FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940964174> ?p ?o ?g. }

• W2940964174 endingPage "574" @default.
• W2940964174 startingPage "574" @default.
• W2940964174 abstract "Patient-derived xenografts (PDXs) are powerful tools for translational cancer research. Here, we established PDX models from different molecular subtypes of breast cancer for in vivo drug tests and compared the histopathologic features of PDX model tumors with those of patient tumors. Predictive biomarkers were identified by gene expression analysis of PDX samples using Nanostring nCount cancer panels. Validation of predictive biomarkers for treatment response was conducted in established PDX models by in vivo drug testing. Twenty breast cancer PDX models were generated from different molecular subtypes (overall success rate, 17.5%; 3.6% for HR+/HER2−, 21.4% for HR+/HER2+, 21.9% for HR−/HER2+ and 22.5% for triple-negative breast cancer (TNBC)). The histopathologic features of original tumors were retained in the PDX models. We detected upregulated HIF1A, RAF1, AKT2 and VEGFA in TNBC cases and demonstrated the efficacy of combined treatment with sorafenib and everolimus or docetaxel and bevacizumab in each TNBC model. Additionally, we identified upregulated HIF1A in two cases of trastuzumab-exposed HR−/HER2+ PDX models and validated the efficacy of the HIF1A inhibitor, PX-478, alone or in combination with neratinib. Our results demonstrate that PDX models can be used as effective tools for predicting therapeutic markers and evaluating personalized treatment strategies in breast cancer patients with resistance to standard chemotherapy regimens." @default.
• W2940964174 created "2019-05-03" @default.
• W2940964174 creator A5005727794 @default.
• W2940964174 creator A5011524762 @default.
• W2940964174 creator A5032088387 @default.
• W2940964174 creator A5037295746 @default.
• W2940964174 creator A5038366277 @default.
• W2940964174 creator A5038481896 @default.
• W2940964174 creator A5076890048 @default.
• W2940964174 creator A5084695505 @default.
• W2940964174 creator A5085471950 @default.
• W2940964174 date "2019-04-23" @default.
• W2940964174 modified "2023-10-16" @default.
• W2940964174 title "Integrative In Vivo Drug Testing Using Gene Expression Signature and Patient-Derived Xenografts from Treatment-Refractory HER2 Positive and Triple-Negative Subtypes of Breast Cancer" @default.
• W2940964174 cites W1854370623 @default.
• W2940964174 cites W1857831683 @default.
• W2940964174 cites W1970682511 @default.
• W2940964174 cites W1997533142 @default.
• W2940964174 cites W2005706175 @default.
• W2940964174 cites W2009164582 @default.
• W2940964174 cites W2009268313 @default.
• W2940964174 cites W2017181626 @default.
• W2940964174 cites W2027497744 @default.
• W2940964174 cites W2034428193 @default.
• W2940964174 cites W2037799666 @default.
• W2940964174 cites W2043398720 @default.
• W2940964174 cites W2053221827 @default.
• W2940964174 cites W2055242813 @default.
• W2940964174 cites W2070403181 @default.
• W2940964174 cites W2101979288 @default.
• W2940964174 cites W2103875073 @default.
• W2940964174 cites W2104666893 @default.
• W2940964174 cites W2109937560 @default.
• W2940964174 cites W2113506041 @default.
• W2940964174 cites W2124358769 @default.
• W2940964174 cites W2126275851 @default.
• W2940964174 cites W2127096730 @default.
• W2940964174 cites W2135797694 @default.
• W2940964174 cites W2137853125 @default.
• W2940964174 cites W2140765540 @default.
• W2940964174 cites W2162647235 @default.
• W2940964174 cites W2167520439 @default.
• W2940964174 cites W2168086498 @default.
• W2940964174 cites W2168561598 @default.
• W2940964174 cites W2281691828 @default.
• W2940964174 cites W2524451426 @default.
• W2940964174 cites W2550859983 @default.
• W2940964174 cites W2560863391 @default.
• W2940964174 cites W2608685060 @default.
• W2940964174 cites W2754871120 @default.
• W2940964174 cites W2774944351 @default.
• W2940964174 cites W2797988325 @default.
• W2940964174 cites W2799444748 @default.
• W2940964174 cites W2905822642 @default.
• W2940964174 cites W3117975060 @default.
• W2940964174 cites W4293162689 @default.
• W2940964174 cites W4294214970 @default.
• W2940964174 cites W628038580 @default.
• W2940964174 doi "https://doi.org/10.3390/cancers11040574" @default.
• W2940964174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6520730" @default.
• W2940964174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31018595" @default.
• W2940964174 hasPublicationYear "2019" @default.
• W2940964174 type Work @default.
• W2940964174 sameAs 2940964174 @default.
• W2940964174 citedByCount "8" @default.
• W2940964174 countsByYear W29409641742019 @default.
• W2940964174 countsByYear W29409641742021 @default.
• W2940964174 countsByYear W29409641742022 @default.
• W2940964174 countsByYear W29409641742023 @default.
• W2940964174 crossrefType "journal-article" @default.
• W2940964174 hasAuthorship W2940964174A5005727794 @default.
• W2940964174 hasAuthorship W2940964174A5011524762 @default.
• W2940964174 hasAuthorship W2940964174A5032088387 @default.
• W2940964174 hasAuthorship W2940964174A5037295746 @default.
• W2940964174 hasAuthorship W2940964174A5038366277 @default.
• W2940964174 hasAuthorship W2940964174A5038481896 @default.
• W2940964174 hasAuthorship W2940964174A5076890048 @default.
• W2940964174 hasAuthorship W2940964174A5084695505 @default.
• W2940964174 hasAuthorship W2940964174A5085471950 @default.
• W2940964174 hasBestOaLocation W29409641741 @default.
• W2940964174 hasConcept C121608353 @default.
• W2940964174 hasConcept C126322002 @default.
• W2940964174 hasConcept C143998085 @default.
• W2940964174 hasConcept C150903083 @default.
• W2940964174 hasConcept C207001950 @default.
• W2940964174 hasConcept C2776694085 @default.
• W2940964174 hasConcept C2777292972 @default.
• W2940964174 hasConcept C2777329042 @default.
• W2940964174 hasConcept C2777802072 @default.
• W2940964174 hasConcept C2779699572 @default.
• W2940964174 hasConcept C2779786085 @default.
• W2940964174 hasConcept C2780110267 @default.
• W2940964174 hasConcept C2780394083 @default.
• W2940964174 hasConcept C2781190966 @default.
• W2940964174 hasConcept C31194975 @default.
• W2940964174 hasConcept C502942594 @default.
• W2940964174 hasConcept C530470458 @default.
• W2940964174 hasConcept C71924100 @default.

• next