FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940348580> ?p ?o ?g. }

• W2940348580 abstract "Abstract Adults with childhood-onset attention-deficit hyperactivity disorder (ADHD) show altered whole-brain connectivity. However, the relationship between structural and functional brain abnormalities, the implications for the development of life-long debilitating symptoms, and the underlying mechanisms remain uncharted. We recruited a unique sample of 80 medication-naive adults with a clinical diagnosis of childhood-onset ADHD without psychiatric comorbidities, and 123 age-, sex-, and intelligence-matched healthy controls. Structural and functional connectivity matrices were derived from diffusion spectrum imaging and multi-echo resting-state functional MRI data. Hub, feeder, and local connections were defined using diffusion data. Individual-level measures of structural connectivity and structure-function coupling were used to contrast groups and link behavior to brain abnormalities. Computational modeling was used to test possible neural mechanisms underpinning observed group differences in the structure-function coupling. Structural connectivity did not significantly differ between groups but, relative to controls, ADHD showed a reduction in structure-function coupling in feeder connections linking hubs with peripheral regions. This abnormality involved connections linking fronto-parietal control systems with sensory networks. Crucially, lower structure-function coupling was associated with higher ADHD symptoms. Results from our computational model further suggest that the observed structure-function decoupling in ADHD is driven by heterogeneity in neural noise variability across brain regions. By highlighting a neural cause of a clinically meaningful breakdown in the structure-function relationship, our work provides novel information on the nature of chronic ADHD. The current results encourage future work assessing the genetic and neurobiological underpinnings of neural noise in ADHD, particularly in brain regions encompassed by fronto-parietal systems." @default.
• W2940348580 created "2019-04-25" @default.
• W2940348580 creator A5006126339 @default.
• W2940348580 creator A5007833663 @default.
• W2940348580 creator A5069235025 @default.
• W2940348580 creator A5076995446 @default.
• W2940348580 creator A5082531068 @default.
• W2940348580 creator A5082737012 @default.
• W2940348580 creator A5087358491 @default.
• W2940348580 date "2019-04-11" @default.
• W2940348580 modified "2023-09-25" @default.
• W2940348580 title "ADHD symptoms map onto noise-driven structure-function decoupling between hub and peripheral brain regions" @default.
• W2940348580 cites W1155786771 @default.
• W2940348580 cites W1823399016 @default.
• W2940348580 cites W1864161620 @default.
• W2940348580 cites W1965325756 @default.
• W2940348580 cites W1965559966 @default.
• W2940348580 cites W1968187292 @default.
• W2940348580 cites W1974660211 @default.
• W2940348580 cites W1980527160 @default.
• W2940348580 cites W1981176642 @default.
• W2940348580 cites W1983208632 @default.
• W2940348580 cites W1989432790 @default.
• W2940348580 cites W1990574575 @default.
• W2940348580 cites W1998679999 @default.
• W2940348580 cites W1999890357 @default.
• W2940348580 cites W2000619457 @default.
• W2940348580 cites W2006312249 @default.
• W2940348580 cites W2017588448 @default.
• W2940348580 cites W2025431637 @default.
• W2940348580 cites W2029386843 @default.
• W2940348580 cites W2033078279 @default.
• W2940348580 cites W2035055337 @default.
• W2940348580 cites W2040688164 @default.
• W2940348580 cites W2051900852 @default.
• W2940348580 cites W2053465090 @default.
• W2940348580 cites W2064598115 @default.
• W2940348580 cites W2068855396 @default.
• W2940348580 cites W2072379803 @default.
• W2940348580 cites W2079447427 @default.
• W2940348580 cites W2085409404 @default.
• W2940348580 cites W2085468620 @default.
• W2940348580 cites W2085561705 @default.
• W2940348580 cites W2090305817 @default.
• W2940348580 cites W2090495290 @default.
• W2940348580 cites W2091646494 @default.
• W2940348580 cites W2099355488 @default.
• W2940348580 cites W2106437517 @default.
• W2940348580 cites W2106592748 @default.
• W2940348580 cites W2112249501 @default.
• W2940348580 cites W2114186661 @default.
• W2940348580 cites W2117663940 @default.
• W2940348580 cites W2126838454 @default.
• W2940348580 cites W2127186958 @default.
• W2940348580 cites W2131181615 @default.
• W2940348580 cites W2131215403 @default.
• W2940348580 cites W2131807573 @default.
• W2940348580 cites W2132881605 @default.
• W2940348580 cites W2133323742 @default.
• W2940348580 cites W2135176690 @default.
• W2940348580 cites W2136697574 @default.
• W2940348580 cites W2142237276 @default.
• W2940348580 cites W2147033404 @default.
• W2940348580 cites W2151770129 @default.
• W2940348580 cites W2159929956 @default.
• W2940348580 cites W2160519427 @default.
• W2940348580 cites W2161493176 @default.
• W2940348580 cites W2162551380 @default.
• W2940348580 cites W2162753002 @default.
• W2940348580 cites W2167822639 @default.
• W2940348580 cites W2168497148 @default.
• W2940348580 cites W2209795071 @default.
• W2940348580 cites W2266642035 @default.
• W2940348580 cites W2267569572 @default.
• W2940348580 cites W2298354499 @default.
• W2940348580 cites W2336331068 @default.
• W2940348580 cites W2347548955 @default.
• W2940348580 cites W2402346616 @default.
• W2940348580 cites W2467410077 @default.
• W2940348580 cites W2491018836 @default.
• W2940348580 cites W2509443217 @default.
• W2940348580 cites W2515501400 @default.
• W2940348580 cites W2518506931 @default.
• W2940348580 cites W2519704068 @default.
• W2940348580 cites W2591872302 @default.
• W2940348580 cites W2604397136 @default.
• W2940348580 cites W2607276654 @default.
• W2940348580 cites W2733624013 @default.
• W2940348580 cites W2751335945 @default.
• W2940348580 cites W2754951831 @default.
• W2940348580 cites W2794047891 @default.
• W2940348580 cites W2794227021 @default.
• W2940348580 cites W2800118221 @default.
• W2940348580 cites W2802815532 @default.
• W2940348580 cites W2883986152 @default.
• W2940348580 cites W2890735443 @default.
• W2940348580 cites W2915428382 @default.
• W2940348580 cites W2951617899 @default.
• W2940348580 cites W2952083196 @default.
• W2940348580 cites W2952175763 @default.

• next