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- W2940571490 abstract "Abstract An efficient one‐pot enzymatic synthesis of cardiac glycosides with varied sugar chain lengths (average yield >80%) was carried out through sequential glycosylation using a steroid glycosyltransferase UGT74AN3 from Catharanthus roseus and a cyclodextrin glycosyltransferase from Bacillus licheniformis . A series of cardiac glycosides were obtained and showed enhanced affinity and selectivity for inhibition of the α2 isoform of Na + /K + ‐ATPase. These findings demonstrate the significant potential of the one‐pot biocatalytic approach in the synthesis of diverse cardiac glycosides as potentially safer cardiotonic agents. magnified image" @default.
- W2940571490 created "2019-05-03" @default.
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- W2940571490 date "2019-05-13" @default.
- W2940571490 modified "2023-10-18" @default.
- W2940571490 title "An Efficient One‐Pot Enzymatic Synthesis of Cardiac Glycosides with Varied Sugar Chain Lengths" @default.
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- W2940571490 doi "https://doi.org/10.1002/adsc.201900227" @default.
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