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- W2939776481 abstract "To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation.We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate.Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups.In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn." @default.
- W2939776481 created "2019-04-25" @default.
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- W2939776481 date "2019-02-06" @default.
- W2939776481 modified "2023-10-18" @default.
- W2939776481 title "The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis" @default.
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- W2939776481 doi "https://doi.org/10.1186/s12958-019-0460-4" @default.
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