Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940505448> ?p ?o ?g. }
- W2940505448 endingPage "485" @default.
- W2940505448 startingPage "479" @default.
- W2940505448 abstract "Aims Radiation-induced heart disease is a late effect of cardiac irradiation and has been shown in patients with lymphoma and thoracic cancers. There is no established measurement tool to detect acute cardiac damage. However, high sensitivity troponin I and T (HsTnI and HsTnT) and echocardiograms have shown promise in some studies. A pilot trial was conducted to characterise whether these instruments may detect subclinical radiotherapy-induced cardiac damage. Materials and methods Eligible patients received high cardiac doses defined by either at least 30 Gy to 5% of cardiac volume or a mean dose of 4 Gy. HsTnI and HsTnT were measured before radiotherapy and after 2 and 4 weeks of radiotherapy; three-dimensional echocardiograms were completed before and 1 year after radiotherapy. Results Of 19 patients, the median ‘mean left ventricular dose’ was 3.1 Gy and the ‘mean cardiac dose’ was 8.6 Gy. Significant positive associations between HsTnI and HsTnT were observed at all time points, but there was no significant association with cardiac dose. The mean left ventricular dose and the maximum left ventricular dose were, however, associated with a decrease in ejection fraction (P = 0.054, 0.043) as well as an increase in left ventricular strain (P = 0.058). Conclusion This study suggests that HsTnI and HsTnT are intimately related, but detection of acute cardiac damage was not shown, potentially due to limitations of these markers or low radiotherapy doses using conformal techniques. Our results also suggest subacute damage at 1 year may depend on the dose to the left ventricle. Further studies are needed, as identification of early damage could facilitate the ability to closely monitor and intervene in patients at risk for radiation-induced heart disease." @default.
- W2940505448 created "2019-05-03" @default.
- W2940505448 creator A5007941548 @default.
- W2940505448 creator A5008801653 @default.
- W2940505448 creator A5018734713 @default.
- W2940505448 creator A5021890539 @default.
- W2940505448 creator A5026555468 @default.
- W2940505448 creator A5035628404 @default.
- W2940505448 creator A5042773636 @default.
- W2940505448 creator A5056512048 @default.
- W2940505448 creator A5069359085 @default.
- W2940505448 creator A5070203953 @default.
- W2940505448 creator A5070506894 @default.
- W2940505448 creator A5087929642 @default.
- W2940505448 creator A5091750803 @default.
- W2940505448 date "2019-07-01" @default.
- W2940505448 modified "2023-10-11" @default.
- W2940505448 title "MEDiastinal Irradiation and CArdio-Toxic Effects (MEDICATE): Exploring the Relationship between Cardiac Irradiation and High Sensitivity Troponins" @default.
- W2940505448 cites W1968899146 @default.
- W2940505448 cites W1984502501 @default.
- W2940505448 cites W1987019190 @default.
- W2940505448 cites W1987536026 @default.
- W2940505448 cites W1989192901 @default.
- W2940505448 cites W1990514890 @default.
- W2940505448 cites W1999909662 @default.
- W2940505448 cites W2003374912 @default.
- W2940505448 cites W2024765487 @default.
- W2940505448 cites W2033600419 @default.
- W2940505448 cites W2061452374 @default.
- W2940505448 cites W2073662365 @default.
- W2940505448 cites W2076101655 @default.
- W2940505448 cites W2076343366 @default.
- W2940505448 cites W2108061720 @default.
- W2940505448 cites W2136867800 @default.
- W2940505448 cites W2154375587 @default.
- W2940505448 cites W2162343488 @default.
- W2940505448 cites W2164982021 @default.
- W2940505448 cites W2508944852 @default.
- W2940505448 cites W2581615902 @default.
- W2940505448 cites W2806483049 @default.
- W2940505448 doi "https://doi.org/10.1016/j.clon.2019.04.003" @default.
- W2940505448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31031066" @default.
- W2940505448 hasPublicationYear "2019" @default.
- W2940505448 type Work @default.
- W2940505448 sameAs 2940505448 @default.
- W2940505448 citedByCount "6" @default.
- W2940505448 countsByYear W29405054482019 @default.
- W2940505448 countsByYear W29405054482020 @default.
- W2940505448 countsByYear W29405054482021 @default.
- W2940505448 countsByYear W29405054482023 @default.
- W2940505448 crossrefType "journal-article" @default.
- W2940505448 hasAuthorship W2940505448A5007941548 @default.
- W2940505448 hasAuthorship W2940505448A5008801653 @default.
- W2940505448 hasAuthorship W2940505448A5018734713 @default.
- W2940505448 hasAuthorship W2940505448A5021890539 @default.
- W2940505448 hasAuthorship W2940505448A5026555468 @default.
- W2940505448 hasAuthorship W2940505448A5035628404 @default.
- W2940505448 hasAuthorship W2940505448A5042773636 @default.
- W2940505448 hasAuthorship W2940505448A5056512048 @default.
- W2940505448 hasAuthorship W2940505448A5069359085 @default.
- W2940505448 hasAuthorship W2940505448A5070203953 @default.
- W2940505448 hasAuthorship W2940505448A5070506894 @default.
- W2940505448 hasAuthorship W2940505448A5087929642 @default.
- W2940505448 hasAuthorship W2940505448A5091750803 @default.
- W2940505448 hasConcept C113280763 @default.
- W2940505448 hasConcept C126322002 @default.
- W2940505448 hasConcept C164705383 @default.
- W2940505448 hasConcept C2778198053 @default.
- W2940505448 hasConcept C509974204 @default.
- W2940505448 hasConcept C71924100 @default.
- W2940505448 hasConcept C78085059 @default.
- W2940505448 hasConceptScore W2940505448C113280763 @default.
- W2940505448 hasConceptScore W2940505448C126322002 @default.
- W2940505448 hasConceptScore W2940505448C164705383 @default.
- W2940505448 hasConceptScore W2940505448C2778198053 @default.
- W2940505448 hasConceptScore W2940505448C509974204 @default.
- W2940505448 hasConceptScore W2940505448C71924100 @default.
- W2940505448 hasConceptScore W2940505448C78085059 @default.
- W2940505448 hasFunder F4320306901 @default.
- W2940505448 hasIssue "7" @default.
- W2940505448 hasLocation W29405054481 @default.
- W2940505448 hasLocation W29405054482 @default.
- W2940505448 hasOpenAccess W2940505448 @default.
- W2940505448 hasPrimaryLocation W29405054481 @default.
- W2940505448 hasRelatedWork W2053992978 @default.
- W2940505448 hasRelatedWork W2093528096 @default.
- W2940505448 hasRelatedWork W2411828280 @default.
- W2940505448 hasRelatedWork W2789517405 @default.
- W2940505448 hasRelatedWork W2912421895 @default.
- W2940505448 hasRelatedWork W2973591247 @default.
- W2940505448 hasRelatedWork W3188428900 @default.
- W2940505448 hasRelatedWork W4238002189 @default.
- W2940505448 hasRelatedWork W4379647269 @default.
- W2940505448 hasRelatedWork W4382048704 @default.
- W2940505448 hasVolume "31" @default.
- W2940505448 isParatext "false" @default.
- W2940505448 isRetracted "false" @default.
- W2940505448 magId "2940505448" @default.