Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940032148> ?p ?o ?g. }
- W2940032148 endingPage "704" @default.
- W2940032148 startingPage "687" @default.
- W2940032148 abstract "The aim of this study was to reveal the biological activities and in vivo toxicity profiles of n-hexane, chloroform and methanol extracts of brown algae Halopteris scoparia L. Sauvageau. In this study, extracts were tested for their phytochemical contents and antioxidant activities. The cytotoxic activities of the extracts against cervical adenocarcinoma (HeLa), colon colorectal adenocarcinoma (CaCo-2) and breast adenocarcinoma (MCF7) cells were assessed by MTT assay and total RNAs derived from cell lines to analyze gene expression were analyzed by Real Time Ready Human Apoptosis Panel 96. Also, in vivo toxicity and irritation effects of extracts were evaluated by LD50 acute toxicity test and Hen's egg test chorioallantoic membrane (HET-CAM) assay, respectively. Our results showed that the phenolic and flavonoid contents were determined only in methanol extract (33.20 ± 1.41 mg GAE/g and 1.26 ± 0.95 mg QE/g). Also, n-hexane has a broader spectrum of content than methanol and chloroform extracts. Furthermore, n-hexane extract in DPPH and methanol extract in ABTS+ exhibited the best antioxidant activity. In addition, MTT results revealed that each three extracts cause a significant reduction in cell viability, especially in HeLa cells. When the apoptotic gene expressions were examined after treatment of extracts, the expression of many pro-apoptotic genes in both caspase-independent and caspase-dependent intrinsic and extrinsic pathways increased. These findings suggest that, considering that it had not led to irritation and toxicity in vivo, edible H. scoparia is a natural antioxidant and its apoptotic/cytotoxic activities can potentially be used against human cancers." @default.
- W2940032148 created "2019-04-25" @default.
- W2940032148 creator A5018950515 @default.
- W2940032148 creator A5023142927 @default.
- W2940032148 creator A5055215386 @default.
- W2940032148 creator A5069194185 @default.
- W2940032148 date "2019-04-09" @default.
- W2940032148 modified "2023-10-11" @default.
- W2940032148 title "Apoptosis-inducing activities of Halopteris scoparia L. Sauvageau (Brown algae) on cancer cells and its biosafety and antioxidant properties" @default.
- W2940032148 cites W1965565026 @default.
- W2940032148 cites W1978668430 @default.
- W2940032148 cites W1979842763 @default.
- W2940032148 cites W1980924993 @default.
- W2940032148 cites W1984358846 @default.
- W2940032148 cites W1985931135 @default.
- W2940032148 cites W1991865867 @default.
- W2940032148 cites W1992716708 @default.
- W2940032148 cites W1997160355 @default.
- W2940032148 cites W2010728731 @default.
- W2940032148 cites W2012991711 @default.
- W2940032148 cites W2017407392 @default.
- W2940032148 cites W2018692723 @default.
- W2940032148 cites W2021074776 @default.
- W2940032148 cites W2022803736 @default.
- W2940032148 cites W2025128734 @default.
- W2940032148 cites W2043428504 @default.
- W2940032148 cites W2043855273 @default.
- W2940032148 cites W2045278102 @default.
- W2940032148 cites W2055508057 @default.
- W2940032148 cites W2056239762 @default.
- W2940032148 cites W2058920377 @default.
- W2940032148 cites W2060093563 @default.
- W2940032148 cites W2061690334 @default.
- W2940032148 cites W2061795006 @default.
- W2940032148 cites W2065518779 @default.
- W2940032148 cites W2072380594 @default.
- W2940032148 cites W2087454739 @default.
- W2940032148 cites W2107277218 @default.
- W2940032148 cites W2111139603 @default.
- W2940032148 cites W2113999599 @default.
- W2940032148 cites W2114918609 @default.
- W2940032148 cites W2118308470 @default.
- W2940032148 cites W2125648408 @default.
- W2940032148 cites W2151392138 @default.
- W2940032148 cites W2153420868 @default.
- W2940032148 cites W2155226889 @default.
- W2940032148 cites W2158373947 @default.
- W2940032148 cites W2161229173 @default.
- W2940032148 cites W2169637929 @default.
- W2940032148 cites W2169684622 @default.
- W2940032148 cites W2192080449 @default.
- W2940032148 cites W2412954705 @default.
- W2940032148 cites W2804861256 @default.
- W2940032148 cites W2898899488 @default.
- W2940032148 cites W4366071542 @default.
- W2940032148 cites W55025327 @default.
- W2940032148 doi "https://doi.org/10.1007/s10616-019-00314-5" @default.
- W2940032148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6546795" @default.
- W2940032148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30969390" @default.
- W2940032148 hasPublicationYear "2019" @default.
- W2940032148 type Work @default.
- W2940032148 sameAs 2940032148 @default.
- W2940032148 citedByCount "17" @default.
- W2940032148 countsByYear W29400321482020 @default.
- W2940032148 countsByYear W29400321482021 @default.
- W2940032148 countsByYear W29400321482022 @default.
- W2940032148 countsByYear W29400321482023 @default.
- W2940032148 crossrefType "journal-article" @default.
- W2940032148 hasAuthorship W2940032148A5018950515 @default.
- W2940032148 hasAuthorship W2940032148A5023142927 @default.
- W2940032148 hasAuthorship W2940032148A5055215386 @default.
- W2940032148 hasAuthorship W2940032148A5069194185 @default.
- W2940032148 hasBestOaLocation W29400321482 @default.
- W2940032148 hasConcept C109316439 @default.
- W2940032148 hasConcept C1491633281 @default.
- W2940032148 hasConcept C150903083 @default.
- W2940032148 hasConcept C178790620 @default.
- W2940032148 hasConcept C185592680 @default.
- W2940032148 hasConcept C190283241 @default.
- W2940032148 hasConcept C202751555 @default.
- W2940032148 hasConcept C207001950 @default.
- W2940032148 hasConcept C2777366897 @default.
- W2940032148 hasConcept C2778004101 @default.
- W2940032148 hasConcept C2780783641 @default.
- W2940032148 hasConcept C2781401929 @default.
- W2940032148 hasConcept C29730261 @default.
- W2940032148 hasConcept C53227056 @default.
- W2940032148 hasConcept C55493867 @default.
- W2940032148 hasConcept C556039675 @default.
- W2940032148 hasConcept C71924100 @default.
- W2940032148 hasConcept C86803240 @default.
- W2940032148 hasConcept C98274493 @default.
- W2940032148 hasConceptScore W2940032148C109316439 @default.
- W2940032148 hasConceptScore W2940032148C1491633281 @default.
- W2940032148 hasConceptScore W2940032148C150903083 @default.
- W2940032148 hasConceptScore W2940032148C178790620 @default.
- W2940032148 hasConceptScore W2940032148C185592680 @default.
- W2940032148 hasConceptScore W2940032148C190283241 @default.