FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940781680> ?p ?o ?g. }

• W2940781680 endingPage "988" @default.
• W2940781680 startingPage "982" @default.
• W2940781680 abstract "Household food insecurity (HFI) is a stressor that is associated with type 2 diabetes (T2D). However, little is known about HFI and the insulin resistance (IR) underlying T2D, and the mechanisms involved. We examined the cross-sectional association between HFI and IR among low-income Latinos with T2D and tested whether inflammation and stress hormones mediated this association. HFI was measured with the 6-item US Household Food Security Survey module. IR was calculated from fasting plasma blood glucose and serum insulin. Inflammation was indicated by high-sensitivity C-reactive protein (hsCRP), and stress hormones included urinary cortisol, metanephrine, and normetanephrine. To test for an indirect effect of HFI on homeostasis model assessment of IR, a parallel multiple mediation model was run with biological markers that significantly differed between food security status—entered as mediators in the model. We used 95% bias-corrected bootstrap CIs, with 10,000 bootstrap samples, to assess the significance of the indirect effects. The 121 participants with T2D were primarily Puerto Rican (85.8%), aged mean = 60.7 y, and 74% were female. Eighty-two (68%) were classified as food insecure. Compared with food-secure individuals, food-insecure individuals had a significantly higher IR [mean difference (Δ) = 7.21, P = 0.001], insulin (Δ = 9.7, P = 0.019), glucose (Δ = 41, P < 0.001), hsCRP (Δ = 0.8, P = 0.008), cortisol (Δ = 21, P = 0.045), and total cholesterol (Δ = 29, P = 0.004). Groups did not differ on other lipids, metanephrine, normetanephrine, or A1c. The mediation model showed a significant direct effect of HFI on hsCRP (P = 0.020) and on cortisol (P = 0.011). There was a direct effect of cortisol (P = 0.013), hsCRP (P = 0.044), and HFI on IR (P = 0.015). The total combined indirect effect of HFI through cortisol and hsCRP indicated partial mediation. Among Latinos with T2D, HFI is associated with IR partially through inflammation and stress hormones. Interventions to ameliorate HFI and mitigate its effects on inflammation, stress, and IR are warranted. This trial was registered at clinicaltrials.gov as NCT01578096." @default.
• W2940781680 created "2019-05-03" @default.
• W2940781680 creator A5017749784 @default.
• W2940781680 creator A5026473845 @default.
• W2940781680 creator A5048911601 @default.
• W2940781680 creator A5061586410 @default.
• W2940781680 creator A5080286731 @default.
• W2940781680 creator A5087536047 @default.
• W2940781680 creator A5089116078 @default.
• W2940781680 date "2019-06-01" @default.
• W2940781680 modified "2023-10-17" @default.
• W2940781680 title "Inflammation and Stress Biomarkers Mediate the Association between Household Food Insecurity and Insulin Resistance among Latinos with Type 2 Diabetes" @default.
• W2940781680 cites W1538516183 @default.
• W2940781680 cites W1848120476 @default.
• W2940781680 cites W1949639572 @default.
• W2940781680 cites W1966865510 @default.
• W2940781680 cites W1969952972 @default.
• W2940781680 cites W1976814494 @default.
• W2940781680 cites W1978046231 @default.
• W2940781680 cites W1987413564 @default.
• W2940781680 cites W1996967703 @default.
• W2940781680 cites W2011965225 @default.
• W2940781680 cites W2026472514 @default.
• W2940781680 cites W2040785944 @default.
• W2940781680 cites W2059877874 @default.
• W2940781680 cites W2068951955 @default.
• W2940781680 cites W2073669844 @default.
• W2940781680 cites W2073727589 @default.
• W2940781680 cites W2073752934 @default.
• W2940781680 cites W2077154939 @default.
• W2940781680 cites W2085329788 @default.
• W2940781680 cites W2085457020 @default.
• W2940781680 cites W2092021333 @default.
• W2940781680 cites W2093274439 @default.
• W2940781680 cites W2094729036 @default.
• W2940781680 cites W2106132925 @default.
• W2940781680 cites W2110743581 @default.
• W2940781680 cites W2112801314 @default.
• W2940781680 cites W2113168655 @default.
• W2940781680 cites W2115373173 @default.
• W2940781680 cites W2116211264 @default.
• W2940781680 cites W2116369874 @default.
• W2940781680 cites W2120689760 @default.
• W2940781680 cites W2123026265 @default.
• W2940781680 cites W2128050336 @default.
• W2940781680 cites W2136201894 @default.
• W2940781680 cites W2151508677 @default.
• W2940781680 cites W2152884490 @default.
• W2940781680 cites W2156029791 @default.
• W2940781680 cites W2158818907 @default.
• W2940781680 cites W2160234571 @default.
• W2940781680 cites W2166941013 @default.
• W2940781680 cites W2168759057 @default.
• W2940781680 cites W2183484947 @default.
• W2940781680 cites W2193470118 @default.
• W2940781680 cites W2325293870 @default.
• W2940781680 cites W2334787351 @default.
• W2940781680 cites W2340335365 @default.
• W2940781680 cites W2394888164 @default.
• W2940781680 cites W2464849324 @default.
• W2940781680 cites W2487087511 @default.
• W2940781680 cites W2495791844 @default.
• W2940781680 cites W2524898238 @default.
• W2940781680 cites W2558459098 @default.
• W2940781680 cites W2607031541 @default.
• W2940781680 cites W2725223377 @default.
• W2940781680 cites W2736391215 @default.
• W2940781680 cites W2766577850 @default.
• W2940781680 cites W2786110056 @default.
• W2940781680 cites W2799406775 @default.
• W2940781680 cites W982923451 @default.
• W2940781680 doi "https://doi.org/10.1093/jn/nxz021" @default.
• W2940781680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6543200" @default.
• W2940781680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31006809" @default.
• W2940781680 hasPublicationYear "2019" @default.
• W2940781680 type Work @default.
• W2940781680 sameAs 2940781680 @default.
• W2940781680 citedByCount "15" @default.
• W2940781680 countsByYear W29407816802020 @default.
• W2940781680 countsByYear W29407816802021 @default.
• W2940781680 countsByYear W29407816802022 @default.
• W2940781680 countsByYear W29407816802023 @default.
• W2940781680 crossrefType "journal-article" @default.
• W2940781680 hasAuthorship W2940781680A5017749784 @default.
• W2940781680 hasAuthorship W2940781680A5026473845 @default.
• W2940781680 hasAuthorship W2940781680A5048911601 @default.
• W2940781680 hasAuthorship W2940781680A5061586410 @default.
• W2940781680 hasAuthorship W2940781680A5080286731 @default.
• W2940781680 hasAuthorship W2940781680A5087536047 @default.
• W2940781680 hasAuthorship W2940781680A5089116078 @default.
• W2940781680 hasBestOaLocation W29407816801 @default.
• W2940781680 hasConcept C118518473 @default.
• W2940781680 hasConcept C126322002 @default.
• W2940781680 hasConcept C134018914 @default.
• W2940781680 hasConcept C17744445 @default.
• W2940781680 hasConcept C179420905 @default.
• W2940781680 hasConcept C18903297 @default.
• W2940781680 hasConcept C199539241 @default.

• next