Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940874323> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2940874323 endingPage "13" @default.
- W2940874323 startingPage "7" @default.
- W2940874323 abstract "Introduction: According to the World Health Organisation (WHO), all HIV exposed infants should be tested by DriedBlood Spots (DBS)-Polymerase Chain Reaction (PCR) before or at 6 weeks of age, in the so-called early infant diagnosis(EID) programme. This is because there have been prior reports of high morbidity and mortality in HIV-infected infantsand children due to inadequate care and treatment in many developing countries, mostly due to unknown HIV status. EIDtesting is a crucial step to facilitate early access to antiretroviral treatment (ART). In order to inform clinicians, policymakers and the public, we carried out a study to determine specimen rejection rate and the reasons for specimenrejection by retrospectively reviewing records of Dried Blood Spot (DBS) samples received at Mutare Provincial HospitalMolecular Diagnostics Laboratory for HIV EID in Zimbabwe.Aim of Study: To determine the specimen rejection rate and reasons for sample rejection at the EID Laboratory atMutare Provincial Hospital as a way to ensure continuous availability of good quality diagnostic systems for HIV infectedwomen, their infants and families.Methods: This was a cross-sectional retrospective study conducted on data for samples submitted to Mutare ProvincialHospital Molecular Diagnostics Laboratory. The data was collected over a 1-year period from January 2015 to December2015 and was retrieved from the laboratory’s information database in January 2016. The records included date ofspecimen collection; date specimen was received at the laboratory and reasons for specimen rejection.Results: The specimen rejection rate was 10.7%. The reasons for rejection included improper specimen collection(24.8%), no specimen received (12.6%), multiple specimens packed in one sample pack (17.2%), specimens and formsnot labelled correctly (8.5%), specimens tested that requested for a new specimen due to machine error hence rejectedduring testing (16.6%), specimens tested but failed (8.2%) and specimens tested with an indeterminate result (12.2%).Conclusion: The study demonstrates that DBS specimen rejection in our setting (10%) is far higher than the 1-3%reported by the Clinton Health Access Initiatives, a global organisation spearheading research on HIV diagnostic tests inlow and middle income countries. Rejection was mainly due to human error (83.4%) hence this necessitates intensifiedtraining and monitoring of local personnel and integrating quality policies for specimen collection and processing toprevent specimen rejection. Other considerations could include continuous counselling of clinicians and medicallaboratory scientists in order to improve sample quality and specimen handling as a way to achieve the goals of thenational EID program." @default.
- W2940874323 created "2019-05-03" @default.
- W2940874323 creator A5023599908 @default.
- W2940874323 creator A5023780434 @default.
- W2940874323 creator A5028414326 @default.
- W2940874323 creator A5029181803 @default.
- W2940874323 creator A5029756434 @default.
- W2940874323 creator A5063700432 @default.
- W2940874323 date "2018-07-31" @default.
- W2940874323 modified "2023-09-23" @default.
- W2940874323 title "Early Infant Diagnosis Specimen Rejection Rate at Mutare Provincial Hospital Laboratory, Zimbabwe" @default.
- W2940874323 hasPublicationYear "2018" @default.
- W2940874323 type Work @default.
- W2940874323 sameAs 2940874323 @default.
- W2940874323 citedByCount "0" @default.
- W2940874323 crossrefType "journal-article" @default.
- W2940874323 hasAuthorship W2940874323A5023599908 @default.
- W2940874323 hasAuthorship W2940874323A5023780434 @default.
- W2940874323 hasAuthorship W2940874323A5028414326 @default.
- W2940874323 hasAuthorship W2940874323A5029181803 @default.
- W2940874323 hasAuthorship W2940874323A5029756434 @default.
- W2940874323 hasAuthorship W2940874323A5063700432 @default.
- W2940874323 hasConcept C141071460 @default.
- W2940874323 hasConcept C167135981 @default.
- W2940874323 hasConcept C187212893 @default.
- W2940874323 hasConcept C2776597655 @default.
- W2940874323 hasConcept C3013748606 @default.
- W2940874323 hasConcept C512399662 @default.
- W2940874323 hasConcept C54355233 @default.
- W2940874323 hasConcept C71924100 @default.
- W2940874323 hasConcept C86803240 @default.
- W2940874323 hasConceptScore W2940874323C141071460 @default.
- W2940874323 hasConceptScore W2940874323C167135981 @default.
- W2940874323 hasConceptScore W2940874323C187212893 @default.
- W2940874323 hasConceptScore W2940874323C2776597655 @default.
- W2940874323 hasConceptScore W2940874323C3013748606 @default.
- W2940874323 hasConceptScore W2940874323C512399662 @default.
- W2940874323 hasConceptScore W2940874323C54355233 @default.
- W2940874323 hasConceptScore W2940874323C71924100 @default.
- W2940874323 hasConceptScore W2940874323C86803240 @default.
- W2940874323 hasIssue "2" @default.
- W2940874323 hasOpenAccess W2940874323 @default.
- W2940874323 hasRelatedWork W1496514863 @default.
- W2940874323 hasRelatedWork W1964044841 @default.
- W2940874323 hasRelatedWork W1989690769 @default.
- W2940874323 hasRelatedWork W1993302448 @default.
- W2940874323 hasRelatedWork W2006979416 @default.
- W2940874323 hasRelatedWork W2107460197 @default.
- W2940874323 hasRelatedWork W2139559023 @default.
- W2940874323 hasRelatedWork W2319272111 @default.
- W2940874323 hasRelatedWork W2519332423 @default.
- W2940874323 hasRelatedWork W2581492380 @default.
- W2940874323 hasRelatedWork W2742922559 @default.
- W2940874323 hasRelatedWork W2751797039 @default.
- W2940874323 hasRelatedWork W2764008174 @default.
- W2940874323 hasRelatedWork W2897507615 @default.
- W2940874323 hasRelatedWork W2904412731 @default.
- W2940874323 hasRelatedWork W2913194863 @default.
- W2940874323 hasRelatedWork W3010797569 @default.
- W2940874323 hasRelatedWork W1760037814 @default.
- W2940874323 hasRelatedWork W2950637898 @default.
- W2940874323 hasRelatedWork W3012315803 @default.
- W2940874323 hasVolume "1" @default.
- W2940874323 isParatext "false" @default.
- W2940874323 isRetracted "false" @default.
- W2940874323 magId "2940874323" @default.
- W2940874323 workType "article" @default.