FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2939720838> ?p ?o ?g. }

• W2939720838 endingPage "49" @default.
• W2939720838 startingPage "35" @default.
• W2939720838 abstract "Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a possible functional connection between UCP1 and sirtuin 3 (SIRT3), the master mitochondrial lysine deacetylase. We carried out physiological, molecular, and proteomic analyses of BAT from wild-type and Sirt3KO mice when BAT is activated. Mice were either cold exposed for 2 days or were injected with the β3-adrenergic agonist, CL316,243 (1 mg/kg; i.p.). Mutagenesis studies were conducted in a cellular model to assess the impact of acetylation lysine sites on UCP1 function. Cardiac punctures were collected for proteomic analysis of blood acylcarnitines. Isolated mitochondria were used for functional analysis of OXPHOS proteins. Our findings showed that SIRT3 absence in mice resulted in impaired BAT lipid use, whole body thermoregulation, and respiration in BAT mitochondria, without affecting UCP1 expression. Acetylome profiling of BAT mitochondria revealed that SIRT3 regulates acetylation status of many BAT mitochondrial proteins including UCP1 and crucial upstream proteins. Mutagenesis work in cells suggested that UCP1 activity was independent of direct SIRT3-regulated lysine acetylation. However, SIRT3 impacted BAT mitochondrial proteins activities of acylcarnitine metabolism and specific electron transport chain complexes, CI and CII. Our data highlight that SIRT3 likely controls BAT thermogenesis indirectly by targeting pathways upstream of UCP1." @default.
• W2939720838 created "2019-04-25" @default.
• W2939720838 creator A5018282795 @default.
• W2939720838 creator A5018840106 @default.
• W2939720838 creator A5025922182 @default.
• W2939720838 creator A5026080576 @default.
• W2939720838 creator A5026493421 @default.
• W2939720838 creator A5043986649 @default.
• W2939720838 creator A5059961736 @default.
• W2939720838 creator A5065196920 @default.
• W2939720838 creator A5069757786 @default.
• W2939720838 creator A5084639135 @default.
• W2939720838 creator A5085066288 @default.
• W2939720838 creator A5088993735 @default.
• W2939720838 creator A5089120083 @default.
• W2939720838 date "2019-07-01" @default.
• W2939720838 modified "2023-10-08" @default.
• W2939720838 title "SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1" @default.
• W2939720838 cites W1503600099 @default.
• W2939720838 cites W1550000221 @default.
• W2939720838 cites W1762535185 @default.
• W2939720838 cites W1900866157 @default.
• W2939720838 cites W1920447776 @default.
• W2939720838 cites W1965935659 @default.
• W2939720838 cites W1972802538 @default.
• W2939720838 cites W1979815517 @default.
• W2939720838 cites W1983872288 @default.
• W2939720838 cites W1985834536 @default.
• W2939720838 cites W2002696989 @default.
• W2939720838 cites W2009785737 @default.
• W2939720838 cites W2013841882 @default.
• W2939720838 cites W2014352876 @default.
• W2939720838 cites W2043054174 @default.
• W2939720838 cites W2051516736 @default.
• W2939720838 cites W2052751736 @default.
• W2939720838 cites W2056673958 @default.
• W2939720838 cites W2062073832 @default.
• W2939720838 cites W2064612269 @default.
• W2939720838 cites W2075748926 @default.
• W2939720838 cites W2077132863 @default.
• W2939720838 cites W2080752012 @default.
• W2939720838 cites W2088511656 @default.
• W2939720838 cites W2092897692 @default.
• W2939720838 cites W2098574158 @default.
• W2939720838 cites W2101065953 @default.
• W2939720838 cites W2105770392 @default.
• W2939720838 cites W2108335191 @default.
• W2939720838 cites W2114165700 @default.
• W2939720838 cites W2115941382 @default.
• W2939720838 cites W2117473844 @default.
• W2939720838 cites W2121532196 @default.
• W2939720838 cites W2131762758 @default.
• W2939720838 cites W2132358997 @default.
• W2939720838 cites W2136689463 @default.
• W2939720838 cites W2146614096 @default.
• W2939720838 cites W2147627509 @default.
• W2939720838 cites W2149168300 @default.
• W2939720838 cites W2149626160 @default.
• W2939720838 cites W2151470490 @default.
• W2939720838 cites W2155843473 @default.
• W2939720838 cites W2159266328 @default.
• W2939720838 cites W2159430439 @default.
• W2939720838 cites W2162023168 @default.
• W2939720838 cites W2162186867 @default.
• W2939720838 cites W2165033636 @default.
• W2939720838 cites W2166900325 @default.
• W2939720838 cites W2167279371 @default.
• W2939720838 cites W2169880855 @default.
• W2939720838 cites W2191641478 @default.
• W2939720838 cites W2242613625 @default.
• W2939720838 cites W2253911195 @default.
• W2939720838 cites W2262264910 @default.
• W2939720838 cites W2302526767 @default.
• W2939720838 cites W2316741386 @default.
• W2939720838 cites W2332777704 @default.
• W2939720838 cites W2605190264 @default.
• W2939720838 cites W2762948888 @default.
• W2939720838 cites W2764017545 @default.
• W2939720838 cites W2883879320 @default.
• W2939720838 cites W2899760200 @default.
• W2939720838 cites W2919162898 @default.
• W2939720838 doi "https://doi.org/10.1016/j.molmet.2019.04.008" @default.
• W2939720838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6601363" @default.
• W2939720838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31060926" @default.
• W2939720838 hasPublicationYear "2019" @default.
• W2939720838 type Work @default.
• W2939720838 sameAs 2939720838 @default.
• W2939720838 citedByCount "29" @default.
• W2939720838 countsByYear W29397208382019 @default.
• W2939720838 countsByYear W29397208382020 @default.
• W2939720838 countsByYear W29397208382021 @default.
• W2939720838 countsByYear W29397208382022 @default.
• W2939720838 countsByYear W29397208382023 @default.
• W2939720838 crossrefType "journal-article" @default.
• W2939720838 hasAuthorship W2939720838A5018282795 @default.
• W2939720838 hasAuthorship W2939720838A5018840106 @default.
• W2939720838 hasAuthorship W2939720838A5025922182 @default.
• W2939720838 hasAuthorship W2939720838A5026080576 @default.

• next