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• W2940334895 abstract "Enzymatic blood glucose detection with selectivity is one of the most important conundrums, because human blood contains many components that can hinder enzyme-substrate reactions. Meanwhile, cancer cells express much higher levels of glucose transporter-1 on their cell membrane to selectively and excessively uptake more α-D-glucose than do normal cells. Inspired by such cellular permselectivity for glucose, herein we significantly improved the selectivity of a glucose sensor by using a breast cancer cell membrane (BCCM). The BCCM was extracted from MDA-MB-231 cells and coated onto an enzyme-deposited electrode via a vesicle fusion method. We investigated BCCM-coated sensors using ATR-FTIR, SEM, AFM, and cyclic voltammetry. The exceptional permselectivity of BCCM-coated sensors was validated using glucose solutions containing various interfering molecules (e.g., D-(-)-fructose, D-(+)-xylose, D-(+)-maltose, L-cysteine, L-ascorbic acid, and uric acid) and human serum (4.35-7.35 mM of glucose), implying their high potential for practical use." @default.
• W2940334895 created "2019-04-25" @default.
• W2940334895 creator A5023579289 @default.
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• W2940334895 date "2019-06-01" @default.
• W2940334895 modified "2023-10-17" @default.
• W2940334895 title "Permselective glucose sensing with GLUT1-rich cancer cell membranes" @default.
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• W2940334895 doi "https://doi.org/10.1016/j.bios.2019.04.007" @default.
• W2940334895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31004924" @default.
• W2940334895 hasPublicationYear "2019" @default.
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