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- W2940389907 abstract "Telomeres cap and protect DNA but shorten with each somatic cell division. Aging and environmental and lifestyle factors contribute to the speed of telomere attrition. Current evidence suggests a link between relative telomere length (RTL) and depression but the directionality of the relationship remains unclear. We prospectively examined associations between RTL and subsequent depressive symptom trajectories.Among 8,801 women of the Nurses' Health Study, depressive symptoms were measured every 4 years from 1992 to 2012; group-based trajectories of symptoms were identified using latent class growth-curve analysis. Multinomial logistic models were used to relate midlife RTLs to the probabilities of assignment to subsequent depressive symptom trajectory groups.We identified four depressive symptom trajectory groups: minimal depressive symptoms (62%), worsening depressive symptoms (14%), improving depressive symptoms (19%), and persistent-severe depressive symptoms (5%). Longer midlife RTLs were related to significantly lower odds of being in the worsening symptoms trajectory versus minimal trajectory but not to other trajectories. In comparison with being in the minimal symptoms group, the multivariable-adjusted odds ratio of being in the worsening depressive symptoms group was 0.78 (95% confidence interval, 0.62-0.97; p = 0.02), for every standard deviation increase in baseline RTL.In this large prospective study of generally healthy women, longer telomeres at midlife were associated with significantly lower risk of a subsequent trajectory of worsening mood symptoms over 20 years. The results raise the possibility of telomere shortening as a novel contributing factor to late-life depression." @default.
- W2940389907 created "2019-04-25" @default.
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- W2940389907 date "2019-04-08" @default.
- W2940389907 modified "2023-10-14" @default.
- W2940389907 title "The relation of telomere length at midlife to subsequent 20‐year depression trajectories among women" @default.
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- W2940389907 cites W1844054685 @default.
- W2940389907 cites W1951670987 @default.
- W2940389907 cites W1957468587 @default.
- W2940389907 cites W1965364326 @default.
- W2940389907 cites W1973683611 @default.
- W2940389907 cites W1975418095 @default.
- W2940389907 cites W1981590577 @default.
- W2940389907 cites W1988354925 @default.
- W2940389907 cites W1990151307 @default.
- W2940389907 cites W1993219114 @default.
- W2940389907 cites W1998150842 @default.
- W2940389907 cites W2000445173 @default.
- W2940389907 cites W2003171243 @default.
- W2940389907 cites W2013071495 @default.
- W2940389907 cites W2013379214 @default.
- W2940389907 cites W2015784740 @default.
- W2940389907 cites W2019063243 @default.
- W2940389907 cites W2029046909 @default.
- W2940389907 cites W2030803494 @default.
- W2940389907 cites W2032358622 @default.
- W2940389907 cites W2037377025 @default.
- W2940389907 cites W2039354765 @default.
- W2940389907 cites W2042513845 @default.
- W2940389907 cites W2045571168 @default.
- W2940389907 cites W2048279184 @default.
- W2940389907 cites W2049909326 @default.
- W2940389907 cites W2057065562 @default.
- W2940389907 cites W2058351711 @default.
- W2940389907 cites W2062172666 @default.
- W2940389907 cites W2063043748 @default.
- W2940389907 cites W2064127648 @default.
- W2940389907 cites W2065609136 @default.
- W2940389907 cites W2066134491 @default.
- W2940389907 cites W2068211792 @default.
- W2940389907 cites W2086521405 @default.
- W2940389907 cites W2100286062 @default.
- W2940389907 cites W2111096670 @default.
- W2940389907 cites W2112126701 @default.
- W2940389907 cites W2116264741 @default.
- W2940389907 cites W2120032880 @default.
- W2940389907 cites W2120423982 @default.
- W2940389907 cites W2120826795 @default.
- W2940389907 cites W2122025671 @default.
- W2940389907 cites W2124098526 @default.
- W2940389907 cites W2127065258 @default.
- W2940389907 cites W2132387055 @default.
- W2940389907 cites W2133466547 @default.
- W2940389907 cites W2137448406 @default.
- W2940389907 cites W2146485405 @default.
- W2940389907 cites W2153216542 @default.
- W2940389907 cites W2155828273 @default.
- W2940389907 cites W2156714633 @default.
- W2940389907 cites W2167637169 @default.
- W2940389907 cites W2180733301 @default.
- W2940389907 cites W2188949284 @default.
- W2940389907 cites W2262945889 @default.
- W2940389907 cites W2289624033 @default.
- W2940389907 cites W2473749386 @default.
- W2940389907 cites W2498769993 @default.
- W2940389907 cites W2545052656 @default.
- W2940389907 cites W2601429811 @default.
- W2940389907 cites W2607361070 @default.
- W2940389907 cites W2625406564 @default.
- W2940389907 cites W2768375420 @default.
- W2940389907 cites W2790575937 @default.
- W2940389907 cites W2791035563 @default.
- W2940389907 cites W4292806894 @default.
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- W2940389907 doi "https://doi.org/10.1002/da.22892" @default.
- W2940389907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6548605" @default.
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- W2940389907 hasPublicationYear "2019" @default.
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