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- W2940282952 endingPage "349" @default.
- W2940282952 startingPage "325" @default.
- W2940282952 abstract "Abstract Adenylate-forming enzymes are a mechanistic superfamily that are involved in diverse biochemical pathways. They catalyze ATP-dependent activation of carboxylic acid substrates as reactive acyl adenylate (acyl-AMP) intermediates and subsequent coupling to various nucleophiles to generate ester, thioester, and amide products. Inspired by natural products, acyl sulfonyladenosines (acyl-AMS) that mimic the tightly bound acyl-AMP reaction intermediates have been developed as potent inhibitors of adenylate-forming enzymes. This simple yet powerful inhibitor design platform has provided a wide range of biological probes as well as several therapeutic lead compounds. Herein, we provide an overview of the nine structural classes of adenylate-forming enzymes and examples of acyl-AMS inhibitors that have been developed for each." @default.
- W2940282952 created "2019-04-25" @default.
- W2940282952 creator A5002081695 @default.
- W2940282952 creator A5019849531 @default.
- W2940282952 creator A5079458342 @default.
- W2940282952 date "2019-04-15" @default.
- W2940282952 modified "2023-10-14" @default.
- W2940282952 title "Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors" @default.
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