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- W2939710257 abstract "Abstract Objectives Proton‐pump inhibitor (PPI) prescribing practices in laryngopharyngeal reflux disease (LPR) differ among physicians. We assessed the improvement in reflux symptom index (RSI) and reflux finding score (RFS) after treating LPR with three different regimens. Design A prospective, double‐blind, randomized clinical trial. Setting Chungnam national university hospital in Korea. Participants From July 2015 to July 2017, 100 patients with LPR included in the study. The patients were prescribed one of the following regimens for 3 months: group A, ilaprazole 10 mg, once a day (QD), n = 29; group B, ilaprazole 10 mg, twice a day (BID), n = 27; and group C, ilaprazole 10 mg BID plus mosapride citrate 5 mg three times a day (TID), n = 44. Main outcome measures The total RSI and RFS scores and each subitems in RSI and FRS of the patients were evaluated. Results Total RFS and RSI scores improved significantly at the 3‐month follow‐up in all groups, and the improvements were of similar magnitudes. Regarding the RFS, the degrees of improvement in vocal cord oedema ( P = 0.002) and diffuse laryngeal oedema ( P = 0.003) scores differed significantly among the three groups. Moreover, overweight or obese patients in group C showed the greatest improvement in RFS. However, age had no effect on treatment efficacy. Conclusion Three PPI therapeutic strategies showed similar efficacies against LPR according to total RFS and RSI scores. The addition of a prokinetic resulted in improvements in specific endoscopic findings, such as vocal cord oedema and diffuse laryngeal oedema. Furthermore, the addition of a prokinetic to PPI therapy was particularly beneficial for overweight or obese patients." @default.
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- W2939710257 date "2019-05-06" @default.
- W2939710257 modified "2023-10-16" @default.
- W2939710257 title "Efficacy of three proton‐pump inhibitor therapeutic strategies on laryngopharyngeal reflux disease; a prospective randomized double‐blind study" @default.
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- W2939710257 doi "https://doi.org/10.1111/coa.13345" @default.
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