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- W2940494077 abstract "Dual-specificity protein phosphatases comprise a protein phosphatase subfamily with selectivity towards mitogen-activated protein (MAP) kinases, also named MKPs, or mitogen-activated protein kinase (MAPK) phosphatases. As powerful regulators of the intensity and duration of MAPK signaling, a relevant role is envisioned for dual-specificity protein phosphatases (DUSPs) in the regulation of biological processes in the nervous system, such as differentiation, synaptic plasticity, and survival. Important neural mediators include nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) that contribute to DUSP transcriptional induction and post-translational mechanisms of DUSP protein stabilization to maintain neuronal survival and differentiation. Potent DUSP gene inducers also include cannabinoids, which preserve DUSP activity in inflammatory conditions. Additionally, nucleotides activating P2X7 and P2Y13 nucleotide receptors behave as novel players in the regulation of DUSP function. They increase cell survival in stressful conditions, regulating DUSP protein turnover and inducing DUSP gene expression. In general terms, in the context of neural cells exposed to damaging conditions, the recovery of DUSP activity is neuroprotective and counteracts pro-apoptotic over-activation of p38 and JNK. In addition, remarkable changes in DUSP function take place during the onset of neuropathologies. The restoration of proper DUSP levels and recovery of MAPK homeostasis underlie the therapeutic effect, indicating that DUSPs can be relevant targets for brain diseases." @default.
- W2940494077 created "2019-05-03" @default.
- W2940494077 creator A5000070721 @default.
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- W2940494077 creator A5070298983 @default.
- W2940494077 creator A5084888586 @default.
- W2940494077 date "2019-04-23" @default.
- W2940494077 modified "2023-10-17" @default.
- W2940494077 title "Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells" @default.
- W2940494077 cites W1473603974 @default.
- W2940494077 cites W1580906825 @default.
- W2940494077 cites W1875583344 @default.
- W2940494077 cites W1964632749 @default.
- W2940494077 cites W1965790167 @default.
- W2940494077 cites W1967248406 @default.
- W2940494077 cites W1968198979 @default.
- W2940494077 cites W1968740815 @default.
- W2940494077 cites W1969057876 @default.
- W2940494077 cites W1969918683 @default.
- W2940494077 cites W1971641482 @default.
- W2940494077 cites W1971925780 @default.
- W2940494077 cites W1975661186 @default.
- W2940494077 cites W1979657965 @default.
- W2940494077 cites W1983402821 @default.
- W2940494077 cites W1984945589 @default.
- W2940494077 cites W1985133272 @default.
- W2940494077 cites W1986005505 @default.
- W2940494077 cites W1988911139 @default.
- W2940494077 cites W1989734458 @default.
- W2940494077 cites W1999682415 @default.
- W2940494077 cites W2001250682 @default.
- W2940494077 cites W2001859505 @default.
- W2940494077 cites W2002468669 @default.
- W2940494077 cites W2003060606 @default.
- W2940494077 cites W2004378711 @default.
- W2940494077 cites W2004639056 @default.
- W2940494077 cites W2005558622 @default.
- W2940494077 cites W2007620493 @default.
- W2940494077 cites W2011417333 @default.
- W2940494077 cites W2012185326 @default.
- W2940494077 cites W2013800871 @default.
- W2940494077 cites W2015698672 @default.
- W2940494077 cites W2015852145 @default.
- W2940494077 cites W2020203409 @default.
- W2940494077 cites W2020583309 @default.
- W2940494077 cites W2020841800 @default.
- W2940494077 cites W2020976545 @default.
- W2940494077 cites W2023609305 @default.
- W2940494077 cites W2029073059 @default.
- W2940494077 cites W2035344076 @default.
- W2940494077 cites W2037815828 @default.
- W2940494077 cites W2039196164 @default.
- W2940494077 cites W2040904432 @default.
- W2940494077 cites W2041792523 @default.
- W2940494077 cites W2042017613 @default.
- W2940494077 cites W2045744965 @default.
- W2940494077 cites W2047152276 @default.
- W2940494077 cites W2047994580 @default.
- W2940494077 cites W2050252881 @default.
- W2940494077 cites W2050892991 @default.
- W2940494077 cites W2054139370 @default.
- W2940494077 cites W2058715711 @default.
- W2940494077 cites W2059394768 @default.
- W2940494077 cites W2060035717 @default.
- W2940494077 cites W2061694517 @default.
- W2940494077 cites W2063090348 @default.
- W2940494077 cites W2063467171 @default.
- W2940494077 cites W2069482416 @default.
- W2940494077 cites W2069499945 @default.
- W2940494077 cites W2069568866 @default.
- W2940494077 cites W2070180549 @default.
- W2940494077 cites W2070654072 @default.
- W2940494077 cites W2070761065 @default.
- W2940494077 cites W2071694536 @default.
- W2940494077 cites W2071900417 @default.
- W2940494077 cites W2072307972 @default.
- W2940494077 cites W2075278744 @default.
- W2940494077 cites W2075946905 @default.
- W2940494077 cites W2079289532 @default.
- W2940494077 cites W2080179797 @default.
- W2940494077 cites W2083076387 @default.
- W2940494077 cites W2083364214 @default.
- W2940494077 cites W2083534510 @default.
- W2940494077 cites W2084062482 @default.
- W2940494077 cites W2086920665 @default.
- W2940494077 cites W2087156154 @default.
- W2940494077 cites W2088481957 @default.
- W2940494077 cites W2089219424 @default.
- W2940494077 cites W2090296265 @default.
- W2940494077 cites W2091976202 @default.
- W2940494077 cites W2093380524 @default.
- W2940494077 cites W2093684645 @default.
- W2940494077 cites W2095795382 @default.
- W2940494077 cites W2095821804 @default.
- W2940494077 cites W2097939539 @default.