FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940248001> ?p ?o ?g. }

• W2940248001 endingPage "7055" @default.
• W2940248001 startingPage "7045" @default.
• W2940248001 abstract "The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine D2 receptor (D2R)-sigma 1 receptor (δ1R) heteroreceptor complexes and the D2R protomer recognition, signaling and internalization in cellular models. We report the existence of D2R-δ1R heteroreceptor complexes in subcortical limbic areas as well as the dorsal striatum, with different distribution patterns using the in situ proximity ligation assay. Also, through BRET, these heteromers were demonstrated in HEK293 cells. Furthermore, saturation binding assay demonstrated that in membrane preparations of HEK293 cells coexpressing D2R and δ1R, cocaine (1 nM) significantly increased the D2R Bmax values over cells singly expressing D2R. CREB reporter luc-gene assay indicated that coexpressed δ1R significantly reduced the potency of the D2R-like agonist quinpirole to inhibit via D2R activation the forskolin induced increase of the CREB signal. In contrast, the addition of 100 nM cocaine was found to markedly increase the quinpirole potency to inhibit the forskolin-induced increase of the CREB signal in the D2R-δ1R cells. These events were associated with a marked reduction of cocaine-induced internalization of D2R protomers in D2R-δ1R heteromer-containing cells vs D2R singly expressing cells as studied by means of confocal analysis of D2R-δ1R trafficking and internalization. Overall, the formation of D2R-δ1R heteromers enhanced the ability of cocaine to increase the D2R protomer function associated with a marked reduction of its internalization. The existence of D2R-δ1R heteromers opens up a new understanding of the acute actions of cocaine." @default.
• W2940248001 created "2019-04-25" @default.
• W2940248001 creator A5011827905 @default.
• W2940248001 creator A5016373261 @default.
• W2940248001 creator A5017233022 @default.
• W2940248001 creator A5020373627 @default.
• W2940248001 creator A5034120148 @default.
• W2940248001 creator A5040729812 @default.
• W2940248001 creator A5049439898 @default.
• W2940248001 creator A5086684669 @default.
• W2940248001 creator A5089406761 @default.
• W2940248001 date "2019-04-10" @default.
• W2940248001 modified "2023-10-15" @default.
• W2940248001 title "Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes" @default.
• W2940248001 cites W1636386427 @default.
• W2940248001 cites W173323332 @default.
• W2940248001 cites W1913013241 @default.
• W2940248001 cites W1976084290 @default.
• W2940248001 cites W1986134784 @default.
• W2940248001 cites W1988973849 @default.
• W2940248001 cites W1995552213 @default.
• W2940248001 cites W2007143013 @default.
• W2940248001 cites W2009538078 @default.
• W2940248001 cites W2010054737 @default.
• W2940248001 cites W2020703932 @default.
• W2940248001 cites W2021399955 @default.
• W2940248001 cites W2034592530 @default.
• W2940248001 cites W2047453275 @default.
• W2940248001 cites W2064715357 @default.
• W2940248001 cites W2066346996 @default.
• W2940248001 cites W2069437503 @default.
• W2940248001 cites W2071287117 @default.
• W2940248001 cites W2072735845 @default.
• W2940248001 cites W2083097367 @default.
• W2940248001 cites W2088872562 @default.
• W2940248001 cites W2096688894 @default.
• W2940248001 cites W2102743964 @default.
• W2940248001 cites W2106588046 @default.
• W2940248001 cites W2497275630 @default.
• W2940248001 cites W2593204000 @default.
• W2940248001 cites W2755339915 @default.
• W2940248001 cites W2771316861 @default.
• W2940248001 doi "https://doi.org/10.1007/s12035-019-1580-8" @default.
• W2940248001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6728299" @default.
• W2940248001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30972626" @default.
• W2940248001 hasPublicationYear "2019" @default.
• W2940248001 type Work @default.
• W2940248001 sameAs 2940248001 @default.
• W2940248001 citedByCount "11" @default.
• W2940248001 countsByYear W29402480012019 @default.
• W2940248001 countsByYear W29402480012020 @default.
• W2940248001 countsByYear W29402480012021 @default.
• W2940248001 countsByYear W29402480012022 @default.
• W2940248001 crossrefType "journal-article" @default.
• W2940248001 hasAuthorship W2940248001A5011827905 @default.
• W2940248001 hasAuthorship W2940248001A5016373261 @default.
• W2940248001 hasAuthorship W2940248001A5017233022 @default.
• W2940248001 hasAuthorship W2940248001A5020373627 @default.
• W2940248001 hasAuthorship W2940248001A5034120148 @default.
• W2940248001 hasAuthorship W2940248001A5040729812 @default.
• W2940248001 hasAuthorship W2940248001A5049439898 @default.
• W2940248001 hasAuthorship W2940248001A5086684669 @default.
• W2940248001 hasAuthorship W2940248001A5089406761 @default.
• W2940248001 hasBestOaLocation W29402480011 @default.
• W2940248001 hasConcept C12554922 @default.
• W2940248001 hasConcept C137183658 @default.
• W2940248001 hasConcept C139770010 @default.
• W2940248001 hasConcept C169760540 @default.
• W2940248001 hasConcept C170493617 @default.
• W2940248001 hasConcept C185592680 @default.
• W2940248001 hasConcept C2776755682 @default.
• W2940248001 hasConcept C2778296116 @default.
• W2940248001 hasConcept C2778938600 @default.
• W2940248001 hasConcept C44208683 @default.
• W2940248001 hasConcept C513476851 @default.
• W2940248001 hasConcept C55493867 @default.
• W2940248001 hasConcept C86803240 @default.
• W2940248001 hasConcept C95444343 @default.
• W2940248001 hasConcept C98274493 @default.
• W2940248001 hasConceptScore W2940248001C12554922 @default.
• W2940248001 hasConceptScore W2940248001C137183658 @default.
• W2940248001 hasConceptScore W2940248001C139770010 @default.
• W2940248001 hasConceptScore W2940248001C169760540 @default.
• W2940248001 hasConceptScore W2940248001C170493617 @default.
• W2940248001 hasConceptScore W2940248001C185592680 @default.
• W2940248001 hasConceptScore W2940248001C2776755682 @default.
• W2940248001 hasConceptScore W2940248001C2778296116 @default.
• W2940248001 hasConceptScore W2940248001C2778938600 @default.
• W2940248001 hasConceptScore W2940248001C44208683 @default.
• W2940248001 hasConceptScore W2940248001C513476851 @default.
• W2940248001 hasConceptScore W2940248001C55493867 @default.
• W2940248001 hasConceptScore W2940248001C86803240 @default.
• W2940248001 hasConceptScore W2940248001C95444343 @default.
• W2940248001 hasConceptScore W2940248001C98274493 @default.
• W2940248001 hasIssue "10" @default.
• W2940248001 hasLocation W29402480011 @default.
• W2940248001 hasLocation W29402480012 @default.
• W2940248001 hasLocation W29402480013 @default.

• next