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• W2940332562 endingPage "e0215009" @default.
• W2940332562 startingPage "e0215009" @default.
• W2940332562 abstract "Interorganelle phospholipid transfer is critical for eukaryotic membrane biogenesis. In the yeast Saccharomyces cerevisiae, phosphatidylserine (PS) synthesized by PS synthase, Pss1, in the endoplasmic reticulum (ER) is decarboxylated to phosphatidylethanolamine (PE) by PS decarboxylase, Psd1, in the ER and mitochondria or by Psd2 in the endosome, Golgi, and/or vacuole, but the mechanism of interorganelle PS transport remains to be elucidated. Here we report that Sfh1, a member of Sec14 family proteins of S. cerevisiae, possesses the ability to enhance PE production by Psd2. Overexpression of SFH1 in the strain defective in Psd1 restored its growth on non-fermentable carbon sources and increased the intracellular and mitochondrial PE levels. Sfh1 was found to bind various phospholipids, including PS, in vivo. Bacterially expressed and purified Sfh1 was suggested to have the ability to transport fluorescently labeled PS between liposomes by fluorescence dequenching assay in vitro. Biochemical subcellular fractionation suggested that a fraction of Sfh1 localizes to the endosome, Golgi, and/or vacuole. We propose a model that Sfh1 promotes PE production by Psd2 by transferring phospholipids between the ER and endosome." @default.
• W2940332562 created "2019-04-25" @default.
• W2940332562 creator A5004353089 @default.
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• W2940332562 creator A5078970228 @default.
• W2940332562 creator A5083700886 @default.
• W2940332562 date "2019-04-08" @default.
• W2940332562 modified "2023-10-03" @default.
• W2940332562 title "Suppression of respiratory growth defect of mitochondrial phosphatidylserine decarboxylase deficient mutant by overproduction of Sfh1, a Sec14 homolog, in yeast" @default.
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• W2940332562 doi "https://doi.org/10.1371/journal.pone.0215009" @default.
• W2940332562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6453485" @default.
• W2940332562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30958856" @default.
• W2940332562 hasPublicationYear "2019" @default.
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