Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940277772> ?p ?o ?g. }
- W2940277772 endingPage "2510" @default.
- W2940277772 startingPage "2502" @default.
- W2940277772 abstract "Intracellular doxorubicin (DOX) pumping out of cells through the P-glycoprotein (P-gp) transporter leads to the reduction of intracellular DOX levels and induces multidrug resistance (MDR). A hyaluronic acid–deoxycholic acid–histidine and Pluronic F127 (PF127) mixed micellar system, named HA-DOCA-His-PF micelles, functionalized with active targeted endocytosis mediated via CD44 receptor, intracellular triggered DOX release under endosome-pH, and combined with PF127-mediated P-gp efflux inhibition was developed for sufficient intracellular DOX delivery and MDR reversion. The DOX/HA-DOCA-His-PF drug-loaded micelles displayed endosomal pH-mediated self-assembly/disassembly characteristics, triggered DOX release under an endosomal (pH 5.5) environment, and demonstrated enhanced cytotoxicity and superior MDR reversion performance against drug-resistant MCF-7/Adr tumor cells. Importantly, superior antitumor activity of DOX/HA-DOCA-His-PF micelles was presented on the growth inhibition of MCF-7/Adr tumor cells, by further inhibiting the P-gp activity on intracellular DOX efflux through the depletion of intracellular adenosine triphosphate content. This multifunctional micellar system could be facilitated by the intracellular DOX delivery for reversing MDR of breast cancer." @default.
- W2940277772 created "2019-04-25" @default.
- W2940277772 creator A5000264291 @default.
- W2940277772 creator A5007014544 @default.
- W2940277772 creator A5036867860 @default.
- W2940277772 creator A5054685059 @default.
- W2940277772 creator A5061927010 @default.
- W2940277772 creator A5078944760 @default.
- W2940277772 creator A5082111724 @default.
- W2940277772 creator A5091398589 @default.
- W2940277772 date "2019-04-18" @default.
- W2940277772 modified "2023-10-01" @default.
- W2940277772 title "Multifunctionalized Micelles Facilitate Intracellular Doxorubicin Delivery for Reversing Multidrug Resistance of Breast Cancer" @default.
- W2940277772 cites W1528820340 @default.
- W2940277772 cites W1935717104 @default.
- W2940277772 cites W1965910946 @default.
- W2940277772 cites W1984677400 @default.
- W2940277772 cites W1994941022 @default.
- W2940277772 cites W1998804638 @default.
- W2940277772 cites W2013224924 @default.
- W2940277772 cites W2017052864 @default.
- W2940277772 cites W2029071448 @default.
- W2940277772 cites W2038626534 @default.
- W2940277772 cites W2048912984 @default.
- W2940277772 cites W2054757669 @default.
- W2940277772 cites W2055904567 @default.
- W2940277772 cites W2069360982 @default.
- W2940277772 cites W2084016080 @default.
- W2940277772 cites W2086374939 @default.
- W2940277772 cites W2093066634 @default.
- W2940277772 cites W2099797949 @default.
- W2940277772 cites W2103039714 @default.
- W2940277772 cites W2134709133 @default.
- W2940277772 cites W2139107535 @default.
- W2940277772 cites W2140667096 @default.
- W2940277772 cites W2141326699 @default.
- W2940277772 cites W2142259199 @default.
- W2940277772 cites W2149064045 @default.
- W2940277772 cites W2169302611 @default.
- W2940277772 cites W2169829820 @default.
- W2940277772 cites W2324073933 @default.
- W2940277772 cites W2328605846 @default.
- W2940277772 cites W2409603104 @default.
- W2940277772 cites W2474432557 @default.
- W2940277772 cites W2544908095 @default.
- W2940277772 cites W2584318012 @default.
- W2940277772 cites W2605243727 @default.
- W2940277772 cites W2760892858 @default.
- W2940277772 cites W2762191546 @default.
- W2940277772 cites W2771640079 @default.
- W2940277772 cites W2781426298 @default.
- W2940277772 cites W2802117869 @default.
- W2940277772 cites W2809118171 @default.
- W2940277772 cites W2898086063 @default.
- W2940277772 cites W53566393 @default.
- W2940277772 doi "https://doi.org/10.1021/acs.molpharmaceut.9b00094" @default.
- W2940277772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30998372" @default.
- W2940277772 hasPublicationYear "2019" @default.
- W2940277772 type Work @default.
- W2940277772 sameAs 2940277772 @default.
- W2940277772 citedByCount "25" @default.
- W2940277772 countsByYear W29402777722019 @default.
- W2940277772 countsByYear W29402777722020 @default.
- W2940277772 countsByYear W29402777722021 @default.
- W2940277772 countsByYear W29402777722022 @default.
- W2940277772 countsByYear W29402777722023 @default.
- W2940277772 crossrefType "journal-article" @default.
- W2940277772 hasAuthorship W2940277772A5000264291 @default.
- W2940277772 hasAuthorship W2940277772A5007014544 @default.
- W2940277772 hasAuthorship W2940277772A5036867860 @default.
- W2940277772 hasAuthorship W2940277772A5054685059 @default.
- W2940277772 hasAuthorship W2940277772A5061927010 @default.
- W2940277772 hasAuthorship W2940277772A5078944760 @default.
- W2940277772 hasAuthorship W2940277772A5082111724 @default.
- W2940277772 hasAuthorship W2940277772A5091398589 @default.
- W2940277772 hasConcept C109316439 @default.
- W2940277772 hasConcept C11268172 @default.
- W2940277772 hasConcept C121608353 @default.
- W2940277772 hasConcept C126322002 @default.
- W2940277772 hasConcept C133936738 @default.
- W2940277772 hasConcept C147789679 @default.
- W2940277772 hasConcept C170493617 @default.
- W2940277772 hasConcept C184651966 @default.
- W2940277772 hasConcept C185592680 @default.
- W2940277772 hasConcept C200082930 @default.
- W2940277772 hasConcept C202751555 @default.
- W2940277772 hasConcept C2776694085 @default.
- W2940277772 hasConcept C2778707650 @default.
- W2940277772 hasConcept C2781303535 @default.
- W2940277772 hasConcept C28005876 @default.
- W2940277772 hasConcept C501593827 @default.
- W2940277772 hasConcept C55493867 @default.
- W2940277772 hasConcept C71924100 @default.
- W2940277772 hasConcept C79879829 @default.
- W2940277772 hasConcept C96232424 @default.
- W2940277772 hasConcept C98274493 @default.
- W2940277772 hasConceptScore W2940277772C109316439 @default.
- W2940277772 hasConceptScore W2940277772C11268172 @default.