Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940555664> ?p ?o ?g. }
- W2940555664 endingPage "979" @default.
- W2940555664 startingPage "968" @default.
- W2940555664 abstract "Conventional anti-tumour chemotherapy is facing the challenges of poor specificity, high toxicity and drug resistance. Tumour microenvironment (TME) plays a critical role in tumour development and drug resistance. To address this problem, we constructed a novel anti-tumour nanoparticle platform RBC@BPQDs-DOX/KIR, black phosphorus nanoparticle quantum dots (BPQDs) with one of the chemotherapeutics (doxorubicin, DOX) and an anti-inflammatory traditional Chinese medicine active component (Kirenol, KIR). Red blood cell membrane (RBCm) vesicles were used as the shell to envelop several nanocores. The combination of DOX and KIR may promote therapeutic efficacy, at which the anti-apoptotic effect of the tumour cells was inhibited (by downregulating Bcl-2 and upregulating Bax) and the tumour progression-related inflammatory factors, such as tumour necrosis factor α (TNF-α) and interleukin-6 (IL-6) were downregulated. Furthermore, TME was remodelled and the anti-tumour effect of DOX was magnified. RBCm imparts high biocompatibility and enhanced permeability and retention (EPR) effects to RBC@BPQDs-DOX/KIR, thus enhancing its tumour passively targetability. Overall, the RBCm-camouflaged drug delivery system RBC@BPQDs-DOX/KIR as a promising therapy for targeted chemotherapeutics and anti-inflammatory therapeutics may provide a specific and highly efficient anti-tumour treatment choice." @default.
- W2940555664 created "2019-05-03" @default.
- W2940555664 creator A5008932652 @default.
- W2940555664 creator A5010630605 @default.
- W2940555664 creator A5035519834 @default.
- W2940555664 creator A5043738210 @default.
- W2940555664 creator A5052883326 @default.
- W2940555664 creator A5079289428 @default.
- W2940555664 creator A5090069742 @default.
- W2940555664 date "2019-03-18" @default.
- W2940555664 modified "2023-10-14" @default.
- W2940555664 title "Anti-tumour effects of red blood cell membrane-camouflaged black phosphorous quantum dots combined with chemotherapy and anti-inflammatory therapy" @default.
- W2940555664 cites W1533021978 @default.
- W2940555664 cites W1965037168 @default.
- W2940555664 cites W1974784131 @default.
- W2940555664 cites W1980052502 @default.
- W2940555664 cites W1992912767 @default.
- W2940555664 cites W2019633596 @default.
- W2940555664 cites W2037048276 @default.
- W2940555664 cites W2039949492 @default.
- W2940555664 cites W2053929414 @default.
- W2940555664 cites W2074213282 @default.
- W2940555664 cites W2117692326 @default.
- W2940555664 cites W2125610331 @default.
- W2940555664 cites W2129304478 @default.
- W2940555664 cites W2132841383 @default.
- W2940555664 cites W2145542965 @default.
- W2940555664 cites W2146126039 @default.
- W2940555664 cites W2164664027 @default.
- W2940555664 cites W2167807253 @default.
- W2940555664 cites W2282724676 @default.
- W2940555664 cites W2397132524 @default.
- W2940555664 cites W2398721297 @default.
- W2940555664 cites W2409057459 @default.
- W2940555664 cites W2412252937 @default.
- W2940555664 cites W2486291976 @default.
- W2940555664 cites W2514184675 @default.
- W2940555664 cites W2557880977 @default.
- W2940555664 cites W2604329262 @default.
- W2940555664 cites W2609492457 @default.
- W2940555664 cites W2732051673 @default.
- W2940555664 cites W2756090439 @default.
- W2940555664 cites W2770688707 @default.
- W2940555664 cites W2780622257 @default.
- W2940555664 cites W2795372495 @default.
- W2940555664 cites W2799696186 @default.
- W2940555664 cites W2851995651 @default.
- W2940555664 cites W2890535677 @default.
- W2940555664 cites W2904953303 @default.
- W2940555664 cites W4250431414 @default.
- W2940555664 doi "https://doi.org/10.1080/21691401.2019.1584110" @default.
- W2940555664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30880468" @default.
- W2940555664 hasPublicationYear "2019" @default.
- W2940555664 type Work @default.
- W2940555664 sameAs 2940555664 @default.
- W2940555664 citedByCount "23" @default.
- W2940555664 countsByYear W29405556642019 @default.
- W2940555664 countsByYear W29405556642020 @default.
- W2940555664 countsByYear W29405556642021 @default.
- W2940555664 countsByYear W29405556642022 @default.
- W2940555664 countsByYear W29405556642023 @default.
- W2940555664 crossrefType "journal-article" @default.
- W2940555664 hasAuthorship W2940555664A5008932652 @default.
- W2940555664 hasAuthorship W2940555664A5010630605 @default.
- W2940555664 hasAuthorship W2940555664A5035519834 @default.
- W2940555664 hasAuthorship W2940555664A5043738210 @default.
- W2940555664 hasAuthorship W2940555664A5052883326 @default.
- W2940555664 hasAuthorship W2940555664A5079289428 @default.
- W2940555664 hasAuthorship W2940555664A5090069742 @default.
- W2940555664 hasBestOaLocation W29405556641 @default.
- W2940555664 hasConcept C114851261 @default.
- W2940555664 hasConcept C126322002 @default.
- W2940555664 hasConcept C178790620 @default.
- W2940555664 hasConcept C17991360 @default.
- W2940555664 hasConcept C185592680 @default.
- W2940555664 hasConcept C190283241 @default.
- W2940555664 hasConcept C203014093 @default.
- W2940555664 hasConcept C2776694085 @default.
- W2940555664 hasConcept C2779820397 @default.
- W2940555664 hasConcept C2780035454 @default.
- W2940555664 hasConcept C2781303535 @default.
- W2940555664 hasConcept C502942594 @default.
- W2940555664 hasConcept C55493867 @default.
- W2940555664 hasConcept C71924100 @default.
- W2940555664 hasConcept C86803240 @default.
- W2940555664 hasConcept C89423630 @default.
- W2940555664 hasConcept C98274493 @default.
- W2940555664 hasConceptScore W2940555664C114851261 @default.
- W2940555664 hasConceptScore W2940555664C126322002 @default.
- W2940555664 hasConceptScore W2940555664C178790620 @default.
- W2940555664 hasConceptScore W2940555664C17991360 @default.
- W2940555664 hasConceptScore W2940555664C185592680 @default.
- W2940555664 hasConceptScore W2940555664C190283241 @default.
- W2940555664 hasConceptScore W2940555664C203014093 @default.
- W2940555664 hasConceptScore W2940555664C2776694085 @default.
- W2940555664 hasConceptScore W2940555664C2779820397 @default.
- W2940555664 hasConceptScore W2940555664C2780035454 @default.
- W2940555664 hasConceptScore W2940555664C2781303535 @default.