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- W2940366346 abstract "Sindbis virus (SINV) is an enveloped, single-stranded RNA virus, which is transmitted via mosquitos to a wide range of vertebrate hosts. SINV produced by vertebrate, baby hamster kidney (BHK) cells is more than an order of magnitude less infectious than SINV produced from mosquito (C6/36) cells. The cause of this difference is poorly understood. In this study, charge detection mass spectrometry was used to determine the masses of intact SINV particles isolated from BHK and C6/36 cells. The measured masses are substantially different: 52.88 MDa for BHK derived SINV and 50.69 MDa for C6/36 derived. Further analysis using several mass spectrometry-based methods and biophysical approaches indicates that BHK derived SINV has a substantially higher mass than C6/36 derived because in the lipid bilayer, there is a higher portion of lipids containing long chain fatty acids. The difference in lipid composition could influence the organization of the lipid bilayer. As a result, multiple stages of the viral lifecycle may be affected including assembly and budding, particle stability during transmission, and fusion events, all of which could contribute to the differences in infectivity." @default.
- W2940366346 created "2019-04-25" @default.
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- W2940366346 date "2019-04-15" @default.
- W2940366346 modified "2023-09-26" @default.
- W2940366346 title "Dissecting the Components of Sindbis Virus from Arthropod and Vertebrate Hosts: Implications for Infectivity Differences" @default.
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- W2940366346 doi "https://doi.org/10.1021/acsinfecdis.8b00356" @default.
- W2940366346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6570550" @default.
- W2940366346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30986033" @default.
- W2940366346 hasPublicationYear "2019" @default.
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