Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940892893> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2940892893 abstract "Cytomegalovirus (CMV) establishes life-long infection of its host, ensuring continuous supply of effector memory CD8+ T cells. CMVs possess numerous immunoevasion genes able to modulate basically any part of immune response, including NK cell and CD8+ T cell response. It is well established that deletion of these viral inhibitors leads to virus attenuation in vivo.These features make CMV a very attractive CD8+ T cell vaccine vector candidate. Control of CMV infection is in great part dependent on NKG2D, an activating receptor when expressed on NK cells and co- stimulatory one when expressed on CD8+ T cells. We have constructed highly attenuated mouse CMV (MCMV) expressing NKG2D ligand RAE- 1γ inserted in place of its viral inhibitor (Slavuljica et al, 2010) and foreign CD8+ T cell epitope as well (Trsan et al, 2013). Such a recombinant vaccine- vector provided outstanding and long-lasting CD8+ T cell-mediated protection against challenge infections. Moreover, RAE-1γMCMV-vector circumvented MCMV interference of antigen presentation, improved antigen presentation to CD8+ T cells and potentiated memory CD8+ T cell response. Surprisingly, these immuno enhancing properties of RAE-1γ expressing MCMV vector were retained even in NKG2D deficient mice, pointing to additional NKG2D-independent immune function of RAE-1γ. In my talk, I will discuss the capacity of MCMV expressing RAE-1γ as a vaccine vector against other pathogens, as well as tumors." @default.
- W2940892893 created "2019-05-03" @default.
- W2940892893 creator A5038051461 @default.
- W2940892893 date "2015-01-01" @default.
- W2940892893 modified "2023-09-26" @default.
- W2940892893 title "VACCINES AND INNATE IMMUNITY: LESSONS FROM CYTOMEGALOVIRUS IMMUNOEVASION" @default.
- W2940892893 hasPublicationYear "2015" @default.
- W2940892893 type Work @default.
- W2940892893 sameAs 2940892893 @default.
- W2940892893 citedByCount "0" @default.
- W2940892893 crossrefType "journal-article" @default.
- W2940892893 hasAuthorship W2940892893A5038051461 @default.
- W2940892893 hasConcept C147483822 @default.
- W2940892893 hasConcept C154317977 @default.
- W2940892893 hasConcept C159047783 @default.
- W2940892893 hasConcept C167672396 @default.
- W2940892893 hasConcept C202751555 @default.
- W2940892893 hasConcept C203014093 @default.
- W2940892893 hasConcept C2776090121 @default.
- W2940892893 hasConcept C2778867473 @default.
- W2940892893 hasConcept C55493867 @default.
- W2940892893 hasConcept C86803240 @default.
- W2940892893 hasConcept C8891405 @default.
- W2940892893 hasConceptScore W2940892893C147483822 @default.
- W2940892893 hasConceptScore W2940892893C154317977 @default.
- W2940892893 hasConceptScore W2940892893C159047783 @default.
- W2940892893 hasConceptScore W2940892893C167672396 @default.
- W2940892893 hasConceptScore W2940892893C202751555 @default.
- W2940892893 hasConceptScore W2940892893C203014093 @default.
- W2940892893 hasConceptScore W2940892893C2776090121 @default.
- W2940892893 hasConceptScore W2940892893C2778867473 @default.
- W2940892893 hasConceptScore W2940892893C55493867 @default.
- W2940892893 hasConceptScore W2940892893C86803240 @default.
- W2940892893 hasConceptScore W2940892893C8891405 @default.
- W2940892893 hasLocation W29408928931 @default.
- W2940892893 hasOpenAccess W2940892893 @default.
- W2940892893 hasPrimaryLocation W29408928931 @default.
- W2940892893 hasRelatedWork W1540524475 @default.
- W2940892893 hasRelatedWork W1953035570 @default.
- W2940892893 hasRelatedWork W1980997434 @default.
- W2940892893 hasRelatedWork W1984872855 @default.
- W2940892893 hasRelatedWork W1991722867 @default.
- W2940892893 hasRelatedWork W1992576863 @default.
- W2940892893 hasRelatedWork W2036290659 @default.
- W2940892893 hasRelatedWork W2084899911 @default.
- W2940892893 hasRelatedWork W2086880485 @default.
- W2940892893 hasRelatedWork W2097266071 @default.
- W2940892893 hasRelatedWork W2137522671 @default.
- W2940892893 hasRelatedWork W2141521797 @default.
- W2940892893 hasRelatedWork W2149056352 @default.
- W2940892893 hasRelatedWork W2172188624 @default.
- W2940892893 hasRelatedWork W2540004522 @default.
- W2940892893 hasRelatedWork W2736206370 @default.
- W2940892893 hasRelatedWork W2736670278 @default.
- W2940892893 hasRelatedWork W2937607355 @default.
- W2940892893 hasRelatedWork W2980814548 @default.
- W2940892893 hasRelatedWork W3175975623 @default.
- W2940892893 isParatext "false" @default.
- W2940892893 isRetracted "false" @default.
- W2940892893 magId "2940892893" @default.
- W2940892893 workType "article" @default.