Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940171567> ?p ?o ?g. }
- W2940171567 endingPage "1830" @default.
- W2940171567 startingPage "1830" @default.
- W2940171567 abstract "The granted European patent EP 2 561 890 describes a procedure for an immunological treatment of cancer. It is based on the principles of the HLA-supported communication of implantation and pregnancy. These principles ensure that the embryo is not rejected by the mother. In pregnancy, the placenta, more specifically the trophoblast, creates an “interface” between the embryo/fetus and the maternal immune system. Trophoblasts do not express the “original” HLA identification of the embryo/fetus (HLA-A to -DQ), but instead show the non-classical HLA groups E, F, and G. During interaction with specific receptors of NK cells (e.g., killer-immunoglobulin-like receptors (KIR)) and lymphocytes (lymphocyte-immunoglobulin-like receptors (LIL-R)), the non-classical HLA groups inhibit these immunocompetent cells outside pregnancy. However, tumors are known to be able to express these non-classical HLA groups and thus make use of an immuno-communication as in pregnancies. If this occurs, the prognosis usually worsens. This patent describes, in a first step, the profiling of the non-classical HLA groups in primary tumor tissue as well as metastases and recurrent tumors. The second step comprises tailored antibody therapies, which is the subject of this patent. In this review, we analyze the underlying mechanisms and describe the currently known differences between HLA-supported communication of implantation and that of tumors." @default.
- W2940171567 created "2019-04-25" @default.
- W2940171567 creator A5009966258 @default.
- W2940171567 creator A5014730886 @default.
- W2940171567 creator A5062012521 @default.
- W2940171567 creator A5063144740 @default.
- W2940171567 creator A5074503197 @default.
- W2940171567 date "2019-04-12" @default.
- W2940171567 modified "2023-10-14" @default.
- W2940171567 title "European Patent in Immunoncology: From Immunological Principles of Implantation to Cancer Treatment" @default.
- W2940171567 cites W1256976341 @default.
- W2940171567 cites W1483271435 @default.
- W2940171567 cites W1484816825 @default.
- W2940171567 cites W1491359326 @default.
- W2940171567 cites W1492184352 @default.
- W2940171567 cites W1492708996 @default.
- W2940171567 cites W1547335021 @default.
- W2940171567 cites W1564749019 @default.
- W2940171567 cites W1568276869 @default.
- W2940171567 cites W160271021 @default.
- W2940171567 cites W1605315426 @default.
- W2940171567 cites W1610940035 @default.
- W2940171567 cites W1640646570 @default.
- W2940171567 cites W1772741472 @default.
- W2940171567 cites W1775356736 @default.
- W2940171567 cites W1796884944 @default.
- W2940171567 cites W1813280497 @default.
- W2940171567 cites W1849122184 @default.
- W2940171567 cites W1859347062 @default.
- W2940171567 cites W1906987668 @default.
- W2940171567 cites W1964504259 @default.
- W2940171567 cites W1966051722 @default.
- W2940171567 cites W1966273058 @default.
- W2940171567 cites W1967035409 @default.
- W2940171567 cites W1967263426 @default.
- W2940171567 cites W1969998172 @default.
- W2940171567 cites W1970126045 @default.
- W2940171567 cites W1970410047 @default.
- W2940171567 cites W1970980105 @default.
- W2940171567 cites W1972258248 @default.
- W2940171567 cites W1973106184 @default.
- W2940171567 cites W1973193045 @default.
- W2940171567 cites W1974670739 @default.
- W2940171567 cites W1975944134 @default.
- W2940171567 cites W1976075738 @default.
- W2940171567 cites W1976696463 @default.
- W2940171567 cites W1976805459 @default.
- W2940171567 cites W1977176164 @default.
- W2940171567 cites W1979253523 @default.
- W2940171567 cites W1981158549 @default.
- W2940171567 cites W1981815217 @default.
- W2940171567 cites W1983064122 @default.
- W2940171567 cites W1983465178 @default.
- W2940171567 cites W1985043455 @default.
- W2940171567 cites W1985936000 @default.
- W2940171567 cites W1986672594 @default.
- W2940171567 cites W1987344928 @default.
- W2940171567 cites W1987722983 @default.
- W2940171567 cites W1988669960 @default.
- W2940171567 cites W1988833905 @default.
- W2940171567 cites W1990757073 @default.
- W2940171567 cites W1992800211 @default.
- W2940171567 cites W1994255893 @default.
- W2940171567 cites W1994667210 @default.
- W2940171567 cites W1997994653 @default.
- W2940171567 cites W1999664064 @default.
- W2940171567 cites W1999851129 @default.
- W2940171567 cites W2001228876 @default.
- W2940171567 cites W2002220805 @default.
- W2940171567 cites W2002914932 @default.
- W2940171567 cites W2003939651 @default.
- W2940171567 cites W2005291161 @default.
- W2940171567 cites W2005449334 @default.
- W2940171567 cites W2005561356 @default.
- W2940171567 cites W2005917926 @default.
- W2940171567 cites W2006286418 @default.
- W2940171567 cites W2007806512 @default.
- W2940171567 cites W2011674123 @default.
- W2940171567 cites W2015686032 @default.
- W2940171567 cites W2016249920 @default.
- W2940171567 cites W2016870461 @default.
- W2940171567 cites W2017824838 @default.
- W2940171567 cites W2020181553 @default.
- W2940171567 cites W2020512673 @default.
- W2940171567 cites W2020651991 @default.
- W2940171567 cites W2021902701 @default.
- W2940171567 cites W2024533943 @default.
- W2940171567 cites W2026459499 @default.
- W2940171567 cites W2026588672 @default.
- W2940171567 cites W2029175700 @default.
- W2940171567 cites W2029488286 @default.
- W2940171567 cites W2030307609 @default.
- W2940171567 cites W2031474460 @default.
- W2940171567 cites W2031509003 @default.
- W2940171567 cites W2031641946 @default.
- W2940171567 cites W2032233271 @default.
- W2940171567 cites W2035298228 @default.
- W2940171567 cites W2035774630 @default.