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- W2940883995 abstract "CXCR5 mediates homing of both B and follicular helper T (TFH) cells into follicles of secondary lymphoid organs. We found that CXCR5+CD8+ T cells are present in human tonsils and follicular lymphoma, inhibit TFH-mediated B cell differentiation, and exhibit strong cytotoxic activity. Consistent with these findings, adoptive transfer of CXCR5+CD8+ T cells into an animal model of lymphoma resulted in significantly greater antitumor activity than CXCR5-CD8+ T cells. Furthermore, RNA-Seq-based transcriptional profiling revealed 77 differentially expressed genes unique to CXCR5+CD8+ T cells. Among these, a signature comprised of 33 upregulated genes correlated with improved survival in follicular lymphoma patients. We also showed that CXCR5+CD8+ T cells could be induced and expanded ex vivo using IL-23 plus TGF-β, suggesting a possible strategy to generate these cells for clinical application. In summary, our study identified CXCR5+CD8+ T cells as a distinct T cell subset with ability to suppress TFH-mediated B cell differentiation, exert strong antitumor activity, and confer favorable prognosis in follicular lymphoma patients." @default.
- W2940883995 created "2019-05-03" @default.
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- W2940883995 date "2019-04-25" @default.
- W2940883995 modified "2023-10-15" @default.
- W2940883995 title "CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity" @default.
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- W2940883995 doi "https://doi.org/10.1038/s41375-019-0464-2" @default.
- W2940883995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6814517" @default.
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- W2940883995 hasPublicationYear "2019" @default.
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