Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940774809> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2940774809 abstract "Influenza virus is the causative agent of the ‘flu’. According to the World Health Organisation, Influenza causes up to 5 million cases of severe flu and 500 000 deaths annually. To release its genome inside the cell and start an infection, Influenza virus must fuse its envelope with the endosomal membrane of the host, making this process an excellent drug target. In order to attempt to control, or better yet, eradicate this pathogen, a greater understanding of its entry mechanism, a fundamental aspect of the viral life cycle, is required. It is well established that Influenza A virus (IAV) fusion is driven by the viral glycoprotein hemagglutinin (HA), which when exposed to low pH transitions from a meta-stable pre-fusion to post-fusion state. However, it is becoming increasingly apparent that the ionic balance of the endosomes also has a significant role in the entry of enveloped viruses. Specifically, our preliminary studies on Influenza virus suggest that K+ concentrations within the endocytic pathway play a significant role in Influenza A fusion events. Through the use of broad-spectrum K+ channel inhibitors, a dose-dependant reduction in Influenza infectivity in tissue culture can be observed. Further to these studies, we have isolated Affimers (novel antibody-like proteins that can be produced in large quantities in E. coli) that recognise HAs from different Influenza subtypes (H3N2 and H1N1). Using these Affimers, we aim to develop an early detection method to distinguish between bacterial respiratory infections and ‘the flu’ to alleviate mounting pressures on an already diminishing antibiotic treatment system." @default.
- W2940774809 created "2019-05-03" @default.
- W2940774809 creator A5009168603 @default.
- W2940774809 creator A5028302065 @default.
- W2940774809 creator A5028489397 @default.
- W2940774809 creator A5033909787 @default.
- W2940774809 creator A5037719383 @default.
- W2940774809 creator A5043310239 @default.
- W2940774809 date "2019-03-01" @default.
- W2940774809 modified "2023-10-06" @default.
- W2940774809 title "Unravelling the features of Influenza as entry mechanism" @default.
- W2940774809 doi "https://doi.org/10.1099/acmi.ac2019.po0546" @default.
- W2940774809 hasPublicationYear "2019" @default.
- W2940774809 type Work @default.
- W2940774809 sameAs 2940774809 @default.
- W2940774809 citedByCount "0" @default.
- W2940774809 crossrefType "journal-article" @default.
- W2940774809 hasAuthorship W2940774809A5009168603 @default.
- W2940774809 hasAuthorship W2940774809A5028302065 @default.
- W2940774809 hasAuthorship W2940774809A5028489397 @default.
- W2940774809 hasAuthorship W2940774809A5033909787 @default.
- W2940774809 hasAuthorship W2940774809A5037719383 @default.
- W2940774809 hasAuthorship W2940774809A5043310239 @default.
- W2940774809 hasBestOaLocation W29407748091 @default.
- W2940774809 hasConcept C102747710 @default.
- W2940774809 hasConcept C103038307 @default.
- W2940774809 hasConcept C140704245 @default.
- W2940774809 hasConcept C1491633281 @default.
- W2940774809 hasConcept C159047783 @default.
- W2940774809 hasConcept C2522874641 @default.
- W2940774809 hasConcept C25897203 @default.
- W2940774809 hasConcept C2777546802 @default.
- W2940774809 hasConcept C2778692840 @default.
- W2940774809 hasConcept C54355233 @default.
- W2940774809 hasConcept C58475186 @default.
- W2940774809 hasConcept C86803240 @default.
- W2940774809 hasConcept C89423630 @default.
- W2940774809 hasConcept C97380033 @default.
- W2940774809 hasConceptScore W2940774809C102747710 @default.
- W2940774809 hasConceptScore W2940774809C103038307 @default.
- W2940774809 hasConceptScore W2940774809C140704245 @default.
- W2940774809 hasConceptScore W2940774809C1491633281 @default.
- W2940774809 hasConceptScore W2940774809C159047783 @default.
- W2940774809 hasConceptScore W2940774809C2522874641 @default.
- W2940774809 hasConceptScore W2940774809C25897203 @default.
- W2940774809 hasConceptScore W2940774809C2777546802 @default.
- W2940774809 hasConceptScore W2940774809C2778692840 @default.
- W2940774809 hasConceptScore W2940774809C54355233 @default.
- W2940774809 hasConceptScore W2940774809C58475186 @default.
- W2940774809 hasConceptScore W2940774809C86803240 @default.
- W2940774809 hasConceptScore W2940774809C89423630 @default.
- W2940774809 hasConceptScore W2940774809C97380033 @default.
- W2940774809 hasLocation W29407748091 @default.
- W2940774809 hasOpenAccess W2940774809 @default.
- W2940774809 hasPrimaryLocation W29407748091 @default.
- W2940774809 hasRelatedWork W1533492557 @default.
- W2940774809 hasRelatedWork W1970069062 @default.
- W2940774809 hasRelatedWork W198451171 @default.
- W2940774809 hasRelatedWork W2014092278 @default.
- W2940774809 hasRelatedWork W2110590479 @default.
- W2940774809 hasRelatedWork W2130415089 @default.
- W2940774809 hasRelatedWork W2151660827 @default.
- W2940774809 hasRelatedWork W2242410361 @default.
- W2940774809 hasRelatedWork W2338709508 @default.
- W2940774809 hasRelatedWork W2413280669 @default.
- W2940774809 hasRelatedWork W2463832694 @default.
- W2940774809 hasRelatedWork W2524512366 @default.
- W2940774809 hasRelatedWork W252962932 @default.
- W2940774809 hasRelatedWork W2811479613 @default.
- W2940774809 hasRelatedWork W2891350344 @default.
- W2940774809 hasRelatedWork W3035468402 @default.
- W2940774809 hasRelatedWork W3087426745 @default.
- W2940774809 hasRelatedWork W3177897961 @default.
- W2940774809 hasRelatedWork W3192150817 @default.
- W2940774809 hasRelatedWork W2251043723 @default.
- W2940774809 isParatext "false" @default.
- W2940774809 isRetracted "false" @default.
- W2940774809 magId "2940774809" @default.
- W2940774809 workType "article" @default.