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• W2940548201 abstract "Purpose of review Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including both Fab and Fc-mediated antibody responses. We also highlight recent studies showing the interplay between these functions, focusing primarily on studies published in the last year. Recent findings Identification and characterization of bNAb donors continues to provide insights into viral factors that are potentially translatable to vaccine design. Improved and more diverse measures of Fc effector function, and modulators thereof, are enabling a deeper understanding of their role in infection. New data providing mechanistic links between the innate and adaptive humoral immune responses are creating exciting opportunities for vaccine strategies, with the aim of eliciting a polyfunctional protective response. Summary New insights into the overall humoral response to HIV infection are defining diverse and synergistic mechanisms required for antibody protection from HIV through vaccination." @default.
• W2940548201 created "2019-05-03" @default.
• W2940548201 creator A5030822254 @default.
• W2940548201 creator A5046502364 @default.
• W2940548201 date "2019-07-01" @default.
• W2940548201 modified "2023-10-18" @default.
• W2940548201 title "The antibody response in HIV-1-infected donors" @default.
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• W2940548201 doi "https://doi.org/10.1097/coh.0000000000000559" @default.
• W2940548201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7324637" @default.
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