and cellular debris. While the role of phagocytosis in mediating classical innate and adaptive immune responses has been known for decades, it is now appreciated that phagocytosis is also critical throughout early neural development, homeostasis, and initiating repair mechanisms. As such, modulating phagocytic processes has provided unexplored avenues with the intent of developing novel therapeutics that promote repair and regeneration in the CNS. Here, we review the functional consequences that phagocytosis plays in both the healthy and diseased CNS, and summarize how phagocytosis contributes to overall pathophysiological mechanisms involved in brain injury and repair." @default.
- W2939604020 created "2019-04-25" @default.
- W2939604020 creator A5012819778 @default.
- W2939604020 creator A5056424425 @default.
- W2939604020 creator A5066951305 @default.
- W2939604020 creator A5077969006 @default.
- W2939604020 date "2019-04-16" @default.
- W2939604020 modified "2023-10-14" @default.
- W2939604020 title "Phagocytosis in the Brain: Homeostasis and Disease" @default.
- W2939604020 cites W1456373634 @default.
- W2939604020 cites W1494319831 @default.
- W2939604020 cites W1496307550 @default.
- W2939604020 cites W1560622241 @default.
- W2939604020 cites W1595413626 @default.
- W2939604020 cites W1615922199 @default.
- W2939604020 cites W1616122655 @default.
- W2939604020 cites W1770378670 @default.
- W2939604020 cites W1832818975 @default.
- W2939604020 cites W1928993351 @default.
- W2939604020 cites W1964848350 @default.
- W2939604020 cites W1966113514 @default.
- W2939604020 cites W1966831629 @default.
- W2939604020 cites W1972097907 @default.
- W2939604020 cites W1974172728 @default.
- W2939604020 cites W1975386426 @default.
- W2939604020 cites W1980789245 @default.
- W2939604020 cites W1981142987 @default.
- W2939604020 cites W1984503507 @default.
- W2939604020 cites W1988650085 @default.
- W2939604020 cites W1990752558 @default.
- W2939604020 cites W1993057071 @default.
- W2939604020 cites W1996199386 @default.
- W2939604020 cites W1997816650 @default.
- W2939604020 cites W1999631936 @default.
- W2939604020 cites W2002267815 @default.
- W2939604020 cites W2005500002 @default.
- W2939604020 cites W2005731595 @default.
- W2939604020 cites W2006517495 @default.
- W2939604020 cites W2008082211 @default.
- W2939604020 cites W2008613303 @default.
- W2939604020 cites W2008987889 @default.
- W2939604020 cites W2009639401 @default.
- W2939604020 cites W2010464023 @default.
- W2939604020 cites W2011041653 @default.
- W2939604020 cites W2011142778 @default.
- W2939604020 cites W2014200126 @default.
- W2939604020 cites W2017867302 @default.
- W2939604020 cites W2018626218 @default.
- W2939604020 cites W2019249853 @default.
- W2939604020 cites W2023053568 @default.
- W2939604020 cites W2025461456 @default.
- W2939604020 cites W2026279003 @default.
- W2939604020 cites W2026397702 @default.
- W2939604020 cites W2027460468 @default.
- W2939604020 cites W2027467386 @default.
- W2939604020 cites W2028167589 @default.
- W2939604020 cites W2033617297 @default.
- W2939604020 cites W2035221144 @default.
- W2939604020 cites W2038594716 @default.
- W2939604020 cites W2040547343 @default.
- W2939604020 cites W2040719456 @default.
- W2939604020 cites W2040898123 @default.
- W2939604020 cites W2041785681 @default.
- W2939604020 cites W2042991275 @default.
- W2939604020 cites W2045720033 @default.
- W2939604020 cites W2049578043 @default.
- W2939604020 cites W2051639780 @default.
- W2939604020 cites W2052652421 @default.
- W2939604020 cites W2055568011 @default.
- W2939604020 cites W2058478749 @default.
- W2939604020 cites W2059028717 @default.
- W2939604020 cites W2060061788 @default.
- W2939604020 cites W2060678482 @default.
- W2939604020 cites W2060915232 @default.
- W2939604020 cites W2061771806 @default.
- W2939604020 cites W2063127941 @default.
- W2939604020 cites W2066329953 @default.
- W2939604020 cites W2066943555 @default.
- W2939604020 cites W2069121057 @default.
- W2939604020 cites W2072247054 @default.
- W2939604020 cites W2074502503 @default.
- W2939604020 cites W2075463100 @default.
- W2939604020 cites W2076751578 @default.
- W2939604020 cites W2077387648 @default.
- W2939604020 cites W2079225413 @default.
- W2939604020 cites W2081982964 @default.
- W2939604020 cites W2083799755 @default.
- W2939604020 cites W2085217436 @default.
- W2939604020 cites W2087243986 @default.
- W2939604020 cites W2090134990 @default.
- W2939604020 cites W2090305293 @default.
- W2939604020 cites W2091455355 @default.
- W2939604020 cites W2092809740 @default.
- W2939604020 cites W2092935640 @default.
- W2939604020 cites W2094044389 @default.
- W2939604020 cites W2094470133 @default.
- W2939604020 cites W2094660330 @default.
- W2939604020 cites W2094831055 @default.
- W2939604020 cites W2095339919 @default.
- W2939604020 cites W2095444837 @default.