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• W2939779971 abstract "<b><i>Background and Purpose:</i></b> The role played by post-stroke inflammation after an ischemic event in limiting functional recovery remains unclear. One component of post-stroke inflammation is disruption of the blood-brain barrier (BBB). This study examines the relationship between post-stroke BBB disruption and functional outcome. <b><i>Methods:</i></b> Acute stroke patients treated with thrombolysis underwent magnetic resonance imaging scanning 24 h and 5 days after their initial event. BBB permeability maps were generated from perfusion weighted imaging. Average permeability was calculated in the affected hemisphere. Good functional outcome, defined as a modified Rankin score of 0 or 1, was compared with average permeability using logistic regression. <b><i>Results:</i></b> Of the 131 patients enrolled, 76 patients had the necessary data to perform the analysis at 24 h, and 58 ­patients had data for the 5-day assessment. Higher BBB permeability measured at 24 h (OR 0.57; 95% CI 0.33–0.99, <i>p</i> = 0.045) and at 5 days (OR 0.24; 95% CI 0.09–0.66, <i>p</i> = 0.005) was associated with worse functional outcome 1–3 months after the acute ischemic stroke. For every percentage increase in BBB disruption at 5 days, there was a 76% decrease in the chance of achieving a good functional outcome after stroke. Multivariate analysis found this to be independent of age, stroke volume, or clinical stroke severity. <b><i>Conclusions:</i></b> Post-stroke BBB disruption appears to be predictive of functional outcome irrespective of stroke size." @default.
• W2939779971 created "2019-04-25" @default.
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• W2939779971 date "2019-01-01" @default.
• W2939779971 modified "2023-10-05" @default.
• W2939779971 title "Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy" @default.
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• W2939779971 doi "https://doi.org/10.1159/000499666" @default.
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