Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940925693> ?p ?o ?g. }
- W2940925693 abstract "ABSTRACT Salmonella enterica Javiana is a leading cause of severe foodborne Salmonellosis. Despite its emergence as a major foodborne pathogen, little is known of how S. Javiana interacts with intestinal epithelial cells, or of potential methods for ameliorating the bacterial-host interaction. Using cell-based adhesion, invasion and lactate dehydrogenase release assays, we observed an invasive and cytotoxic effect of S. Javiana on intestinal epithelial cells. We assessed the effect of probiotic species of lactic acid bacteria (LAB) on the S. Javiana-host cell interaction, and hypothesized that LAB would reduce S. Javiana infectivity. Salmonella enterica Javiana invasion was significantly impaired in host cells pre-treated with live Lactobacillus acidophilus and Lactobacillus rhamnosus. In addition, pre-exposure of host cells to live L. acidophilus, L. rhamnosus and L. casei reduced S. Javiana-induced cytotoxicity, while heat-killed LAB cultures had no effect on S. Javiana invasion or cytotoxicity. qRT-PCR analysis revealed that S. Javiana exposed to L. acidophilus and L. rhamnosus exhibited reduced virulence gene expression. Moreover, pre-treating host cells with LAB prior to S. Javiana infection reduced host cell production of inflammatory cytokines. Data suggest a potential protective effect of L. acidophilus, L. rhamnosus and L. casei against intestinal epithelial infection and pathogen-induced damage caused by S. Javiana." @default.
- W2940925693 created "2019-05-03" @default.
- W2940925693 creator A5001132788 @default.
- W2940925693 creator A5043076117 @default.
- W2940925693 creator A5070489349 @default.
- W2940925693 creator A5080290347 @default.
- W2940925693 date "2019-04-01" @default.
- W2940925693 modified "2023-09-25" @default.
- W2940925693 title "Lactic acid bacteria decrease <i>Salmonella enterica</i> Javiana virulence and modulate host inflammation during infection of an intestinal epithelial cell line" @default.
- W2940925693 cites W1515723214 @default.
- W2940925693 cites W1563923105 @default.
- W2940925693 cites W1735900413 @default.
- W2940925693 cites W1846083506 @default.
- W2940925693 cites W1853957296 @default.
- W2940925693 cites W1856169132 @default.
- W2940925693 cites W1902352414 @default.
- W2940925693 cites W1929532073 @default.
- W2940925693 cites W1937264215 @default.
- W2940925693 cites W1940453590 @default.
- W2940925693 cites W1966223820 @default.
- W2940925693 cites W1972441174 @default.
- W2940925693 cites W1974738011 @default.
- W2940925693 cites W1975167841 @default.
- W2940925693 cites W1988105771 @default.
- W2940925693 cites W2002513687 @default.
- W2940925693 cites W2004607066 @default.
- W2940925693 cites W2005334980 @default.
- W2940925693 cites W2007075553 @default.
- W2940925693 cites W2021234391 @default.
- W2940925693 cites W2024672414 @default.
- W2940925693 cites W2029929322 @default.
- W2940925693 cites W2043623479 @default.
- W2940925693 cites W2047067167 @default.
- W2940925693 cites W2069143337 @default.
- W2940925693 cites W2071246675 @default.
- W2940925693 cites W2079968415 @default.
- W2940925693 cites W2079990135 @default.
- W2940925693 cites W2081226705 @default.
- W2940925693 cites W2083733429 @default.
- W2940925693 cites W2091369121 @default.
- W2940925693 cites W2093774099 @default.
- W2940925693 cites W2097959543 @default.
- W2940925693 cites W2100034360 @default.
- W2940925693 cites W2101997581 @default.
- W2940925693 cites W2103403925 @default.
- W2940925693 cites W2106604753 @default.
- W2940925693 cites W2107277218 @default.
- W2940925693 cites W2111298931 @default.
- W2940925693 cites W2112364955 @default.
- W2940925693 cites W2121222441 @default.
- W2940925693 cites W2122800995 @default.
- W2940925693 cites W2137749186 @default.
- W2940925693 cites W2138611522 @default.
- W2940925693 cites W2145669364 @default.
- W2940925693 cites W2149517064 @default.
- W2940925693 cites W2158859130 @default.
- W2940925693 cites W2159450781 @default.
- W2940925693 cites W2160113463 @default.
- W2940925693 cites W2164633657 @default.
- W2940925693 cites W2168416849 @default.
- W2940925693 cites W2171131023 @default.
- W2940925693 cites W2172284440 @default.
- W2940925693 cites W2184405267 @default.
- W2940925693 cites W2218703360 @default.
- W2940925693 cites W2252348097 @default.
- W2940925693 cites W2326433963 @default.
- W2940925693 cites W2403365761 @default.
- W2940925693 cites W2411365636 @default.
- W2940925693 cites W2501693264 @default.
- W2940925693 cites W2511364350 @default.
- W2940925693 cites W2559975136 @default.
- W2940925693 cites W2566004376 @default.
- W2940925693 cites W2581345147 @default.
- W2940925693 cites W2594794139 @default.
- W2940925693 cites W2737672146 @default.
- W2940925693 cites W2748368384 @default.
- W2940925693 cites W2767270188 @default.
- W2940925693 cites W2791272024 @default.
- W2940925693 cites W2803487426 @default.
- W2940925693 cites W2807906786 @default.
- W2940925693 cites W2883874525 @default.
- W2940925693 cites W2888440846 @default.
- W2940925693 cites W2892926776 @default.
- W2940925693 cites W2896421548 @default.
- W2940925693 cites W2898711555 @default.
- W2940925693 cites W2900048861 @default.
- W2940925693 cites W2902646532 @default.
- W2940925693 cites W2903658638 @default.
- W2940925693 cites W2919536928 @default.
- W2940925693 cites W4255909721 @default.
- W2940925693 cites W5581280 @default.
- W2940925693 doi "https://doi.org/10.1093/femspd/ftz025" @default.
- W2940925693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6504658" @default.
- W2940925693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31065694" @default.
- W2940925693 hasPublicationYear "2019" @default.
- W2940925693 type Work @default.
- W2940925693 sameAs 2940925693 @default.
- W2940925693 citedByCount "14" @default.
- W2940925693 countsByYear W29409256932020 @default.
- W2940925693 countsByYear W29409256932021 @default.