Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940378044> ?p ?o ?g. }
- W2940378044 endingPage "1225" @default.
- W2940378044 startingPage "1214" @default.
- W2940378044 abstract "Most cases of hepatocellular carcinoma (HCC) are already advanced at the time of diagnosis, which limits treatment options. Challenges in early‐stage diagnosis may be due to the genetic complexity of HCC. Gene fusion plays a critical function in tumorigenesis and cancer progression in multiple cancers, yet the identities of fusion genes as potential diagnostic markers in HCC have not been investigated. Here, we employed STAR‐Fusion and identified 43 recurrent fusion events in our own and four public RNA‐seq datasets. We identified 2354 different gene fusions in two hepatitis B virus (HBV)‐HCC patients. Validation analysis against the four RNA‐seq datasets revealed that only 1.8% (43/2354) were recurrent fusions. Comparison with the four fusion databases demonstrated that 19 recurrent fusions were not previously annotated to diseases and three were annotated as disease‐related fusion events. Finally, we validated six of the novel fusion events, including RP11‐476K15.1‐CTD‐2015H3.2, by RT‐PCR and Sanger sequencing of 14 pairs of HBV‐related HCC samples. In summary, our study provides new insights into gene fusions in HCC and may contribute to the development of anti‐HCC therapy." @default.
- W2940378044 created "2019-04-25" @default.
- W2940378044 creator A5003222426 @default.
- W2940378044 creator A5008708317 @default.
- W2940378044 creator A5019943169 @default.
- W2940378044 creator A5023246860 @default.
- W2940378044 creator A5025798258 @default.
- W2940378044 creator A5041621533 @default.
- W2940378044 creator A5054150007 @default.
- W2940378044 creator A5057130892 @default.
- W2940378044 creator A5058611495 @default.
- W2940378044 creator A5059914435 @default.
- W2940378044 creator A5076863688 @default.
- W2940378044 creator A5084258079 @default.
- W2940378044 date "2019-04-11" @default.
- W2940378044 modified "2023-10-03" @default.
- W2940378044 title "The fusion landscape of hepatocellular carcinoma" @default.
- W2940378044 cites W1770922878 @default.
- W2940378044 cites W1810761522 @default.
- W2940378044 cites W1863396492 @default.
- W2940378044 cites W1892595029 @default.
- W2940378044 cites W1974489853 @default.
- W2940378044 cites W1974903221 @default.
- W2940378044 cites W2007601283 @default.
- W2940378044 cites W2021093893 @default.
- W2940378044 cites W2021650013 @default.
- W2940378044 cites W2027059718 @default.
- W2940378044 cites W2042337609 @default.
- W2940378044 cites W2053343049 @default.
- W2940378044 cites W2054524196 @default.
- W2940378044 cites W2055402151 @default.
- W2940378044 cites W2059866086 @default.
- W2940378044 cites W2065649212 @default.
- W2940378044 cites W2080277009 @default.
- W2940378044 cites W2082534286 @default.
- W2940378044 cites W2083568958 @default.
- W2940378044 cites W2092605924 @default.
- W2940378044 cites W2120723555 @default.
- W2940378044 cites W2122855404 @default.
- W2940378044 cites W2135530657 @default.
- W2940378044 cites W2139399606 @default.
- W2940378044 cites W2144134250 @default.
- W2940378044 cites W2144539352 @default.
- W2940378044 cites W2148064549 @default.
- W2940378044 cites W2150575159 @default.
- W2940378044 cites W2150945549 @default.
- W2940378044 cites W2151660860 @default.
- W2940378044 cites W2156145496 @default.
- W2940378044 cites W2161099760 @default.
- W2940378044 cites W2167237000 @default.
- W2940378044 cites W2167998323 @default.
- W2940378044 cites W2169456326 @default.
- W2940378044 cites W2271526763 @default.
- W2940378044 cites W2286057510 @default.
- W2940378044 cites W2293799788 @default.
- W2940378044 cites W2318224129 @default.
- W2940378044 cites W2332406512 @default.
- W2940378044 cites W2440007176 @default.
- W2940378044 cites W2557863110 @default.
- W2940378044 cites W2559182609 @default.
- W2940378044 cites W2607938959 @default.
- W2940378044 cites W2734763341 @default.
- W2940378044 cites W2810560383 @default.
- W2940378044 cites W2992837203 @default.
- W2940378044 doi "https://doi.org/10.1002/1878-0261.12479" @default.
- W2940378044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6487730" @default.
- W2940378044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30903738" @default.
- W2940378044 hasPublicationYear "2019" @default.
- W2940378044 type Work @default.
- W2940378044 sameAs 2940378044 @default.
- W2940378044 citedByCount "9" @default.
- W2940378044 countsByYear W29403780442019 @default.
- W2940378044 countsByYear W29403780442020 @default.
- W2940378044 countsByYear W29403780442021 @default.
- W2940378044 countsByYear W29403780442022 @default.
- W2940378044 crossrefType "journal-article" @default.
- W2940378044 hasAuthorship W2940378044A5003222426 @default.
- W2940378044 hasAuthorship W2940378044A5008708317 @default.
- W2940378044 hasAuthorship W2940378044A5019943169 @default.
- W2940378044 hasAuthorship W2940378044A5023246860 @default.
- W2940378044 hasAuthorship W2940378044A5025798258 @default.
- W2940378044 hasAuthorship W2940378044A5041621533 @default.
- W2940378044 hasAuthorship W2940378044A5054150007 @default.
- W2940378044 hasAuthorship W2940378044A5057130892 @default.
- W2940378044 hasAuthorship W2940378044A5058611495 @default.
- W2940378044 hasAuthorship W2940378044A5059914435 @default.
- W2940378044 hasAuthorship W2940378044A5076863688 @default.
- W2940378044 hasAuthorship W2940378044A5084258079 @default.
- W2940378044 hasBestOaLocation W29403780441 @default.
- W2940378044 hasConcept C104317684 @default.
- W2940378044 hasConcept C111829193 @default.
- W2940378044 hasConcept C159047783 @default.
- W2940378044 hasConcept C2522874641 @default.
- W2940378044 hasConcept C2777546739 @default.
- W2940378044 hasConcept C2778019345 @default.
- W2940378044 hasConcept C2780593183 @default.
- W2940378044 hasConcept C502942594 @default.
- W2940378044 hasConcept C51679486 @default.