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• W2940420917 endingPage "146" @default.
• W2940420917 startingPage "136" @default.
• W2940420917 abstract "The central melanocortin system is composed of neurons that express either the proopiomelanocortin (POMC) or the agouti-related protein (AgRP). POMC is cleaved in bioactive peptides, including the α-melanocyte-stimulating hormone (α-MSH). α-MSH activates the melanocortin-4 receptor (MC4R) inducing satiety, whereas AgRP acts as an inverse agonist of MC4R. However, only limited information is available regarding possible area-specific differences in the interaction between α-MSH and AgRP terminals on MC4R-expressing cells. Therefore, the objective of the present study was to compare the distribution pattern of α-MSH and AgRP terminals on the perikarya of MC4R-expressing neurons. We performed a triple-label immunofluorescence reaction in brain series of MC4R-reporter mice to visualize MC4R-expressing neurons together with AgRP and α-MSH terminals. POMC and AgRP neurons project to areas that contain MC4R-expressing cells, although several brain nuclei exhibit AgRP and α-MSH terminals, but they do no express MC4R, while other brain areas contain MC4R-expressing cells and receive no apparent innervation of AgRP and POMC neurons. AgRP terminals make more presumptive appositions than α-MSH on the soma of MC4R-expressing neurons of the medial preoptic area and paraventricular nucleus of the hypothalamus (Pa). Additionally, a higher percentage of MC4R cells receive at least one presumptive apposition from AgRP terminals in the median preoptic nucleus and Pa, compared to α-MSH appositions. Thus, our study revealed area-specific differences in the interaction between α-MSH and AgRP terminals and the soma of MC4R-expressing neurons. These findings provide new insights about the relationship between first- and second-order neurons of the central melanocortin system." @default.
• W2940420917 created "2019-04-25" @default.
• W2940420917 creator A5032897514 @default.
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• W2940420917 date "2019-08-01" @default.
• W2940420917 modified "2023-10-18" @default.
• W2940420917 title "Relationship of α-MSH and AgRP axons to the perikarya of melanocortin-4 receptor neurons" @default.
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• W2940420917 doi "https://doi.org/10.1016/j.brainres.2019.04.021" @default.
• W2940420917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31009611" @default.
• W2940420917 hasPublicationYear "2019" @default.
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