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- W2940367076 endingPage "387" @default.
- W2940367076 startingPage "363" @default.
- W2940367076 abstract "Halogenated organic compounds are pervasive in natural and built environments. Despite restrictions on the production of many of these compounds in most parts of the world through the Stockholm Convention on Persistent Organic Pollutants (POPs), many legacy compounds, including polychlorinated biphenyls (PCBs), are routinely detected in human tissues where they continue to pose significant health risks to highly exposed and susceptible populations. A major concern is developmental neurotoxicity, although impacts on neurodegenerative outcomes have also been noted. Here, we review human studies of prenatal and adult exposures to PCBs and describe the state of knowledge regarding outcomes across domains related to cognition (e.g., IQ, language, memory, learning), attention, behavioral regulation and executive function, and social behavior, including traits related to attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). We also review current understanding of molecular mechanisms underpinning these associations, with a focus on dopaminergic neurotransmission, thyroid hormone disruption, calcium dyshomeostasis, and oxidative stress. Finally, we briefly consider contemporary sources of organohalogens that may pose human health risks via mechanisms of neurotoxicity common to those ascribed to PCBs." @default.
- W2940367076 created "2019-04-25" @default.
- W2940367076 creator A5019478535 @default.
- W2940367076 creator A5062413385 @default.
- W2940367076 creator A5070218402 @default.
- W2940367076 creator A5079107220 @default.
- W2940367076 date "2019-04-11" @default.
- W2940367076 modified "2023-10-17" @default.
- W2940367076 title "Neurotoxicity of polychlorinated biphenyls and related organohalogens" @default.
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