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• W2940196652 abstract "The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically reconfigures neocortical microcircuitry through differential spatiotemporal actions on cell-types and their synaptic connections. At the cellular level, ACh release controls neuronal excitability and firing rate, by hyperpolarizing or depolarizing target neurons. At the synaptic level, ACh impacts transmission dynamics not only by altering the presynaptic probability of release, but also the magnitude of the postsynaptic response. Despite the crucial role of ACh release in physiology and pathophysiology, a comprehensive understanding of the way it regulates the activity of diverse neocortical cell-types and synaptic connections has remained elusive. This review aims to summarize the state-of-the-art anatomical and physiological data to develop a functional map of the cellular, synaptic and microcircuit effects of ACh in the neocortex of rodents and non-human primates, and to serve as a quantitative reference for those intending to build data-driven computational models on the role of ACh in governing brain states." @default.
• W2940196652 created "2019-04-25" @default.
• W2940196652 creator A5031748394 @default.
• W2940196652 creator A5064154590 @default.
• W2940196652 creator A5069964239 @default.
• W2940196652 creator A5087651953 @default.
• W2940196652 creator A5091211777 @default.
• W2940196652 date "2019-04-12" @default.
• W2940196652 modified "2023-10-16" @default.
• W2940196652 title "Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex" @default.
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