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- W2940429062 abstract "The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms against exogenous or endogenous stressors. Indeed, by increasing the expression of several cytoprotective genes, the transcription factor NRF2 can shelter cells and tissues from multiple sources of damage including xenobiotic, electrophilic, metabolic, and oxidative stress. Importantly, the aberrant activation or accumulation of NRF2, a common event in many tumors, confers a selective advantage to cancer cells and is associated to malignant progression, therapy resistance, and poor prognosis. Hence, in the last years, NRF2 has emerged as a promising target in cancer treatment and many efforts have been made to identify therapeutic strategies aimed at disrupting its prooncogenic role. By summarizing the results from past and recent studies, in this review, we provide an overview concerning the NRF2/KEAP1 pathway, its biological impact in solid and hematologic malignancies, and the molecular mechanisms causing NRF2 hyperactivation in cancer cells. Finally, we also describe some of the most promising therapeutic approaches that have been successfully employed to counteract NRF2 activity in tumors, with a particular emphasis on the development of natural compounds and the adoption of drug repurposing strategies." @default.
- W2940429062 created "2019-04-25" @default.
- W2940429062 creator A5058162514 @default.
- W2940429062 creator A5065222117 @default.
- W2940429062 date "2019-04-11" @default.
- W2940429062 modified "2023-10-14" @default.
- W2940429062 title "Potential Applications of NRF2 Inhibitors in Cancer Therapy" @default.
- W2940429062 cites W1231316025 @default.
- W2940429062 cites W1421415727 @default.
- W2940429062 cites W144423133 @default.
- W2940429062 cites W1490002361 @default.
- W2940429062 cites W1498098115 @default.
- W2940429062 cites W1517497707 @default.
- W2940429062 cites W1522860394 @default.
- W2940429062 cites W1523693806 @default.
- W2940429062 cites W153428855 @default.
- W2940429062 cites W1547422835 @default.
- W2940429062 cites W1572271255 @default.
- W2940429062 cites W1586716019 @default.
- W2940429062 cites W1785580848 @default.
- W2940429062 cites W1835502273 @default.
- W2940429062 cites W1836480625 @default.
- W2940429062 cites W1840915948 @default.
- W2940429062 cites W1850426716 @default.
- W2940429062 cites W1912692550 @default.
- W2940429062 cites W1913767120 @default.
- W2940429062 cites W1957136694 @default.
- W2940429062 cites W1967692811 @default.
- W2940429062 cites W1967881866 @default.
- W2940429062 cites W1969945682 @default.
- W2940429062 cites W1970949335 @default.
- W2940429062 cites W1972625598 @default.
- W2940429062 cites W1972793256 @default.
- W2940429062 cites W1973604397 @default.
- W2940429062 cites W1974332498 @default.
- W2940429062 cites W1974409985 @default.
- W2940429062 cites W1974546855 @default.
- W2940429062 cites W1976150924 @default.
- W2940429062 cites W1976441209 @default.
- W2940429062 cites W1976949137 @default.
- W2940429062 cites W1977267072 @default.
- W2940429062 cites W1982460960 @default.
- W2940429062 cites W1983565617 @default.
- W2940429062 cites W1983982834 @default.
- W2940429062 cites W1984085714 @default.
- W2940429062 cites W1985626907 @default.
- W2940429062 cites W1986674043 @default.
- W2940429062 cites W1987855842 @default.
- W2940429062 cites W1991265255 @default.
- W2940429062 cites W1991631628 @default.
- W2940429062 cites W1992724001 @default.
- W2940429062 cites W1992857831 @default.
- W2940429062 cites W1993287255 @default.
- W2940429062 cites W1993511165 @default.
- W2940429062 cites W1995630168 @default.
- W2940429062 cites W1997039314 @default.
- W2940429062 cites W1997813173 @default.
- W2940429062 cites W1998560601 @default.
- W2940429062 cites W1998845439 @default.
- W2940429062 cites W1999656616 @default.
- W2940429062 cites W1999718232 @default.
- W2940429062 cites W2000445643 @default.
- W2940429062 cites W2000963773 @default.
- W2940429062 cites W2001937385 @default.
- W2940429062 cites W2002061608 @default.
- W2940429062 cites W2004682948 @default.
- W2940429062 cites W2004840945 @default.
- W2940429062 cites W2005002977 @default.
- W2940429062 cites W2005767834 @default.
- W2940429062 cites W2010664998 @default.
- W2940429062 cites W2011559281 @default.
- W2940429062 cites W2011912935 @default.
- W2940429062 cites W2012035062 @default.
- W2940429062 cites W2012600855 @default.
- W2940429062 cites W2012670804 @default.
- W2940429062 cites W2012928718 @default.
- W2940429062 cites W2013689460 @default.
- W2940429062 cites W2013948993 @default.
- W2940429062 cites W2014746498 @default.
- W2940429062 cites W2015243552 @default.
- W2940429062 cites W2018548277 @default.
- W2940429062 cites W2020621201 @default.
- W2940429062 cites W2020681473 @default.
- W2940429062 cites W2023598683 @default.
- W2940429062 cites W2023618783 @default.
- W2940429062 cites W2025341515 @default.
- W2940429062 cites W2025348756 @default.
- W2940429062 cites W2025801301 @default.
- W2940429062 cites W2027074551 @default.
- W2940429062 cites W2027424508 @default.
- W2940429062 cites W2027881600 @default.
- W2940429062 cites W2030749349 @default.
- W2940429062 cites W2037461530 @default.
- W2940429062 cites W2037653456 @default.
- W2940429062 cites W2037673492 @default.
- W2940429062 cites W2038612772 @default.
- W2940429062 cites W2042350981 @default.
- W2940429062 cites W2042422855 @default.