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- W2940902085 abstract "Herein, an injectable formulation composed of a low molecular weight gelator (LMWG) based hydrogel and drug-loaded polymeric nanocapsules (NCs) is described. The NCs, made of hyaluronic acid and polyglutamic acid and loaded with C14-Gemcitabine (GEM C14), showed a size of 40 and 80 nm and a encapsulation efficiency >90%. These NCs exhibited a capacity to control the release of the encapsulated drug for >1 month. GEM C14-loaded NCs showed activity against various cancer cell lines in vitro; cell growth inhibition by 50% (GI50) values of 15 ± 6, 10 ± 9, 13 ± 3 and 410 ± 463 nM were obtained in HCT 116, MIA PaCa-2, Panc-1 and Panc-1 GEM resistant cell lines respectively. Nanocomposite hydrogels were prepared using the LMWG - N4-octanoyl-2'-deoxycytidine and loaded for the first time with polymeric NCs. 2% and 4% w/v nanocapsule concentrations as compared to 8% w/v NC concentrations with 2% and 3% w/v gelator concentrations gave mechanically stronger gels as determined by oscillatory rheology. Most importantly, the nanocomposite formulation reformed instantly into a gel after injection through a needle. Based on these properties, the nanocomposite gel formulation has potential for the intratumoural delivery of anticancer drugs." @default.
- W2940902085 created "2019-05-03" @default.
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- W2940902085 date "2019-06-01" @default.
- W2940902085 modified "2023-09-26" @default.
- W2940902085 title "A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs" @default.
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- W2940902085 doi "https://doi.org/10.1016/j.ijpharm.2019.04.070" @default.
- W2940902085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31029659" @default.
- W2940902085 hasPublicationYear "2019" @default.
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