FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2940997658> ?p ?o ?g. }

• W2940997658 endingPage "e116" @default.
• W2940997658 startingPage "e109" @default.
• W2940997658 abstract "Background Venous thromboembolism (VTE) is an important complication for treatment of acute lymphoblastic leukemia (ALL) in children. Especially, ALL treatment, with therapeutics such as asparaginase and steroids, increases the thrombotic risk by reduction in procoagulant and anticoagulant proteins. Replacement of deficient natural anticoagulants by administration of fresh frozen plasma (FFP) may have a preventive effect on the occurrence of VTE. Methods We retrospectively analyzed all consecutive children (≤18 years) with ALL, treated on the Dutch Childhood Oncology Group (DCOG) ALL-9 and ALL-10 protocols at the Emma Children's Hospital Academic Medical Center between February 1997 and January 2012, to study the effect of FFP on VTE incidence, antithrombin and fibrinogen plasma levels, and VTE risk factors. Results In total, 18/205 patients developed VTE (8.8%; 95% confidence interval [CI]: 4.9-12.7%). In all patients, VTE occurred after asparaginase administration. In total, 82/205 patients (40%) received FFP. FFP supplementation did not prevent VTE or alter plasma levels of antithrombin or fibrinogen. In the multivariate analysis, VTE occurred significantly more frequently in children ≥12 years (odds ratio [OR]: 3.89; 95% CI: 1.29-11.73) and treated according to the ALL-10 protocol (OR: 3.71; 95% CI: 1.13-12.17). Conclusion FFP supplementation does not seem to be beneficial in the prevention of VTE in pediatric ALL patients. In addition, age ≥12 years and treatment according to the DCOG ALL-10 protocol with intensive and prolonged administration of asparaginase in combination with prednisone are risk factors. There is a need for effective preventive strategies in ALL patients at high risk for VTE." @default.
• W2940997658 created "2019-05-03" @default.
• W2940997658 creator A5001866863 @default.
• W2940997658 creator A5015459043 @default.
• W2940997658 creator A5044877139 @default.
• W2940997658 creator A5070581594 @default.
• W2940997658 creator A5072534575 @default.
• W2940997658 creator A5084943918 @default.
• W2940997658 creator A5089209239 @default.
• W2940997658 date "2019-04-01" @default.
• W2940997658 modified "2023-10-18" @default.
• W2940997658 title "Venous Thrombosis in Children with Acute Lymphoblastic Leukemia Treated on DCOG ALL-9 and ALL-10 Protocols: The Effect of Fresh Frozen Plasma" @default.
• W2940997658 cites W104552217 @default.
• W2940997658 cites W106711548 @default.
• W2940997658 cites W1504555330 @default.
• W2940997658 cites W1898315192 @default.
• W2940997658 cites W1971203417 @default.
• W2940997658 cites W1980846800 @default.
• W2940997658 cites W1985556604 @default.
• W2940997658 cites W1991241424 @default.
• W2940997658 cites W1999820147 @default.
• W2940997658 cites W1999920194 @default.
• W2940997658 cites W2011532906 @default.
• W2940997658 cites W2020328491 @default.
• W2940997658 cites W2020419693 @default.
• W2940997658 cites W2026838518 @default.
• W2940997658 cites W2034485178 @default.
• W2940997658 cites W2048708519 @default.
• W2940997658 cites W2055987519 @default.
• W2940997658 cites W2056263738 @default.
• W2940997658 cites W2058534416 @default.
• W2940997658 cites W2068256699 @default.
• W2940997658 cites W2068646871 @default.
• W2940997658 cites W2074105102 @default.
• W2940997658 cites W2074161987 @default.
• W2940997658 cites W2089471154 @default.
• W2940997658 cites W2091504035 @default.
• W2940997658 cites W2097682287 @default.
• W2940997658 cites W2107419838 @default.
• W2940997658 cites W2117345900 @default.
• W2940997658 cites W2127153931 @default.
• W2940997658 cites W2131184407 @default.
• W2940997658 cites W2134118606 @default.
• W2940997658 cites W2153818728 @default.
• W2940997658 cites W2162051878 @default.
• W2940997658 cites W2189457108 @default.
• W2940997658 cites W2228862479 @default.
• W2940997658 cites W2413038045 @default.
• W2940997658 cites W2476139630 @default.
• W2940997658 cites W2545458768 @default.
• W2940997658 cites W2728114987 @default.
• W2940997658 cites W2754782458 @default.
• W2940997658 cites W2765646098 @default.
• W2940997658 cites W2792190033 @default.
• W2940997658 cites W2892578575 @default.
• W2940997658 cites W2918122826 @default.
• W2940997658 doi "https://doi.org/10.1055/s-0039-1688412" @default.
• W2940997658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6524923" @default.
• W2940997658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31249990" @default.
• W2940997658 hasPublicationYear "2019" @default.
• W2940997658 type Work @default.
• W2940997658 sameAs 2940997658 @default.
• W2940997658 citedByCount "3" @default.
• W2940997658 countsByYear W29409976582023 @default.
• W2940997658 crossrefType "journal-article" @default.
• W2940997658 hasAuthorship W2940997658A5001866863 @default.
• W2940997658 hasAuthorship W2940997658A5015459043 @default.
• W2940997658 hasAuthorship W2940997658A5044877139 @default.
• W2940997658 hasAuthorship W2940997658A5070581594 @default.
• W2940997658 hasAuthorship W2940997658A5072534575 @default.
• W2940997658 hasAuthorship W2940997658A5084943918 @default.
• W2940997658 hasAuthorship W2940997658A5089209239 @default.
• W2940997658 hasBestOaLocation W29409976581 @default.
• W2940997658 hasConcept C120665830 @default.
• W2940997658 hasConcept C121332964 @default.
• W2940997658 hasConcept C126322002 @default.
• W2940997658 hasConcept C141071460 @default.
• W2940997658 hasConcept C156957248 @default.
• W2940997658 hasConcept C187212893 @default.
• W2940997658 hasConcept C2776265017 @default.
• W2940997658 hasConcept C2777557582 @default.
• W2940997658 hasConcept C2778461978 @default.
• W2940997658 hasConcept C2778904437 @default.
• W2940997658 hasConcept C2779026020 @default.
• W2940997658 hasConcept C2780868729 @default.
• W2940997658 hasConcept C2909962599 @default.
• W2940997658 hasConcept C61511704 @default.
• W2940997658 hasConcept C66112548 @default.
• W2940997658 hasConcept C71924100 @default.
• W2940997658 hasConcept C89560881 @default.
• W2940997658 hasConceptScore W2940997658C120665830 @default.
• W2940997658 hasConceptScore W2940997658C121332964 @default.
• W2940997658 hasConceptScore W2940997658C126322002 @default.
• W2940997658 hasConceptScore W2940997658C141071460 @default.
• W2940997658 hasConceptScore W2940997658C156957248 @default.
• W2940997658 hasConceptScore W2940997658C187212893 @default.
• W2940997658 hasConceptScore W2940997658C2776265017 @default.
• W2940997658 hasConceptScore W2940997658C2777557582 @default.

• next