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- W2940289922 abstract "Penicillin and related antibiotics disrupt cell wall synthesis to induce bacteriolysis. Lysis in response to these drugs requires the activity of cell wall hydrolases called autolysins, but how penicillins misactivate these deadly enzymes has long remained unclear. Here, we show that alterations in surface polymers called teichoic acids (TAs) play a key role in penicillin-induced lysis of the Gram-positive pathogen Streptococcus pneumoniae (Sp). We find that during exponential growth, Sp cells primarily produce lipid-anchored TAs called lipoteichoic acids (LTAs) that bind and sequester the major autolysin LytA. However, penicillin-treatment or prolonged stationary phase growth triggers the degradation of a key LTA synthase, causing a switch to the production of wall-anchored TAs (WTAs). This change allows LytA to associate with and degrade its cell wall substrate, thus promoting osmotic lysis. Similar changes in surface polymer assembly may underlie the mechanism of antibiotic- and/or growth phase-induced lysis for other important Gram-positive pathogens." @default.
- W2940289922 created "2019-04-25" @default.
- W2940289922 creator A5011205200 @default.
- W2940289922 creator A5020259443 @default.
- W2940289922 creator A5060030884 @default.
- W2940289922 creator A5065212721 @default.
- W2940289922 creator A5070340434 @default.
- W2940289922 date "2019-04-09" @default.
- W2940289922 modified "2023-10-16" @default.
- W2940289922 title "A switch in surface polymer biogenesis triggers growth-phase-dependent and antibiotic-induced bacteriolysis" @default.
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- W2940289922 doi "https://doi.org/10.7554/elife.44912" @default.
- W2940289922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6456293" @default.
- W2940289922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30964003" @default.
- W2940289922 hasPublicationYear "2019" @default.
- W2940289922 type Work @default.
- W2940289922 sameAs 2940289922 @default.