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- W2940989432 abstract "Background: Cervical cancer is a preventable disease caused by human papillomaviruses. It is the third mostcommon cancer to occur in women of reproductive age. The ADAM9 protein plays a role in basement membranedegradation and tumour metastasis in certain types of tumour. Thus, it has the potential to become a new targetedtherapy. The objective of this study was to investigate ADAM9 expression in cervical cancer and to determine thefactors associated with ADAM9-positive expression. Methods: This cross-sectional study was conducted in HospitalUniversiti Sains Malaysia (HUSM) Kelantan, Malaysia from December 2010 to December 2012. Histological slidesobtained from 95 cervical cancer cases diagnosed and/or treated in HUSM from 2000 to 2010 were analysed. TheADAM9 immunostain was then performed on the paraffin blocks. The statistical data entry and analysis were doneusing SPSS version 18.0. Multiple logistic regression analysis was performed to determine the factors associated withADAM9-positive expression. Result: Of the 95 cervical cancer patients included in the study, 72 (75.8%) patients showedpositive ADAM9 expression. The mean age of the patients was 53.89 (10.83) years old. Squamous cell carcinoma wasthe most common type of cervical cancer (n = 67, 70.5%). Factors that showed a statistically significant associationwith ADAM9-positive expression were tumour size (adjusted odds ratio [adj. OR]: 1.08; 95% confidence interval[CI]: 1.02, 1.13; p = 0.004), distant metastasis (adj. OR: 12.82; 95% CI: 1.91, 86.13; p = 0.009) and the histologicaltype of cervical cancer (i.e. squamous cell carcinoma) (adj. OR: 7.39; 95% CI: 1.42, 38.51; p = 0.017). Conclusion:The ADAM9 immunostain was consistently positive in malignant cells. Thus, ADAM9 expression can be used as aprognostic/therapeutic indicator in aiding clinician decision-making regarding patient treatment (targeted therapy)." @default.
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- W2940989432 date "2019-04-01" @default.
- W2940989432 modified "2023-10-18" @default.
- W2940989432 title "ADAM9 Expression in Uterine Cervical Cancer and Its Associated Factors" @default.
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- W2940989432 doi "https://doi.org/10.31557/apjcp.2019.20.4.1081" @default.
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