FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940914582> ?p ?o ?g. }

• W2940914582 endingPage "19383" @default.
• W2940914582 startingPage "19366" @default.
• W2940914582 abstract "Abstract Epigenetic modifications are heritable variations in gene expression not encoded by the DNA sequence. According to reports, a large number of studies have been performed to characterize epigenetic modification during normal development and also in cancer. Epigenetics can be regarded more widely to contain all of the changes in expression of genes that make by adjusted interactions between the regulatory portions of DNA or messenger RNAs that lead to indirect variation in the DNA sequence. In the last decade, epigenetic modification importance in colorectal cancer (CRC) pathogenesis was demonstrated powerfully. Although developments in CRC therapy have been made in the last years, much work is required as it remains the second leading cause of cancer death. Nowadays, epigenetic programs and genetic change have pivotal roles in the CRC incidence as well as progression. While our knowledge about epigenetic mechanism in CRC is not comprehensive, selective histone modifications and resultant chromatin conformation together with DNA methylation most likely regulate CRC pathogenesis that involved genes expression. Undoubtedly, the advanced understanding of epigenetic‐based gene expression regulation in the CRC is essential to make epigenetic drugs for CRC therapy. The major aim of this review is to deliver a summary of valuable results that represent evidence of principle for epigenetic‐based therapeutic approaches employment in CRC with a focus on the advantages of epigenetic‐based therapy in the inhibition of the CRC metastasis and proliferation." @default.
• W2940914582 created "2019-05-03" @default.
• W2940914582 creator A5039042437 @default.
• W2940914582 creator A5054645087 @default.
• W2940914582 creator A5063899354 @default.
• W2940914582 creator A5076469609 @default.
• W2940914582 date "2019-04-24" @default.
• W2940914582 modified "2023-10-17" @default.
• W2940914582 title "Epigenetic‐based therapy for colorectal cancer: Prospect and involved mechanisms" @default.
• W2940914582 cites W1158153894 @default.
• W2940914582 cites W1515045756 @default.
• W2940914582 cites W1847375317 @default.
• W2940914582 cites W1892952192 @default.
• W2940914582 cites W1895649416 @default.
• W2940914582 cites W1912743197 @default.
• W2940914582 cites W1917608452 @default.
• W2940914582 cites W1919287182 @default.
• W2940914582 cites W1967180140 @default.
• W2940914582 cites W1968088645 @default.
• W2940914582 cites W1969858573 @default.
• W2940914582 cites W1974254202 @default.
• W2940914582 cites W1975616657 @default.
• W2940914582 cites W1978162793 @default.
• W2940914582 cites W1979587260 @default.
• W2940914582 cites W198515344 @default.
• W2940914582 cites W1989841681 @default.
• W2940914582 cites W1990044572 @default.
• W2940914582 cites W1994852323 @default.
• W2940914582 cites W2008775304 @default.
• W2940914582 cites W2009824580 @default.
• W2940914582 cites W2018571397 @default.
• W2940914582 cites W2019049058 @default.
• W2940914582 cites W2023397076 @default.
• W2940914582 cites W2027641687 @default.
• W2940914582 cites W2028044172 @default.
• W2940914582 cites W2031647162 @default.
• W2940914582 cites W2034913624 @default.
• W2940914582 cites W2038159709 @default.
• W2940914582 cites W2039165130 @default.
• W2940914582 cites W2042883526 @default.
• W2940914582 cites W2043363016 @default.
• W2940914582 cites W2046458419 @default.
• W2940914582 cites W2046983501 @default.
• W2940914582 cites W2055489631 @default.
• W2940914582 cites W2059201392 @default.
• W2940914582 cites W2062190843 @default.
• W2940914582 cites W2065434214 @default.
• W2940914582 cites W2066633590 @default.
• W2940914582 cites W2075293884 @default.
• W2940914582 cites W2077342495 @default.
• W2940914582 cites W2077810230 @default.
• W2940914582 cites W2078060536 @default.
• W2940914582 cites W2078521443 @default.
• W2940914582 cites W2084406998 @default.
• W2940914582 cites W2084908485 @default.
• W2940914582 cites W2085048499 @default.
• W2940914582 cites W2085653208 @default.
• W2940914582 cites W2087548057 @default.
• W2940914582 cites W2091747532 @default.
• W2940914582 cites W2093022647 @default.
• W2940914582 cites W2096330673 @default.
• W2940914582 cites W2099343472 @default.
• W2940914582 cites W2110395619 @default.
• W2940914582 cites W2111349724 @default.
• W2940914582 cites W2113983227 @default.
• W2940914582 cites W2115316179 @default.
• W2940914582 cites W2115761146 @default.
• W2940914582 cites W2118133069 @default.
• W2940914582 cites W2119674246 @default.
• W2940914582 cites W2127180680 @default.
• W2940914582 cites W2127540087 @default.
• W2940914582 cites W2130407757 @default.
• W2940914582 cites W2131760952 @default.
• W2940914582 cites W2137656127 @default.
• W2940914582 cites W2139528114 @default.
• W2940914582 cites W2147524392 @default.
• W2940914582 cites W2159888068 @default.
• W2940914582 cites W2161506057 @default.
• W2940914582 cites W2164534360 @default.
• W2940914582 cites W2165638033 @default.
• W2940914582 cites W2166616648 @default.
• W2940914582 cites W2166982925 @default.
• W2940914582 cites W2168132354 @default.
• W2940914582 cites W2169435493 @default.
• W2940914582 cites W2181788738 @default.
• W2940914582 cites W2182886286 @default.
• W2940914582 cites W2256283977 @default.
• W2940914582 cites W2262414037 @default.
• W2940914582 cites W2269808816 @default.
• W2940914582 cites W2275636235 @default.
• W2940914582 cites W2284098333 @default.
• W2940914582 cites W2289683295 @default.
• W2940914582 cites W2304728978 @default.
• W2940914582 cites W2346835588 @default.
• W2940914582 cites W2419179749 @default.
• W2940914582 cites W2419243575 @default.
• W2940914582 cites W2441236537 @default.
• W2940914582 cites W2513030442 @default.

• next