FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940698879> ?p ?o ?g. }

• W2940698879 endingPage "2065" @default.
• W2940698879 startingPage "2065" @default.
• W2940698879 abstract "The nucleus of the solitary tract (NTS) receives visceral information via the solitary tract (ST) that comprises the sensory components of the cranial nerves VII, IX and X. The Transient Receptor Potential Ankyrin 1 (TRPA1) ion channels are non-selective cation channels that are expressed primarily in pain-related sensory neurons and nerve fibers. Thus, TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. This hypothesis was tested and confirmed in the present study using acute brainstem slices and caudal NTS neurons by RT-PCR, immunostaining and patch-clamp electrophysiology. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers. Electrophysiological recordings detected activation of presynaptic TRPA1 in glutamatergic terminals synapsing on caudal NTS neurons evidenced by the enhanced glutamatergic synaptic neurotransmission in the presence of TRPA1 agonists. The requirement of TRPA1 for modulation of spontaneous synaptic activity was confirmed using TRPA1 knockout mice where TRPA1 agonists failed to alter synaptic efficacy. Thus, this study provides the first evidence of the TRPA1-dependent modulation of the primary afferent inputs to the caudal NTS. These results suggest that the second order caudal NTS neurons act as a TRPA1-dependent interface for visceral noxious-innocuous integration at the level of the caudal brainstem." @default.
• W2940698879 created "2019-05-03" @default.
• W2940698879 creator A5021915783 @default.
• W2940698879 creator A5083561854 @default.
• W2940698879 creator A5087616224 @default.
• W2940698879 date "2019-04-26" @default.
• W2940698879 modified "2023-09-27" @default.
• W2940698879 title "Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract" @default.
• W2940698879 cites W1492591187 @default.
• W2940698879 cites W1511198581 @default.
• W2940698879 cites W1541414763 @default.
• W2940698879 cites W1598659726 @default.
• W2940698879 cites W1870440768 @default.
• W2940698879 cites W1968916283 @default.
• W2940698879 cites W1971584561 @default.
• W2940698879 cites W1973442365 @default.
• W2940698879 cites W1973856059 @default.
• W2940698879 cites W1976019322 @default.
• W2940698879 cites W1980010331 @default.
• W2940698879 cites W1981478519 @default.
• W2940698879 cites W1988860455 @default.
• W2940698879 cites W1996116448 @default.
• W2940698879 cites W1998467441 @default.
• W2940698879 cites W1999069112 @default.
• W2940698879 cites W2003645311 @default.
• W2940698879 cites W2006689459 @default.
• W2940698879 cites W2009967312 @default.
• W2940698879 cites W2020833052 @default.
• W2940698879 cites W2020919581 @default.
• W2940698879 cites W2024689361 @default.
• W2940698879 cites W2026256841 @default.
• W2940698879 cites W2026532515 @default.
• W2940698879 cites W2027661382 @default.
• W2940698879 cites W2031586330 @default.
• W2940698879 cites W2033938643 @default.
• W2940698879 cites W2035257142 @default.
• W2940698879 cites W2037057990 @default.
• W2940698879 cites W2051950587 @default.
• W2940698879 cites W2055211686 @default.
• W2940698879 cites W2056550783 @default.
• W2940698879 cites W2057402123 @default.
• W2940698879 cites W2060002356 @default.
• W2940698879 cites W2062978707 @default.
• W2940698879 cites W2062993520 @default.
• W2940698879 cites W2071657406 @default.
• W2940698879 cites W2074027763 @default.
• W2940698879 cites W2075100277 @default.
• W2940698879 cites W2077166985 @default.
• W2940698879 cites W2078426381 @default.
• W2940698879 cites W2086006585 @default.
• W2940698879 cites W2086599614 @default.
• W2940698879 cites W2090592412 @default.
• W2940698879 cites W2098074651 @default.
• W2940698879 cites W2099414466 @default.
• W2940698879 cites W2100891931 @default.
• W2940698879 cites W2106347460 @default.
• W2940698879 cites W2108629233 @default.
• W2940698879 cites W2109008155 @default.
• W2940698879 cites W2109879418 @default.
• W2940698879 cites W2118026478 @default.
• W2940698879 cites W2120229762 @default.
• W2940698879 cites W2124418433 @default.
• W2940698879 cites W2126181026 @default.
• W2940698879 cites W2127012396 @default.
• W2940698879 cites W2129690290 @default.
• W2940698879 cites W2130666985 @default.
• W2940698879 cites W2138871581 @default.
• W2940698879 cites W2144014198 @default.
• W2940698879 cites W2149676780 @default.
• W2940698879 cites W2156733405 @default.
• W2940698879 cites W2157297172 @default.
• W2940698879 cites W2159134058 @default.
• W2940698879 cites W2160983133 @default.
• W2940698879 cites W2161123433 @default.
• W2940698879 cites W2278324798 @default.
• W2940698879 cites W2332618518 @default.
• W2940698879 cites W2397934137 @default.
• W2940698879 cites W2412180315 @default.
• W2940698879 doi "https://doi.org/10.3390/ijms20092065" @default.
• W2940698879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6539857" @default.
• W2940698879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31027359" @default.
• W2940698879 hasPublicationYear "2019" @default.
• W2940698879 type Work @default.
• W2940698879 sameAs 2940698879 @default.
• W2940698879 citedByCount "4" @default.
• W2940698879 countsByYear W29406988792019 @default.
• W2940698879 countsByYear W29406988792020 @default.
• W2940698879 countsByYear W29406988792022 @default.
• W2940698879 countsByYear W29406988792023 @default.
• W2940698879 crossrefType "journal-article" @default.
• W2940698879 hasAuthorship W2940698879A5021915783 @default.
• W2940698879 hasAuthorship W2940698879A5083561854 @default.
• W2940698879 hasAuthorship W2940698879A5087616224 @default.
• W2940698879 hasBestOaLocation W29406988791 @default.
• W2940698879 hasConcept C104317684 @default.
• W2940698879 hasConcept C155164980 @default.
• W2940698879 hasConcept C169760540 @default.
• W2940698879 hasConcept C170493617 @default.

• next