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- W2940248057 abstract "Protein segregation contributes to various cellular processes such as polarization, differentiation, and aging. However, the difficulty in global determination of protein segregation hampers our understanding of its mechanisms and physiological roles. Here, by developing a quantitative proteomics technique, we globally monitored segregation of preexisting and newly synthesized proteins during cell division of budding yeast, and identified crucial domains that determine the segregation of cell-peripheral proteins. Remarkably, the proteomic and subsequent microscopic analyses demonstrated that the flow through the bud neck of the proteins that harbor both endoplasmic reticulum (ER) membrane-spanning and plasma membrane (PM)-binding domains is not restricted by the previously suggested ER membrane or PM diffusion barriers but by septin-mediated partitioning of the PM-associated ER (pmaER). Furthermore, the proteomic analysis revealed that although the PM-spanning t-SNARE Sso2 was retained in mother cells, its paralog Sso1 unexpectedly showed symmetric localization. We found that the transport of Sso1 to buds was required for enhancement of polarized cell growth and resistance to cell-wall stress. Taken together, these data resolve long-standing questions about septin-mediated compartmentalization of the cell periphery, and provide new mechanistic insights into the segregation of cell-periphery proteins and their cellular functions." @default.
- W2940248057 created "2019-04-25" @default.
- W2940248057 creator A5053962676 @default.
- W2940248057 creator A5081069296 @default.
- W2940248057 date "2019-04-11" @default.
- W2940248057 modified "2023-09-23" @default.
- W2940248057 title "Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis" @default.
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- W2940248057 cites W1981840094 @default.
- W2940248057 cites W1982227685 @default.
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- W2940248057 doi "https://doi.org/10.1073/pnas.1819715116" @default.
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- W2940248057 hasPublicationYear "2019" @default.
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